Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells

Sokol M.B., Nikolskaya E.D., Yabbarov N.G., Zenin V.A., Faustova M.R., Belov A.V., Zhunina O.A., Mollaev M.D., Zabolotsky A.I., Tereshchenko O.G., Severin E.S.
Тип документаJournal Article
Дата публикации2018-10-03
Название журналаJournal of Biomedical Materials Research - Part B Applied Biomaterials
ИздательWiley-Blackwell
Квартиль по SCImagoQ2
Квартиль по Web of ScienceQ3
Импакт-фактор 20213.41
ISSN15524973, 15524981
Biomaterials
Biomedical Engineering
Краткое описание
Co-encapsulation of abiraterone acetate (AbrA) and docetaxel (Dtx) in polymeric nanoparticles as novel prototypes for prostate cancer treatment combining hormonal and chemotherapy was designed. Nanoparticles (NPs) composed of poly(dl-lactide-co-glycolide) (PLGA) were prepared by single-emulsion solvent evaporation technique and characterized in terms of morphology with atomic force microscopy and transmission electron microscopy. HPLC method for simultaneous determination of AbrA and Dtx encapsulation efficacy was developed. Also differential scanning calorimetry and Fourier-transform infrared spectroscopy were provided. To study the effectiveness of cellular internalization and distribution of NPs with AbrA and Dtx co-encapsulation (NP-AbrA/Dtx), a fluorescence microscopy was utilized. NPs prepared had size 256.3 ±9.4 nm and zeta potential -18.4 ±1.4 mV. Encapsulation efficacy for AbrA was 68.7% and for Dtx was 74.3%. NPs were able to control the AbrA and Dtx release within 24 h. The mathematical model of drug release was performed. The results obtained from confocal microscopy showed the effective accumulation of the NP-AbrA/Dtx in the cytoplasm of cells. Synthesized NPs possessed satisfactory parameters and a biphasic release profile, proceeding by the Fick diffusion mechanism, which provide prolonged release of the drugs and maintenance of their concentration. It was shown that NPs loaded with AbrA and Dtx exhibited a high cytotoxic activity on the LNCaP cell line, similar to the combination of free drugs of AbrA and Dtx, but in contrast to the combination of substances, had a synergistic mechanism of action. Our findings support the potential use of developed NPs in further in vivo studies. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1150-1158, 2019.
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1. Sokol M.B. и др. Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells // Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2018. Т. 107. № 4. С. 1150–1158.
RIS |
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TY - JOUR

DO - 10.1002/jbm.b.34208

UR - http://dx.doi.org/10.1002/jbm.b.34208

TI - Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells

T2 - Journal of Biomedical Materials Research Part B: Applied Biomaterials

AU - Sokol, Mariya B.

AU - Nikolskaya, Elena D.

AU - Yabbarov, Nikita G.

AU - Zenin, Vladimir A.

AU - Faustova, Mariya R.

AU - Belov, Alexey V.

AU - Zhunina, Olga A.

AU - Mollaev, Murad D.

AU - Zabolotsky, Artur I.

AU - Tereshchenko, Oksana G.

AU - Severin, Eugen S.

PY - 2018

DA - 2018/10/03

PB - Wiley

SP - 1150-1158

IS - 4

VL - 107

SN - 1552-4973

SN - 1552-4981

ER -

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@article{Sokol_2018,

doi = {10.1002/jbm.b.34208},

url = {https://doi.org/10.1002%2Fjbm.b.34208},

year = 2018,

month = {oct},

publisher = {Wiley},

volume = {107},

number = {4},

pages = {1150--1158},

author = {Mariya B. Sokol and Elena D. Nikolskaya and Nikita G. Yabbarov and Vladimir A. Zenin and Mariya R. Faustova and Alexey V. Belov and Olga A. Zhunina and Murad D. Mollaev and Artur I. Zabolotsky and Oksana G. Tereshchenko and Eugen S. Severin},

title = {Development of novel {PLGA} nanoparticles with co-encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells},

journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials}

}

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Sokol, Mariya B. et al. “Development of Novel PLGA Nanoparticles with Co‐encapsulation of Docetaxel and Abiraterone Acetate for a Highly Efficient Delivery into Tumor Cells.” Journal of Biomedical Materials Research Part B: Applied Biomaterials 107.4 (2018): 1150–1158. Crossref. Web.