Current protocols in mouse biology, volume 10, issue 1

A Novel One‐Day Learning Procedure for Mice

Darvas Martin 1
Mukherjee Kishore 2
Lee Amanda 2
Ladiges Warren C. 2
1
 
Department of Pathology University of Washington Seattle Washington
2
 
Department of Comparative Medicine University of Washington Seattle Washington
Publication typeJournal Article
Publication date2020-02-25
Quartile SCImago
Q2
Quartile WOS
Impact factor
ISSN21612617
General Medicine
Abstract
Current preclinical cognitive assessments are highly time intensive, with lengthy assessment procedures. In this regard, a single‐day assay that focuses just on assessing learning behavior in a time‐effective and relatable manner would be of value. This article describes the box maze as a short‐term behavioral procedure to measure learning in mice. The protocol consists of allowing mice to explore an enclosed space that has eight holes. One of these holes leads to a tunnel that connects to an escape cage, and the latency to enter this escape hole is recorded for each mouse. Mice are tested four times within a single day, and the decrease in escape latency over time is used as a measure of learning. Age is a factor that affects escape latency in the box maze. Hence, the box‐maze procedure is proposed as an efficient test to probe aging and aging intervention–related research questions. © 2020 by John Wiley & Sons, Inc.

Citations by journals

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International Journal of Molecular Sciences
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Scientific Reports
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Citations by publishers

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Springer Nature
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Springer Nature
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Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 1, 9.09%
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1 publication, 9.09%
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2
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Darvas M. et al. A Novel One‐Day Learning Procedure for Mice // Current protocols in mouse biology. 2020. Vol. 10. No. 1.
GOST all authors (up to 50) Copy
Darvas M., Mukherjee K., Lee A., Ladiges W. C. A Novel One‐Day Learning Procedure for Mice // Current protocols in mouse biology. 2020. Vol. 10. No. 1.
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RIS Copy
TY - JOUR
DO - 10.1002/cpmo.68
UR - https://doi.org/10.1002%2Fcpmo.68
TI - A Novel One‐Day Learning Procedure for Mice
T2 - Current protocols in mouse biology
AU - Mukherjee, Kishore
AU - Lee, Amanda
AU - Darvas, Martin
AU - Ladiges, Warren C.
PY - 2020
DA - 2020/02/25 00:00:00
PB - Wiley
IS - 1
VL - 10
SN - 2161-2617
ER -
BibTex
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BibTex Copy
@article{2020_Darvas
author = {Kishore Mukherjee and Amanda Lee and Martin Darvas and Warren C. Ladiges},
title = {A Novel One‐Day Learning Procedure for Mice},
journal = {Current protocols in mouse biology},
year = {2020},
volume = {10},
publisher = {Wiley},
month = {feb},
url = {https://doi.org/10.1002%2Fcpmo.68},
number = {1},
doi = {10.1002/cpmo.68}
}
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