Angewandte Chemie - International Edition, volume 58, issue 38, pages 13394-13399

Stable J-aggregation of an aza-BODIPY-lipid in a liposome for optical cancer imaging.

Cheng Miffy H. Y. ¹

Harmatys Kara M ¹

Charron Danielle M ^{1, 2}

Chen Juan ¹

Zheng Gang ^{1, 2, 3}

Hide authors affiliations Show authors affiliations: 3 affiliations

Princess Margaret Cancer CentreUniversity Health Network 101 College Street, PMCRT 5-354 Toronto ON M5G 1L7 Canada |

Institute of Biomaterials and Biomedical EngineeringUniversity of Toronto 64 College St. Toronto ON M5S 3G9 Canada |

Department of Medical BiophysicsUniversity of Toronto 101 College St. Toronto ON M5G 1L7 Canada |

Publication type: Journal Article

Publication date: 2019-09-16

Wiley

Journal: Angewandte Chemie - International Edition

Quartile SCImago

Quartile WOS

Impact factor: 16.6

ISSN: 14337851, 15213773

DOI: 10.1002/anie.201907754

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General Chemistry

Catalysis

Abstract

Organic building blocks are the centerpieces of "one-for-all" nanoparticle development, wherein their self-assembly into a nanostructure can induce novel nanoscale properties and advance design of nanoparticles for cancer imaging. Herein, we report the synthesis of a novel aza-BODIPY-lipid building block and its self-assembly into a liposomal nanoparticle (BODIPYsome). We observed optically stable NIR J-aggregation within the BODIPYsome that is likely attributed to J-dimerization. BODIPYsomes with cholesterol showed enhanced colloidal stability while maintaining a high extinction coefficient (128 mM-1 cm-1) and high fluorescence quenching (99.70 ± 0.09%), which enables photoacoustic (PA) properties from its intact structure and recovered NIR fluorescence properties when it is disrupted in cancer cells. Finally, its capabilities for optical imaging (PA/fluorescence) were observed in an orthotopic prostate tumor mouse model 24 h after intravenous administration. Overall, the BODIPYsome opens the door for engineering new building blocks in the design of optically stable biophotonic imaging agents.

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Springer Nature	Springer Nature, 3, 2.88% Springer Nature 3 publications, 2.88%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 0.96% American Institute of Physics (AIP) 1 publication, 0.96%
IOP Publishing	IOP Publishing, 1, 0.96% IOP Publishing 1 publication, 0.96%
Dove Medical Press	Dove Medical Press, 1, 0.96% Dove Medical Press 1 publication, 0.96%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 0.96% American Association for the Advancement of Science (AAAS) 1 publication, 0.96%
	5 10 15 20 25 30 35 40 45

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Cheng M. H. Y. et al. Stable J-aggregation of an aza-BODIPY-lipid in a liposome for optical cancer imaging. // Angewandte Chemie - International Edition. 2019. Vol. 58. No. 38. pp. 13394-13399.

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Cheng M. H. Y., Harmatys K. M., Charron D. M., Chen J., Zheng G. Stable J-aggregation of an aza-BODIPY-lipid in a liposome for optical cancer imaging. // Angewandte Chemie - International Edition. 2019. Vol. 58. No. 38. pp. 13394-13399.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1002/anie.201907754

UR - https://doi.org/10.1002%2Fanie.201907754

TI - Stable J-aggregation of an aza-BODIPY-lipid in a liposome for optical cancer imaging.

T2 - Angewandte Chemie - International Edition

AU - Cheng, Miffy H. Y.

AU - Harmatys, Kara M

AU - Zheng, Gang

AU - Charron, Danielle M

AU - Chen, Juan

PY - 2019

DA - 2019/09/16 00:00:00

PB - Wiley

SP - 13394-13399

IS - 38

VL - 58

SN - 1433-7851

SN - 1521-3773

ER -

BibTex |

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BibTex Copy

@article{2019_Cheng,

author = {Miffy H. Y. Cheng and Kara M Harmatys and Gang Zheng and Danielle M Charron and Juan Chen},

title = {Stable J-aggregation of an aza-BODIPY-lipid in a liposome for optical cancer imaging.},

journal = {Angewandte Chemie - International Edition},

year = {2019},

volume = {58},

publisher = {Wiley},

month = {sep},

url = {https://doi.org/10.1002%2Fanie.201907754},

number = {38},

pages = {13394--13399},

doi = {10.1002/anie.201907754}

}

MLA

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MLA Copy

Cheng, Miffy H. Y., et al. “Stable J-aggregation of an aza-BODIPY-lipid in a liposome for optical cancer imaging..” Angewandte Chemie - International Edition, vol. 58, no. 38, Sep. 2019, pp. 13394-13399. https://doi.org/10.1002%2Fanie.201907754.

Found error?

Publisher

Wiley

Journal

Angewandte Chemie - International Edition

Quartile SCImago

Quartile WOS

Impact factor

16.6

ISSN

14337851 (Print)
15213773 (Electronic)