Medicinal Research Reviews, volume 39, issue 1, pages 40-69
Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy
2
German Cancer Consortium (DKTK); Heidelberg Germany
|
Publication type: Journal Article
Publication date: 2018-05-17
Journal:
Medicinal Research Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 13.3
ISSN: 01986325, 10981128
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
The high incidence rates of prostate cancer (PCa) raise demand for improved therapeutic strategies. Prostate tumors specifically express the prostate-specific membrane antigen (PSMA), a membrane-bound protease. As PSMA is highly overexpressed on malignant prostate tumor cells and as its expression rate correlates with the aggressiveness of the disease, this tumor-associated biomarker provides the possibility to develop new strategies for diagnostics and therapy of PCa. Major advances have been made in PSMA targeting, ranging from immunotherapeutic approaches to therapeutic small molecules. This review elaborates the diversity of PSMA targeting agents while focusing on the radioactively labeled tracers for diagnosis and endoradiotherapy. A variety of radionuclides have been shown to either enable precise diagnosis or efficiently treat the tumor with minimal effects to nontargeted organs. Most small molecules with affinity for PSMA are based on either a phosphonate or a urea-based binding motif. Based on these pharmacophores, major effort has been made to identify modifications to achieve ideal pharmacokinetics while retaining the specific targeting of the PSMA binding pocket. Several tracers have now shown excellent clinical usability in particular for molecular imaging and therapy as proven by the efficiency of theranostic approaches in current studies. The archetypal expression profile of PSMA may be exploited for the treatment with alpha emitters to break radioresistance and thus to bring the power of systemic therapy to higher levels.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Wüstemann T. et al. Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy // Medicinal Research Reviews. 2018. Vol. 39. No. 1. pp. 40-69.
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Wüstemann T., Haberkorn U., Babich J. W., Mier W. Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy // Medicinal Research Reviews. 2018. Vol. 39. No. 1. pp. 40-69.
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TY - JOUR
DO - 10.1002/med.21508
UR - https://doi.org/10.1002%2Fmed.21508
TI - Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy
T2 - Medicinal Research Reviews
AU - Wüstemann, Till
AU - Haberkorn, Uwe
AU - Mier, Walter
AU - Babich, John W.
PY - 2018
DA - 2018/05/17 00:00:00
PB - Wiley
SP - 40-69
IS - 1
VL - 39
SN - 0198-6325
SN - 1098-1128
ER -
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BibTex
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@article{2018_Wüstemann
author = {Till Wüstemann and Uwe Haberkorn and Walter Mier and John W. Babich},
title = {Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy},
journal = {Medicinal Research Reviews},
year = {2018},
volume = {39},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002%2Fmed.21508},
number = {1},
pages = {40--69},
doi = {10.1002/med.21508}
}
Cite this
MLA
Copy
Wüstemann, Till, et al. “Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy.” Medicinal Research Reviews, vol. 39, no. 1, May. 2018, pp. 40-69. https://doi.org/10.1002%2Fmed.21508.