Journal of Biomedical Materials Research - Part B Applied Biomaterials, volume 109, issue 4, pages 527-537

Fabrication and evaluation of nanocontainers for lipophilic anticancer drug delivery in 3D in vitro model.

Borodina T N 1, 2
Gileva Anastasia 3
Akasov Roman A. 1, 2, 3, 4
Trushina Daria 1, 2
Burov Sergey 5
González Alfaro Yorexis 7
Bukreeva Tatiana 1, 8
Markvicheva E. 3
Publication typeJournal Article
Publication date2020-09-17
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor3.4
ISSN15524973, 15524981
Biomaterials
Biomedical Engineering
Abstract
Presently, most of anticancer drugs are high toxic for normal cells and, and as a result, they have severe side effects. Moreover, most of the formulations are lipophilic and have poor selectivity. To overcome these limitations, various drug delivery systems could be proposed. The aim of the current study was to fabricate novel polysaccharide nanocontainers (NC) by one-step ultrasonication technique and to evaluate their accumulation efficacy and cytotoxicity in 2D (monolayer culture) and 3D (tumor spheroids) in vitro models. NC with mean sizes in a range of 340-420 nm with the core-shell structure are synthetized and characterized. The NC shell is composed from diethylaminoethyl dextran/xanthan gum polyelectrolyte complex, while the hydrophobic core was loaded with the lipophilic anticancer drug thymoquinone. To enhance NC accumulation in human breast adenocarcinoma MCF-7 cells, the NC surface was modified with poly-L-lysine (PLL) or polyethylene glycol. Cell uptake of the NC loaded with Nile Red into the tumor cells was investigated by laser scanning confocal microscopy, fluorescent flow cytometry and fluorimetry. Modification of the NC with PLL allowed to obtain the optimal drug delivery system with maximal cytotoxicity, which was tested by MTT-test. The developed NC are promising for lipophilic anticancer drug delivery.

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Borodina T. N. et al. Fabrication and evaluation of nanocontainers for lipophilic anticancer drug delivery in 3D in vitro model. // Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2020. Vol. 109. No. 4. pp. 527-537.
GOST all authors (up to 50) Copy
Borodina T. N., Gileva A., Akasov R. A., Trushina D., Burov S., Klyachko N. L., González Alfaro Y., Bukreeva T., Markvicheva E. Fabrication and evaluation of nanocontainers for lipophilic anticancer drug delivery in 3D in vitro model. // Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2020. Vol. 109. No. 4. pp. 527-537.
RIS |
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TY - JOUR
DO - 10.1002/jbm.b.34721
UR - https://doi.org/10.1002%2Fjbm.b.34721
TI - Fabrication and evaluation of nanocontainers for lipophilic anticancer drug delivery in 3D in vitro model.
T2 - Journal of Biomedical Materials Research - Part B Applied Biomaterials
AU - Gileva, Anastasia
AU - González Alfaro, Yorexis
AU - Bukreeva, Tatiana
AU - Borodina, T N
AU - Akasov, Roman A.
AU - Trushina, Daria
AU - Burov, Sergey
AU - Klyachko, Natalia L.
AU - Markvicheva, E.
PY - 2020
DA - 2020/09/17 00:00:00
PB - Wiley
SP - 527-537
IS - 4
VL - 109
SN - 1552-4973
SN - 1552-4981
ER -
BibTex |
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@article{2020_Borodina
author = {Anastasia Gileva and Yorexis González Alfaro and Tatiana Bukreeva and T N Borodina and Roman A. Akasov and Daria Trushina and Sergey Burov and Natalia L. Klyachko and E. Markvicheva},
title = {Fabrication and evaluation of nanocontainers for lipophilic anticancer drug delivery in 3D in vitro model.},
journal = {Journal of Biomedical Materials Research - Part B Applied Biomaterials},
year = {2020},
volume = {109},
publisher = {Wiley},
month = {sep},
url = {https://doi.org/10.1002%2Fjbm.b.34721},
number = {4},
pages = {527--537},
doi = {10.1002/jbm.b.34721}
}
MLA
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MLA Copy
Borodina, T. N., et al. “Fabrication and evaluation of nanocontainers for lipophilic anticancer drug delivery in 3D in vitro model..” Journal of Biomedical Materials Research - Part B Applied Biomaterials, vol. 109, no. 4, Sep. 2020, pp. 527-537. https://doi.org/10.1002%2Fjbm.b.34721.
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