Synthesis and Cytotoxicity of 6-Selenopurine Arabinoside and Related Compounds
1
Division of Biological and Medical Sciences, Brown Uniuersity, Providence, RI 02912
|
Publication type: Journal Article
Publication date: 1975-08-01
scimago Q1
wos Q2
SJR: 0.737
CiteScore: 7.2
Impact factor: 3.8
ISSN: 00223549, 15206017
PubMed ID:
1171219
Pharmaceutical Science
Abstract
Abstract
6-Chloro-9-(β-D-arabinofuranosyl)purine served as an intermediate for the chemical synthesis of a series of 6-substituted selenopurine arabinosides. In an in vitro test using murine leukemic cells (L-5178Y) these 6-substituted selenopurine arabinosides showed some cytotoxicity. Lengthening the side chain had no effect on their cytotoxicity. Selenourea was a useful reagent for synthesizing selenopurines, selenopurine nucleosides, and selenopurine arabinoside under mild conditions.Found
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Chu S., Shiue C., Chu M. Yu. Synthesis and Cytotoxicity of 6-Selenopurine Arabinoside and Related Compounds // Journal of Pharmaceutical Sciences. 1975. Vol. 64. No. 8. pp. 1343-1346.
GOST all authors (up to 50)
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Chu S., Shiue C., Chu M. Yu. Synthesis and Cytotoxicity of 6-Selenopurine Arabinoside and Related Compounds // Journal of Pharmaceutical Sciences. 1975. Vol. 64. No. 8. pp. 1343-1346.
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RIS
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TY - JOUR
DO - 10.1002/jps.2600640818
UR - https://doi.org/10.1002/jps.2600640818
TI - Synthesis and Cytotoxicity of 6-Selenopurine Arabinoside and Related Compounds
T2 - Journal of Pharmaceutical Sciences
AU - Chu, Shih-Hsi
AU - Shiue, Chyng-Yann
AU - Chu, Ming Yu
PY - 1975
DA - 1975/08/01
PB - Elsevier
SP - 1343-1346
IS - 8
VL - 64
PMID - 1171219
SN - 0022-3549
SN - 1520-6017
ER -
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BibTex (up to 50 authors)
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@article{1975_Chu,
author = {Shih-Hsi Chu and Chyng-Yann Shiue and Ming Yu Chu},
title = {Synthesis and Cytotoxicity of 6-Selenopurine Arabinoside and Related Compounds},
journal = {Journal of Pharmaceutical Sciences},
year = {1975},
volume = {64},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1002/jps.2600640818},
number = {8},
pages = {1343--1346},
doi = {10.1002/jps.2600640818}
}
Cite this
MLA
Copy
Chu, Shih-Hsi, et al. “Synthesis and Cytotoxicity of 6-Selenopurine Arabinoside and Related Compounds.” Journal of Pharmaceutical Sciences, vol. 64, no. 8, Aug. 1975, pp. 1343-1346. https://doi.org/10.1002/jps.2600640818.