Medicinal Research Reviews, volume 39, issue 1, pages 40-69

Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy

Wüstemann Till 1
Haberkorn Uwe 1, 2
Babich John W. 3
Mier Walter 1
Publication typeJournal Article
Publication date2018-05-17
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor13.3
ISSN01986325, 10981128
Drug Discovery
Pharmacology
Molecular Medicine
Abstract
The high incidence rates of prostate cancer (PCa) raise demand for improved therapeutic strategies. Prostate tumors specifically express the prostate-specific membrane antigen (PSMA), a membrane-bound protease. As PSMA is highly overexpressed on malignant prostate tumor cells and as its expression rate correlates with the aggressiveness of the disease, this tumor-associated biomarker provides the possibility to develop new strategies for diagnostics and therapy of PCa. Major advances have been made in PSMA targeting, ranging from immunotherapeutic approaches to therapeutic small molecules. This review elaborates the diversity of PSMA targeting agents while focusing on the radioactively labeled tracers for diagnosis and endoradiotherapy. A variety of radionuclides have been shown to either enable precise diagnosis or efficiently treat the tumor with minimal effects to nontargeted organs. Most small molecules with affinity for PSMA are based on either a phosphonate or a urea-based binding motif. Based on these pharmacophores, major effort has been made to identify modifications to achieve ideal pharmacokinetics while retaining the specific targeting of the PSMA binding pocket. Several tracers have now shown excellent clinical usability in particular for molecular imaging and therapy as proven by the efficiency of theranostic approaches in current studies. The archetypal expression profile of PSMA may be exploited for the treatment with alpha emitters to break radioresistance and thus to bring the power of systemic therapy to higher levels.

Citations by journals

1
2
3
4
Pharmaceutics
Pharmaceutics, 4, 5.06%
Pharmaceutics
4 publications, 5.06%
European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 4, 5.06%
European Journal of Nuclear Medicine and Molecular Imaging
4 publications, 5.06%
Molecules
Molecules, 3, 3.8%
Molecules
3 publications, 3.8%
International Journal of Molecular Sciences
International Journal of Molecular Sciences, 3, 3.8%
International Journal of Molecular Sciences
3 publications, 3.8%
Chemistry - A European Journal
Chemistry - A European Journal, 3, 3.8%
Chemistry - A European Journal
3 publications, 3.8%
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2, 2.53%
Journal of Medicinal Chemistry
2 publications, 2.53%
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2, 2.53%
European Journal of Medicinal Chemistry
2 publications, 2.53%
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology, 2, 2.53%
Journal of Cancer Research and Clinical Oncology
2 publications, 2.53%
Amino Acids
Amino Acids, 2, 2.53%
Amino Acids
2 publications, 2.53%
Molecular Therapy - Oncolytics
Molecular Therapy - Oncolytics, 2, 2.53%
Molecular Therapy - Oncolytics
2 publications, 2.53%
Prostate
Prostate, 2, 2.53%
Prostate
2 publications, 2.53%
Small
Small, 2, 2.53%
Small
2 publications, 2.53%
Molecular Pharmaceutics
Molecular Pharmaceutics, 2, 2.53%
Molecular Pharmaceutics
2 publications, 2.53%
Chemical Reviews
Chemical Reviews, 2, 2.53%
Chemical Reviews
2 publications, 2.53%
Journal of Materials Chemistry B
Journal of Materials Chemistry B, 2, 2.53%
Journal of Materials Chemistry B
2 publications, 2.53%
Biomaterials Science
Biomaterials Science, 2, 2.53%
Biomaterials Science
2 publications, 2.53%
Journal of Radiotherapy in Practice
Journal of Radiotherapy in Practice, 2, 2.53%
Journal of Radiotherapy in Practice
2 publications, 2.53%
Current Radiopharmaceuticals
Current Radiopharmaceuticals, 1, 1.27%
Current Radiopharmaceuticals
1 publication, 1.27%
Toxins
Toxins, 1, 1.27%
Toxins
1 publication, 1.27%
Cancers
Cancers, 1, 1.27%
Cancers
1 publication, 1.27%
Chemosensors
Chemosensors, 1, 1.27%
Chemosensors
1 publication, 1.27%
Molecular Biotechnology
Molecular Biotechnology, 1, 1.27%
Molecular Biotechnology
1 publication, 1.27%
Science China Chemistry
Science China Chemistry, 1, 1.27%
Science China Chemistry
1 publication, 1.27%
Nature Reviews Disease Primers
Nature Reviews Disease Primers, 1, 1.27%
Nature Reviews Disease Primers
1 publication, 1.27%
Scientific Reports
Scientific Reports, 1, 1.27%
Scientific Reports
1 publication, 1.27%
Journal of Hazardous Materials
Journal of Hazardous Materials, 1, 1.27%
Journal of Hazardous Materials
1 publication, 1.27%
Seminars in Nuclear Medicine
Seminars in Nuclear Medicine, 1, 1.27%
Seminars in Nuclear Medicine
1 publication, 1.27%
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, 1, 1.27%
Bioorganic and Medicinal Chemistry
1 publication, 1.27%
Annals of Oncology
Annals of Oncology, 1, 1.27%
Annals of Oncology
1 publication, 1.27%
1
2
3
4

