Wiley
Journal of Magnetic Resonance Imaging
,  том 62 ,  издание 3 ,  страницы 800-811

Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom

Jitka Starekova 1
, 
David R Rutkowski 2
, 
W K Bae 3
, 
Hung Phi Do 4
, 
Ananth J. Madhuranthakam 5
, 
Vadim Malis 3
, 
Shengqing Lin 5
, 
Suraj Serai 6
, 
Takeshi Yokoo 5
, 
Scott B. Reeder 1, 7, 8, 9, 10
, 
Jean H Brittain 2
, 
Diego Hernando 1, 8
1
 
2
 
Calimetrix Madison Wisconsin USA | 
3
 
4
 
Canon Medical Systems Tustin California USA | 
5
 
6
 
7
 
8
 
9
 
10
 
Тип публикации: Journal Article
Дата публикации: 2025-04-18
Wiley
scimago Q1
wos Q1
БС1
SJR: 1.248
CiteScore: 8.7
Impact factor: 3.5
ISSN: 10531807, 15222586
Краткое описание
ABSTRACT
Background

Fat and iron deposition confound measurements of R2* and proton density fat fraction (PDFF), respectively, yet their combined impact on reproducibility is poorly understood.

Purpose

To evaluate the multi‐center, multi‐vendor reproducibility of PDFF and R2* quantification using a PDFF‐R2* phantom.

Study Type

Prospective multi‐center, phantom study.

Phantom

Commercial PDFF‐R2* phantom with simultaneously controlled combination of PDFF (0%–30%) and R2* (50–600 s−1) values.

Field Strength/Sequence

1.5‐T and 3‐T, three‐dimensional (3D) multi‐echo, spoiled‐gradient‐echo sequences, in four different centers, each with a different vendor.

Assessment

Two acquisition protocols were used, optimized for moderate R2* (Protocol 1) and high R2* (Protocol 2), respectively. The phantom was imaged multiple times at one of the centers to assess its stability.

Statistical Tests

Intraclass correlation coefficient (ICC), linear regression analysis, reproducibility coefficient (RDC) and repeatability coefficient (RC).

Results

Excellent agreement was observed for PDFF measurements between centers, vendors, field strengths, and protocols (ICC = 0.97). Stratified by protocol, excellent agreement was observed, with ICC = 0.96 (RDC = 6.2%) for Protocol 1 and ICC = 0.99 (RDC = 3.8%) for Protocol 2. Increased variability in PDFF measurements was observed with increasing PDFF and especially with higher R2*. Excellent agreement was observed for R2* between centers, vendors, field strengths, and protocols (ICC = 0.99). Stratified by protocol, strong agreement was observed, with ICC = 0.988 (RDC = 66.7 s−1) for Protocol 1 and ICC = 0.99 (RDC = 57.7 s−1) for Protocol 2. Higher variability in R2* measurements was observed in vials with higher PDFF or R2*. Stability tests demonstrated an ICC = 1.0 for PDFF and R2*, and RC of 0.4% for PDFF and 12 s−1 for R2*.

Data Conclusion

Excellent PDFF and R2* reproducibility was observed across centers, vendors, field strengths, and acquisition protocols. Reproducibility decreased slightly with increasing PDFF and R2*, especially for PDFF measurements in vials with high R2*.

Evidence Level

N/A.

Technical Efficacy

Stage 1.

Найдено 
Найдено 

Вы ученый?

Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
1
Поделиться
Цитировать
ГОСТ |
Цитировать
ГОСТ Скопировать
Starekova J. et al. Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom // Journal of Magnetic Resonance Imaging. 2025. Vol. 62. No. 3. pp. 800-811.
ГОСТ со всеми авторами (до 50) Скопировать
Starekova J., Rutkowski D. R., Bae W. K., Do H. P., Madhuranthakam A. J., Malis V., Lin S., Serai S., Yokoo T., Reeder S. B., Brittain J. H., Hernando D. Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom // Journal of Magnetic Resonance Imaging. 2025. Vol. 62. No. 3. pp. 800-811.
RIS |
Цитировать
RIS Скопировать
TY - JOUR
DO - 10.1002/jmri.29775
UR - https://onlinelibrary.wiley.com/doi/10.1002/jmri.29775
TI - Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom
T2 - Journal of Magnetic Resonance Imaging
AU - Starekova, Jitka
AU - Rutkowski, David R
AU - Bae, W K
AU - Do, Hung Phi
AU - Madhuranthakam, Ananth J.
AU - Malis, Vadim
AU - Lin, Shengqing
AU - Serai, Suraj
AU - Yokoo, Takeshi
AU - Reeder, Scott B.
AU - Brittain, Jean H
AU - Hernando, Diego
PY - 2025
DA - 2025/04/18
PB - Wiley
SP - 800-811
IS - 3
VL - 62
SN - 1053-1807
SN - 1522-2586
ER -
BibTex |
Цитировать
BibTex (до 50 авторов) Скопировать
@article{2025_Starekova,
author = {Jitka Starekova and David R Rutkowski and W K Bae and Hung Phi Do and Ananth J. Madhuranthakam and Vadim Malis and Shengqing Lin and Suraj Serai and Takeshi Yokoo and Scott B. Reeder and Jean H Brittain and Diego Hernando},
title = {Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom},
journal = {Journal of Magnetic Resonance Imaging},
year = {2025},
volume = {62},
publisher = {Wiley},
month = {apr},
url = {https://onlinelibrary.wiley.com/doi/10.1002/jmri.29775},
number = {3},
pages = {800--811},
doi = {10.1002/jmri.29775}
}
MLA
Цитировать
MLA Скопировать
Starekova, Jitka, et al. “Multi‐Center, Multi‐Vendor Validation of Simultaneous MRI‐Based Proton Density Fat Fraction and R2* Mapping Using a Combined Proton Density Fat Fraction‐R2* Phantom.” Journal of Magnetic Resonance Imaging, vol. 62, no. 3, Apr. 2025, pp. 800-811. https://onlinelibrary.wiley.com/doi/10.1002/jmri.29775.