Open Access
Genesis, volume 53, issue 2, pages 203-224
Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3
1
Department of Basic Science; Craniofacial Biology; College of Dentistry New York University New York New York
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2
Institut Curie; Centre Universitaire; Batiment 110 F-91 405 Orsay cedex France
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3
Université Paris Sud; Batiment 110 F-91 405 Orsay cedex France
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4
CNRS UMR3347; Centre Universitaire; Batiment 110 F-91 405 Orsay cedex France
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5
INSERM U1021; Centre Universitaire; Batiment 110 F-91 405 Orsay cedex France
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Publication type: Journal Article
Publication date: 2015-01-29
Cell Biology
Genetics
Endocrinology
Abstract
Despite its tremendous complexity, the vertebrate nervous system emerges from a homogenous layer of neuroepithelial cells, the neural plate. Its formation relies on the time‐ and space‐controlled progression of developmental programs. Apoptosis is a biological process that removes superfluous and potentially dangerous cells and is implemented through the activation of a molecular pathway conserved during evolution. Apoptosis and an unconventional function of one of its main effectors, caspase‐3, contribute to the patterning and growth of the neuroepithelium. Little is known about the intrinsic and extrinsic cues controlling activities of the apoptotic machinery during development. The BarH‐like (Barhl) proteins are homeodomain‐containing transcription factors. The observations in Caenorhabditis elegans, Xenopus, and mice document that Barhl proteins act in cell survival and as cell type‐specific regulators of a caspase‐3 function that limits neural progenitor proliferation. In this review, we discuss the roles and regulatory modes of the apoptotic machinery in the development of the neural plate. We focus on the Barhl2, the Sonic Hedgehog, and the Wnt pathways and their activities in neural progenitor survival and proliferation. genesis 53:203–224, 2015. © 2015 Wiley Periodicals, Inc.
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Juraver Geslin H. A. et al. Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3 // Genesis. 2015. Vol. 53. No. 2. pp. 203-224.
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Juraver Geslin H. A., Durand B. C. Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3 // Genesis. 2015. Vol. 53. No. 2. pp. 203-224.
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TY - JOUR
DO - 10.1002/dvg.22844
UR - https://doi.org/10.1002%2Fdvg.22844
TI - Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3
T2 - Genesis
AU - Juraver Geslin, Hugo A
AU - Durand, Béatrice C
PY - 2015
DA - 2015/01/29 00:00:00
PB - Wiley
SP - 203-224
IS - 2
VL - 53
SN - 1526-954X
SN - 1526-968X
SN - 1167-5101
SN - 2268-1590
ER -
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@article{2015_Juraver Geslin
author = {Hugo A Juraver Geslin and Béatrice C Durand},
title = {Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3},
journal = {Genesis},
year = {2015},
volume = {53},
publisher = {Wiley},
month = {jan},
url = {https://doi.org/10.1002%2Fdvg.22844},
number = {2},
pages = {203--224},
doi = {10.1002/dvg.22844}
}
Cite this
MLA
Copy
Juraver Geslin, Hugo A., et al. “Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase-3.” Genesis, vol. 53, no. 2, Jan. 2015, pp. 203-224. https://doi.org/10.1002%2Fdvg.22844.