Small, volume 17, issue 31, pages 2006742
Type I Photosensitizers Revitalizing Photodynamic Oncotherapy.
Publication type: Journal Article
Publication date: 2021-05-26
Abstract
Photodynamic therapy (PDT) has shown great potential for tumor treatment with merits of non-invasiveness, high selectivity, and minimal side effects. However, conventional type II PDT relying on 1 O2 presents poor therapeutic efficacy for hypoxic tumors due to the oxygen-dependent manner. Alternatively, emerging researches have demonstrated that type I PDT exhibits superiority over type II PDT in tumor treatment owing to its diminished oxygen-dependence. In this review, state-of-the-art studies concerning recent progress in type I photosensitizers are scrutinized, emphasizing the strategies to construct highly effective type I photosensitizers. As the foundation, basic principles of type I PDT are presented, and up-to-date type I photosensitizers are summarized and classified based on their attributes. Then, a literature review of representative type I photosensitizers (including nanomaterials and small molecules) is presented with impetus to delineate their novel designs, action mechanisms, as well as anticancer PDT applications. Finally, the remaining challenges and development directions of type I photosensitizers are outlined, highlighting key scientific issues toward clinical translations.
Citations by journals
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Small
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Small
9 publications, 5.33%
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ACS Nano
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ACS Nano
7 publications, 4.14%
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Chemical Engineering Journal
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Chemical Engineering Journal
6 publications, 3.55%
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Journal of Materials Chemistry B
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Journal of Materials Chemistry B
6 publications, 3.55%
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Advanced Materials
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Advanced Materials
6 publications, 3.55%
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Advanced healthcare materials
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Advanced healthcare materials
6 publications, 3.55%
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Biomaterials
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Biomaterials
4 publications, 2.37%
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Journal of Photochemistry and Photobiology A: Chemistry
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Journal of Photochemistry and Photobiology A: Chemistry
4 publications, 2.37%
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Angewandte Chemie - International Edition
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Angewandte Chemie - International Edition
4 publications, 2.37%
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Angewandte Chemie
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Angewandte Chemie
4 publications, 2.37%
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Journal of the American Chemical Society
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Journal of the American Chemical Society
3 publications, 1.78%
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Molecules
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Molecules
3 publications, 1.78%
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Pharmaceutics
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Pharmaceutics
3 publications, 1.78%
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Coordination Chemistry Reviews
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Coordination Chemistry Reviews
3 publications, 1.78%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
3 publications, 1.78%
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Advanced Science
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Advanced Science
3 publications, 1.78%
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ACS Applied Nano Materials
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ACS Applied Nano Materials
3 publications, 1.78%
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Chemical Communications
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Chemical Communications
3 publications, 1.78%
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Chemical Science
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Chemical Science
3 publications, 1.78%
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Materials Chemistry Frontiers
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Materials Chemistry Frontiers
3 publications, 1.78%
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ACS Materials Letters
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ACS Materials Letters
3 publications, 1.78%
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Nature Communications
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Nature Communications
2 publications, 1.18%
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Journal of Controlled Release
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Journal of Controlled Release
2 publications, 1.18%
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Dyes and Pigments
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Dyes and Pigments
2 publications, 1.18%
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Photodiagnosis and Photodynamic Therapy
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Photodiagnosis and Photodynamic Therapy
2 publications, 1.18%
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Advanced Functional Materials
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Advanced Functional Materials
2 publications, 1.18%
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Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry
2 publications, 1.18%
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Analytical Chemistry
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Analytical Chemistry
2 publications, 1.18%
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Biomaterials Science
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Biomaterials Science
2 publications, 1.18%
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Nanophotonics
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Nanophotonics
2 publications, 1.18%
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Citations by publishers
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Wiley
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Wiley
48 publications, 28.4%
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Elsevier
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Elsevier
31 publications, 18.34%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
28 publications, 16.57%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
26 publications, 15.38%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
15 publications, 8.88%
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Springer Nature
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Springer Nature
7 publications, 4.14%
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Frontiers Media S.A.
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Frontiers Media S.A.
3 publications, 1.78%
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Walter de Gruyter
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Walter de Gruyter
3 publications, 1.78%
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Hindawi Limited
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Hindawi Limited
2 publications, 1.18%
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Shenyang Pharmaceutical University
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Shenyang Pharmaceutical University, 1, 0.59%
Shenyang Pharmaceutical University
1 publication, 0.59%
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Dove Medical Press
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Dove Medical Press
1 publication, 0.59%
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American Association for the Advancement of Science (AAAS)
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American Association for the Advancement of Science (AAAS)
1 publication, 0.59%
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Ivanovo State University of Chemistry and Technology
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Ivanovo State University of Chemistry and Technology
1 publication, 0.59%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Chen D. et al. Type I Photosensitizers Revitalizing Photodynamic Oncotherapy. // Small. 2021. Vol. 17. No. 31. p. 2006742.
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Chen D., Xu Q., Wang W., Shao J., Huang W., Dong X. Type I Photosensitizers Revitalizing Photodynamic Oncotherapy. // Small. 2021. Vol. 17. No. 31. p. 2006742.
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TY - JOUR
DO - 10.1002/smll.202006742
UR - https://doi.org/10.1002%2Fsmll.202006742
TI - Type I Photosensitizers Revitalizing Photodynamic Oncotherapy.
T2 - Small
AU - Chen, D
AU - Xu, Q
AU - Wang, W
AU - Shao, J
AU - Huang, W
AU - Dong, X
PY - 2021
DA - 2021/05/26 00:00:00
PB - Wiley
SP - 2006742
IS - 31
VL - 17
SN - 1613-6810
SN - 1613-6829
ER -
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@article{2021,
author = {D Chen and Q Xu and W Wang and J Shao and W Huang and X Dong},
title = {Type I Photosensitizers Revitalizing Photodynamic Oncotherapy.},
journal = {Small},
year = {2021},
volume = {17},
publisher = {Wiley},
month = {may},
url = {https://doi.org/10.1002%2Fsmll.202006742},
number = {31},
pages = {2006742},
doi = {10.1002/smll.202006742}
}