Mass Spectrometry Reviews, volume 41, issue 2, pages 284-313
FT-MS in the de novo top-down sequencing of natural nontryptic peptides
Publication type: Journal Article
Publication date: 2020-12-21
Journal:
Mass Spectrometry Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 6.6
ISSN: 02777037, 10982787
General Biochemistry, Genetics and Molecular Biology
Spectroscopy
Analytical Chemistry
Condensed Matter Physics
Abstract
The present review covers available results on the application of FT-MS for the de novo sequencing of natural peptides of various animals: cones, bees, snakes, amphibians, scorpions, and so forth. As these peptides are usually bioactive, the animals efficiently use them as a weapon against microorganisms or higher animals including predators. These peptides represent definite interest as drugs of future generations since the mechanism of their activity is completely different in comparison with that of the modern antibiotics. Utilization of those peptides as antibiotics can eliminate the problem of the bacterial resistance development. Sequence elucidation of these bioactive peptides becomes even more challenging when the species genome is not available and little is known about the protein origin and other properties of those peptides in the study. De novo sequencing may be the only option to obtain sequence information. The benefits of FT-MS for the top-down peptide sequencing, the general approaches of the de novxxo sequencing, the difficult cases involving sequence coverage, isobaric and isomeric amino acids, cyclization of short peptides, the presence of posttranslational modifications will be discussed in the review.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Lebedev A. T., Vasileva I. D., Samgina T. Y. FT-MS in the de novo top-down sequencing of natural nontryptic peptides // Mass Spectrometry Reviews. 2020. Vol. 41. No. 2. pp. 284-313.
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Lebedev A. T., Vasileva I. D., Samgina T. Y. FT-MS in the de novo top-down sequencing of natural nontryptic peptides // Mass Spectrometry Reviews. 2020. Vol. 41. No. 2. pp. 284-313.
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TY - JOUR
DO - 10.1002/mas.21678
UR - https://doi.org/10.1002%2Fmas.21678
TI - FT-MS in the de novo top-down sequencing of natural nontryptic peptides
T2 - Mass Spectrometry Reviews
AU - Vasileva, Irina D
AU - Samgina, Tatiana Y
AU - Lebedev, Albert T.
PY - 2020
DA - 2020/12/21 00:00:00
PB - Wiley
SP - 284-313
IS - 2
VL - 41
SN - 0277-7037
SN - 1098-2787
ER -
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@article{2020_Lebedev,
author = {Irina D Vasileva and Tatiana Y Samgina and Albert T. Lebedev},
title = {FT-MS in the de novo top-down sequencing of natural nontryptic peptides},
journal = {Mass Spectrometry Reviews},
year = {2020},
volume = {41},
publisher = {Wiley},
month = {dec},
url = {https://doi.org/10.1002%2Fmas.21678},
number = {2},
pages = {284--313},
doi = {10.1002/mas.21678}
}
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Lebedev, Albert T., et al. “FT-MS in the de novo top-down sequencing of natural nontryptic peptides.” Mass Spectrometry Reviews, vol. 41, no. 2, Dec. 2020, pp. 284-313. https://doi.org/10.1002%2Fmas.21678.
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