Current Genetics, volume 65, issue 1, pages 109-118

Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance

Mersaoui Sofiane Y 1
Wellinger Raymund J. 1
1
 
Department of Microbiology and Infectious Diseases, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canada
Publication typeJournal Article
Publication date2018-07-31
Journal: Current Genetics
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor2.5
ISSN01728083, 14320983
General Medicine
Genetics
Abstract
Chromosome stability relies on an adequate length and complete replication of telomeres, the physical ends of chromosomes. Telomeres are composed of short direct repeat DNA and the associated nucleoprotein complex is essential for providing end-stability. In addition, the so-called end-replication problem of the conventional replication requires that telomeres be elongated by a special mechanism which, in virtually all organisms, is based by a reverse transcriptase, called telomerase. Although, at the conceptual level, telomere functions are highly similar in most organisms, the telomeric nucleoprotein composition appears to diverge significantly, in particular if it is compared between mammalian and budding yeast cells. However, over the last years, the CST complex has emerged as a central hub for telomere replication in most systems. Composed of three proteins, it is related to the highly conserved replication protein A complex, and in all systems studied, it coordinates telomerase-based telomere elongation with lagging-strand DNA synthesis. In budding yeast, the Cdc13 protein of this complex also is essential for telomerase recruitment and this specialisation is accompanied by additional regulatory adaptations. Based on recent results obtained in yeast, here, we review these issues and present an updated telomere replication hypothesis. We speculate that the similarities between systems far outweigh the differences, once we detach ourselves from the historic descriptions of the mechanisms in the various organisms.

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Mersaoui S. Y., Wellinger R. J. Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance // Current Genetics. 2018. Vol. 65. No. 1. pp. 109-118.
GOST all authors (up to 50) Copy
Mersaoui S. Y., Wellinger R. J. Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance // Current Genetics. 2018. Vol. 65. No. 1. pp. 109-118.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s00294-018-0871-3
UR - https://doi.org/10.1007%2Fs00294-018-0871-3
TI - Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance
T2 - Current Genetics
AU - Mersaoui, Sofiane Y
AU - Wellinger, Raymund J.
PY - 2018
DA - 2018/07/31 00:00:00
PB - Springer Nature
SP - 109-118
IS - 1
VL - 65
SN - 0172-8083
SN - 1432-0983
ER -
BibTex |
Cite this
BibTex Copy
@article{2018_Mersaoui
author = {Sofiane Y Mersaoui and Raymund J. Wellinger},
title = {Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance},
journal = {Current Genetics},
year = {2018},
volume = {65},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007%2Fs00294-018-0871-3},
number = {1},
pages = {109--118},
doi = {10.1007/s00294-018-0871-3}
}
MLA
Cite this
MLA Copy
Mersaoui, Sofiane Y., and Raymund J. Wellinger. “Fine tuning the level of the Cdc13 telomere-capping protein for maximal chromosome stability performance.” Current Genetics, vol. 65, no. 1, Jul. 2018, pp. 109-118. https://doi.org/10.1007%2Fs00294-018-0871-3.
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