Open Access
Open access
Wiley interdisciplinary reviews. RNA, volume 12, issue 2

The multifaceted role of PARP1 in RNA biogenesis

Eleazer Rebekah 1
Fondufe Mittendorf Yvonne N 1
1
 
Department of Molecular and Cellular Biochemistry and Markey Cancer Center University of Kentucky Lexington Kentucky USA
Publication typeJournal Article
Publication date2020-07-12
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor7.3
ISSN17577004, 17577012
PubMed ID:  32656996
Biochemistry
Molecular Biology
Abstract
Poly(ADP‐ribose) polymerases (PARPs) are abundant nuclear proteins that synthesize ADP ribose polymers (pADPr) and catalyze the addition of (p)ADPr to target biomolecules. PARP1, the most abundant and well‐studied PARP, is a multifunctional enzyme that participates in numerous critical cellular processes. A considerable amount of PARP research has focused on PARP1's role in DNA damage. However, an increasing body of evidence outlines more routine roles for PARP and PARylation in nearly every step of RNA biogenesis and metabolism. PARP1's involvement in these RNA processes is pleiotropic and has been ascribed to PARP1's unique flexible domain structures. PARP1 domains are modular self‐arranged enabling it to recognize structurally diverse substrates and to act simultaneously through multiple discrete mechanisms. These mechanisms include direct PARP1‐protein binding, PARP1‐nucleic acid binding, covalent PARylation of target molecules, covalent autoPARylation, and induction of noncovalent interactions with PAR molecules. A combination of these mechanisms has been implicated in PARP1's context‐specific regulation of RNA biogenesis and metabolism. We examine the mechanisms of PARP1 regulation in transcription initiation, elongation and termination, co‐transcriptional splicing, RNA export, and post‐transcriptional RNA processing. Finally, we consider promising new investigative avenues for PARP1 involvement in these processes with an emphasis on PARP1 regulation of subcellular condensates.

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GOST Copy
Eleazer R., Fondufe Mittendorf Y. N. The multifaceted role of PARP1 in RNA biogenesis // Wiley interdisciplinary reviews. RNA. 2020. Vol. 12. No. 2.
GOST all authors (up to 50) Copy
Eleazer R., Fondufe Mittendorf Y. N. The multifaceted role of PARP1 in RNA biogenesis // Wiley interdisciplinary reviews. RNA. 2020. Vol. 12. No. 2.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1002/wrna.1617
UR - https://doi.org/10.1002%2Fwrna.1617
TI - The multifaceted role of PARP1 in RNA biogenesis
T2 - Wiley interdisciplinary reviews. RNA
AU - Eleazer, Rebekah
AU - Fondufe Mittendorf, Yvonne N
PY - 2020
DA - 2020/07/12 00:00:00
PB - Wiley
IS - 2
VL - 12
PMID - 32656996
SN - 1757-7004
SN - 1757-7012
ER -
BibTex
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BibTex Copy
@article{2020_Eleazer
author = {Rebekah Eleazer and Yvonne N Fondufe Mittendorf},
title = {The multifaceted role of PARP1 in RNA biogenesis},
journal = {Wiley interdisciplinary reviews. RNA},
year = {2020},
volume = {12},
publisher = {Wiley},
month = {jul},
url = {https://doi.org/10.1002%2Fwrna.1617},
number = {2},
doi = {10.1002/wrna.1617}
}
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