Citations by publishers

2
4
6
8
10
12
14
Elsevier
Elsevier, 14, 17.72%
Elsevier
14 publications, 17.72%
Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 14, 17.72%
Multidisciplinary Digital Publishing Institute (MDPI)
14 publications, 17.72%
Wiley
Wiley, 13, 16.46%
Wiley
13 publications, 16.46%
Springer Nature
Springer Nature, 12, 15.19%
Springer Nature
12 publications, 15.19%
American Chemical Society (ACS)
American Chemical Society (ACS), 10, 12.66%
American Chemical Society (ACS)
10 publications, 12.66%
Royal Society of Chemistry (RSC)
Royal Society of Chemistry (RSC), 5, 6.33%
Royal Society of Chemistry (RSC)
5 publications, 6.33%
Cambridge University Press
Cambridge University Press, 2, 2.53%
Cambridge University Press
2 publications, 2.53%
Bentham Science
Bentham Science, 1, 1.27%
Bentham Science
1 publication, 1.27%
Oxford University Press
Oxford University Press, 1, 1.27%
Oxford University Press
1 publication, 1.27%
American Association for Cancer Research (AACR)
American Association for Cancer Research (AACR), 1, 1.27%
American Association for Cancer Research (AACR)
1 publication, 1.27%
Ulyanovsk State University
Ulyanovsk State University, 1, 1.27%
Ulyanovsk State University
1 publication, 1.27%
2
4
6
8
10
12
14
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Wüstemann T. et al. Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy // Medicinal Research Reviews. 2018. Vol. 39. No. 1. pp. 40-69.
GOST all authors (up to 50) Copy
Wüstemann T., Haberkorn U., Babich J. W., Mier W. Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy // Medicinal Research Reviews. 2018. Vol. 39. No. 1. pp. 40-69.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1002/med.21508
UR - https://doi.org/10.1002%2Fmed.21508
TI - Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy
T2 - Medicinal Research Reviews
AU - Wüstemann, Till
AU - Haberkorn, Uwe
AU - Mier, Walter
AU - Babich, John W.
PY - 2018
DA - 2018/05/17 00:00:00
PB - Wiley
SP - 40-69
IS - 1
VL - 39
SN - 0198-6325
SN - 1098-1128
ER -
BibTex |
Cite this
BibTex Copy
@article{2018_Wüstemann
author = {Till Wüstemann and Uwe Haberkorn and Walter Mier and John W. Babich},
title = {Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy},
journal = {Medicinal Research Reviews},
year = {2018},
volume = {39},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002%2Fmed.21508},
number = {1},
pages = {40--69},
doi = {10.1002/med.21508}
}
MLA
Cite this
MLA Copy
Wüstemann, Till, et al. “Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy.” Medicinal Research Reviews, vol. 39, no. 1, May. 2018, pp. 40-69. https://doi.org/10.1002%2Fmed.21508.
Found error?