Analytical and Bioanalytical Chemistry, volume 398, issue 1, pages 181-191
Fluorescent cell-based sensing approaches for toxicity testing
Publication type: Journal Article
Publication date: 2010-04-01
Quartile SCImago
Q2
Quartile WOS
Q1
Impact factor: 4.3
ISSN: 16182642, 16182650
Biochemistry
Analytical Chemistry
Abstract
Fluorimetric cell-based sensing methods have attracted increasing interest in toxicity testing of pharmaceuticals, pathogens, environmental pollutants, and other chemicals. The objective of this review is to summarise the variety of approaches reported up to now and to present recent developments in this area. The different approaches are described in relation to their underlying mechanism and, especially, to the role of the fluorophore involved. The methods discussed include the use of fluorescent or fluorogenic indicators, fluorescence-based testing for membrane integrity, approaches based on fluorescence labelling, inducible fluorescent protein expression, and analysis of cellular autofluorescence. Several of these approaches have been shown to be advantageous in comparison with non-fluorescence methods and have potential in high-throughput screening, for example in drug discovery and safety pharmacology.
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1 publication, 2.7%
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1 publication, 2.7%
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1 publication, 2.7%
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Citations by publishers
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9
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Springer Nature
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Wiley
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Elsevier
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SAGE
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1 publication, 2.7%
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IOP Publishing
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IOP Publishing
1 publication, 2.7%
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Public Library of Science (PLoS)
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1 publication, 2.7%
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Pleiades Publishing
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1 publication, 2.7%
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Taylor & Francis
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1 publication, 2.7%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Fritzsche M., Mandenius C. Fluorescent cell-based sensing approaches for toxicity testing // Analytical and Bioanalytical Chemistry. 2010. Vol. 398. No. 1. pp. 181-191.
GOST all authors (up to 50)
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Fritzsche M., Mandenius C. Fluorescent cell-based sensing approaches for toxicity testing // Analytical and Bioanalytical Chemistry. 2010. Vol. 398. No. 1. pp. 181-191.
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TY - JOUR
DO - 10.1007/s00216-010-3651-6
UR - https://doi.org/10.1007%2Fs00216-010-3651-6
TI - Fluorescent cell-based sensing approaches for toxicity testing
T2 - Analytical and Bioanalytical Chemistry
AU - Fritzsche, Michael
AU - Mandenius, Carl-Fredrik
PY - 2010
DA - 2010/04/01 00:00:00
PB - Springer Nature
SP - 181-191
IS - 1
VL - 398
SN - 1618-2642
SN - 1618-2650
ER -
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@article{2010_Fritzsche,
author = {Michael Fritzsche and Carl-Fredrik Mandenius},
title = {Fluorescent cell-based sensing approaches for toxicity testing},
journal = {Analytical and Bioanalytical Chemistry},
year = {2010},
volume = {398},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs00216-010-3651-6},
number = {1},
pages = {181--191},
doi = {10.1007/s00216-010-3651-6}
}
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MLA
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Fritzsche, Michael, and Carl-Fredrik Mandenius. “Fluorescent cell-based sensing approaches for toxicity testing.” Analytical and Bioanalytical Chemistry, vol. 398, no. 1, Apr. 2010, pp. 181-191. https://doi.org/10.1007%2Fs00216-010-3651-6.