Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom
A B Soliev
1
,
Sh.Ya. Mirzaakhmedov
1
,
M S Tashmukhamedov
1
,
F G Kamaev
1
,
Sh I Salikhov
1
,
N I Zakirova
2
,
A Yu Abramov
2
,
I V Usanova
2
,
V. N. Syrov
2
,
Z. A. Khushbaktova
2
Publication type: Journal Article
Publication date: 2007-11-01
scimago Q4
wos Q4
SJR: 0.219
CiteScore: 1.4
Impact factor: 1.0
ISSN: 0091150X, 15739031
Drug Discovery
Pharmacology
Abstract
The chemical composition of bufadienolides isolated from the venom of Bufo viridis green toad occurring in Central Asia was determined and their biological properties were studied. Six individual bufadienolides were isolated by reverse-phase chromatography on a Lichrosorb RP-8 (10 µ) column in amounts sufficient for qualitative analysis. Two of these were previously identified as arenobufagin and gamabufotalin by NMR spectroscopy and x-ray diffraction methods. The chemical structures of four other bufadienolides are now established by NMR spectroscopy and HPLC. These compounds have been identified as telocinobufagin (3β,5β,14β-trihydroxybufa-20,22-dienolide), marinobufagin (3β, 5β-hydroxy-14,15β-epoxybufa-20,22-dienolide), bufarenogin (3β,12β,14β-hydroxybufa-20,22-dienolide), and bufalin (3β,14β-hydroxybufa-20,22-dienolide).
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11
Total citations:
11
Citations from 2024:
3
(27%)
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GOST
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Soliev A. B. et al. Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom // Pharmaceutical Chemistry Journal. 2007. Vol. 41. No. 11. pp. 600-604.
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Soliev A. B., Mirzaakhmedov S., Tashmukhamedov M. S., Kamaev F. G., Salikhov S. I., Zakirova N. I., Abramov A. Yu., Usanova I. V., Syrov V. N., Khushbaktova Z. A. Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom // Pharmaceutical Chemistry Journal. 2007. Vol. 41. No. 11. pp. 600-604.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1007/s11094-008-0024-y
UR - https://doi.org/10.1007/s11094-008-0024-y
TI - Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom
T2 - Pharmaceutical Chemistry Journal
AU - Soliev, A B
AU - Mirzaakhmedov, Sh.Ya.
AU - Tashmukhamedov, M S
AU - Kamaev, F G
AU - Salikhov, Sh I
AU - Zakirova, N I
AU - Abramov, A Yu
AU - Usanova, I V
AU - Syrov, V. N.
AU - Khushbaktova, Z. A.
PY - 2007
DA - 2007/11/01
PB - Springer Nature
SP - 600-604
IS - 11
VL - 41
SN - 0091-150X
SN - 1573-9031
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2007_Soliev,
author = {A B Soliev and Sh.Ya. Mirzaakhmedov and M S Tashmukhamedov and F G Kamaev and Sh I Salikhov and N I Zakirova and A Yu Abramov and I V Usanova and V. N. Syrov and Z. A. Khushbaktova},
title = {Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom},
journal = {Pharmaceutical Chemistry Journal},
year = {2007},
volume = {41},
publisher = {Springer Nature},
month = {nov},
url = {https://doi.org/10.1007/s11094-008-0024-y},
number = {11},
pages = {600--604},
doi = {10.1007/s11094-008-0024-y}
}
Cite this
MLA
Copy
Soliev, A. B., et al. “Chemical composition and biological activity of total bufadienolides from the Central-Asian Bufo viridis toad venom.” Pharmaceutical Chemistry Journal, vol. 41, no. 11, Nov. 2007, pp. 600-604. https://doi.org/10.1007/s11094-008-0024-y.