Journal of Applied Toxicology, volume 39, issue 1, pages 38-71

In vitro assays and techniques utilized in anticancer drug discovery

EDIRIWEERA MERAN KESHAWA 1
TENNEKOON KAMANI H. 1
SAMARAKOON SAMEERA RANGANATH 1
1
 
Institute of Biochemistry, Molecular Biology and Biotechnology; University of Colombo; Colombo 03 Sri Lanka
Publication typeJournal Article
Publication date2018-08-02
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor3.3
ISSN0260437X, 10991263
Toxicology
Abstract
Development of a cancer is a multistep process and six major hallmarks of cancer that are known to control malignant transformation have been described. Anticancer drug development is a tedious process, requiring a number of in vitro, in vivo and clinical studies. In vitro assays provide an initial platform for cancer drug discovery approaches. A wide range of in vitro assays/techniques have been developed to evaluate each hallmark feature of cancer and selection of a particular in vitro assay or technique mainly depends on the specific research question (s) to be examined. In the present review, we have described some commonly utilized in vitro assays and techniques used to examine cell viability/proliferation, apoptosis, cellular senescence, invasion and migration, oxidative stress and antioxidant effects, gene and protein expression, angiogenesis and genomic alterations in cancer drug discovery. Additionally, uses of modern techniques such as high throughput screening, high content screening and reporter gene assays in cancer drug discovery have also been described.

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EDIRIWEERA M. K., TENNEKOON K. H., SAMARAKOON S. R. In vitro assays and techniques utilized in anticancer drug discovery // Journal of Applied Toxicology. 2018. Vol. 39. No. 1. pp. 38-71.
GOST all authors (up to 50) Copy
EDIRIWEERA M. K., TENNEKOON K. H., SAMARAKOON S. R. In vitro assays and techniques utilized in anticancer drug discovery // Journal of Applied Toxicology. 2018. Vol. 39. No. 1. pp. 38-71.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/jat.3658
UR - https://doi.org/10.1002%2Fjat.3658
TI - In vitro assays and techniques utilized in anticancer drug discovery
T2 - Journal of Applied Toxicology
AU - EDIRIWEERA, MERAN KESHAWA
AU - TENNEKOON, KAMANI H.
AU - SAMARAKOON, SAMEERA RANGANATH
PY - 2018
DA - 2018/08/02 00:00:00
PB - Wiley
SP - 38-71
IS - 1
VL - 39
SN - 0260-437X
SN - 1099-1263
ER -
BibTex |
Cite this
BibTex Copy
@article{2018_EDIRIWEERA
author = {MERAN KESHAWA EDIRIWEERA and KAMANI H. TENNEKOON and SAMEERA RANGANATH SAMARAKOON},
title = {In vitro assays and techniques utilized in anticancer drug discovery},
journal = {Journal of Applied Toxicology},
year = {2018},
volume = {39},
publisher = {Wiley},
month = {aug},
url = {https://doi.org/10.1002%2Fjat.3658},
number = {1},
pages = {38--71},
doi = {10.1002/jat.3658}
}
MLA
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MLA Copy
EDIRIWEERA, MERAN KESHAWA, et al. “In vitro assays and techniques utilized in anticancer drug discovery.” Journal of Applied Toxicology, vol. 39, no. 1, Aug. 2018, pp. 38-71. https://doi.org/10.1002%2Fjat.3658.
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