Open Access
View, volume 2, issue 1, pages 20200030
Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy
1
Department of Chemistry City University of Hong Kong Hong Kong SAR P. R. China
|
2
Shenzhen Research Institute City University of Hong Kong Shenzhen P. R. China
|
Publication type: Journal Article
Publication date: 2020-11-16
Abstract
Platinum (Pt)‐based drugs represent some of the most successful anticancer agents in the clinic, and they have greatly accelerated the development of cancer chemotherapy. The therapeutic efficacy of platinum drugs, however, is limited by their various side effects and the development of drug resistance by cancer cells. To address these limitations, platinum drugs are combined with other therapeutic agents as a first‐line therapy for several types of cancer, and these treatments have achieved inspiring therapeutic outcomes. In some cases, however, such combinatorial treatments are inefficacious, due to the severe side effects, the short circulation half‐lives, and the different pharmacokinetic properties of the combined drugs. The rapid development of nanotechnology brings opportunities to surmount these limitations. Coloading platinum drugs and other anticancer agents into nanoparticles not only increases their synergistic efficacy but also improves their pharmacokinetic properties, tumor‐targeting efficiency, and other attributes that are favorable for cancer treatment. In this review, we summarize the recent developments in the application of nanotechnology for combinatorial therapy involving platinum drugs, with a focus on the design, anticancer efficacy, and other advantages of nanoparticles combining platinum drugs and other bioactive moieties. We also discuss the current challenges of these approaches and the prospects for their further development. Our summary and outlook will assist researchers to generate new ideas for the development of highly potent anticancer nanomedicine containing Pt‐based drugs.
Citations by journals
|
1
2
3
4
|
|
|
Small Methods
|
Small Methods
4 publications, 14.81%
|
|
Coordination Chemistry Reviews
|
Coordination Chemistry Reviews
3 publications, 11.11%
|
|
View
|
View
2 publications, 7.41%
|
|
Journal of Materials Chemistry B
|
Journal of Materials Chemistry B
2 publications, 7.41%
|
|
Advanced Science
|
Advanced Science
2 publications, 7.41%
|
|
Molecules
|
Molecules
1 publication, 3.7%
|
|
Frontiers in Physiology
|
Frontiers in Physiology
1 publication, 3.7%
|
|
Biomedical Materials (Bristol)
|
Biomedical Materials (Bristol)
1 publication, 3.7%
|
|
Advanced NanoBiomed Research
|
Advanced NanoBiomed Research
1 publication, 3.7%
|
|
Angewandte Chemie - International Edition
|
Angewandte Chemie - International Edition
1 publication, 3.7%
|
|
Angewandte Chemie
|
Angewandte Chemie
1 publication, 3.7%
|
|
Drug Delivery
|
Drug Delivery
1 publication, 3.7%
|
|
Journal of Controlled Release
|
Journal of Controlled Release
1 publication, 3.7%
|
|
Advanced healthcare materials
|
Advanced healthcare materials
1 publication, 3.7%
|
|
Current Women's Health Reviews
|
Current Women's Health Reviews
1 publication, 3.7%
|
|
Advanced Materials
|
Advanced Materials
1 publication, 3.7%
|
|
Small
|
Small
1 publication, 3.7%
|
|
e-Prime - Advances in Electrical Engineering Electronics and Energy
|
e-Prime - Advances in Electrical Engineering Electronics and Energy
1 publication, 3.7%
|
|
1
2
3
4
|
Citations by publishers
|
2
4
6
8
10
12
14
|
|
|
Wiley
|
Wiley
14 publications, 51.85%
|
|
Elsevier
|
Elsevier
5 publications, 18.52%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
2 publications, 7.41%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 3.7%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 3.7%
|
|
IOP Publishing
|
IOP Publishing
1 publication, 3.7%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 3.7%
|
|
Bentham Science
|
Bentham Science
1 publication, 3.7%
|
|
2
4
6
8
10
12
14
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2021,2022,2023,2024],"ids":[0,0,0,0],"codes":[0,0,0,0],"imageUrls":["","","",""],"datasets":[{"label":"Citations number","data":[4,5,13,5],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["14.81","18.52","48.15","18.52"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Small Methods","Coordination Chemistry Reviews","View","Journal of Materials Chemistry B","Advanced Science","Molecules","Frontiers in Physiology","Biomedical Materials (Bristol)","Advanced NanoBiomed Research","Angewandte Chemie - International Edition","Angewandte Chemie","Drug Delivery","Journal of Controlled Release","Advanced healthcare materials","Current Women's Health Reviews","Advanced Materials","Small","e-Prime - Advances in Electrical Engineering Electronics and Energy"],"ids":[4145,13437,27470,11516,4130,1770,15670,13063,25318,19215,25450,14854,14351,21975,1302,25159,9872,35438],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[4,3,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[14.81,11.11,7.41,7.41,7.41,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7,3.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Wiley","Elsevier","Royal Society of Chemistry (RSC)","Multidisciplinary Digital Publishing Institute (MDPI)","Frontiers Media S.A.","IOP Publishing","Taylor & Francis","Bentham Science"],"ids":[11,17,123,202,208,2075,18,39],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/LsKy6OnmmmRGcAU6CZgWQvNiP1polbaSLNrN7zqj_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp"],"datasets":[{"label":"","data":[14,5,2,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[51.85,18.52,7.41,3.7,3.7,3.7,3.7,3.7],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Deng Z. et al. Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy // View. 2020. Vol. 2. No. 1. p. 20200030.
GOST all authors (up to 50)
Copy
Deng Z., Wang N., Ai F., Wang Z., Zhu G. Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy // View. 2020. Vol. 2. No. 1. p. 20200030.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1002/VIW.20200030
UR - https://doi.org/10.1002%2FVIW.20200030
TI - Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy
T2 - View
AU - Deng, Zhiqin
AU - Wang, Na
AU - Ai, Fujin
AU - Wang, Zhigang
AU - Zhu, Guangyu
PY - 2020
DA - 2020/11/16 00:00:00
PB - Wiley
SP - 20200030
IS - 1
VL - 2
SN - 2688-268X
SN - 2688-268X
ER -
Cite this
BibTex
Copy
@article{2020_Deng,
author = {Zhiqin Deng and Na Wang and Fujin Ai and Zhigang Wang and Guangyu Zhu},
title = {Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy},
journal = {View},
year = {2020},
volume = {2},
publisher = {Wiley},
month = {nov},
url = {https://doi.org/10.1002%2FVIW.20200030},
number = {1},
pages = {20200030},
doi = {10.1002/VIW.20200030}
}
Cite this
MLA
Copy
Deng, Zhiqin, et al. “Nanomaterial‐mediated platinum drug‐based combinatorial cancer therapy.” View, vol. 2, no. 1, Nov. 2020, p. 20200030. https://doi.org/10.1002%2FVIW.20200030.