International Journal of Clinical Oncology, volume 26, issue 1, pages 18-25

Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy

Fukuhara Hideo 1
Yamamoto Shinkuro 1
Karashima Takashi 1
Inoue Keiji 1
1
 
Department of Urology, Kochi Medical School, Nankoku, Japan
Publication typeJournal Article
Publication date2020-05-26
Quartile SCImago
Q1
Quartile WOS
Q3
Impact factor3.3
ISSN13419625, 14377772
Oncology
General Medicine
Surgery
Hematology
Abstract
Photodynamic technology using light-sensitive and fluorescent substances has an important role in an accurate diagnosis for a variety of malignancies, including bladder cancer and prostate cancer. Light-sensitive and fluorescent substances accumulate specifically in tumor cells compared to normal tissue, and by light irradiation and excitation at each specific wavelength, tumor lesion, blood flow, lymph node and so on show fluorescence. 5-Aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) into mitochondria. PpIX is excited by blue light, red fluorescence is emitted in the mitochondria. This phenomenon is the mechanism of ALA-mediated photodynamic diagnosis (ALA-PDD). ALA-PDD has made it possible to visualize smaller lesions and flat lesions that were previously difficult to visualize by endoscope using a white-light source. So accurate diagnosis and complete resection become possible during operation. The accumulation of PpIX in the mitochondria also induces direct mitochondrial damage and subsequent cell death by red and green light. This biological reaction is the ALA-mediate photodynamic therapy (ALA-PDT). ALA-PDT has been developed as a modality for minimum invasive cancer treatment that utilizes low-energy light and photosensitizer. Vascular-activated photosensitizer induces rapid tumor ablation by PDT involving direct tumor cell killing as well as damage to the exposed microvasculature. We summarize the clinical outcomes of PDD and PDT for urothelial carcinoma and prostate cancer.

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GOST Copy
Fukuhara H. et al. Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy // International Journal of Clinical Oncology. 2020. Vol. 26. No. 1. pp. 18-25.
GOST all authors (up to 50) Copy
Fukuhara H., Yamamoto S., Karashima T., Inoue K. Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy // International Journal of Clinical Oncology. 2020. Vol. 26. No. 1. pp. 18-25.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s10147-020-01704-y
UR - https://doi.org/10.1007%2Fs10147-020-01704-y
TI - Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy
T2 - International Journal of Clinical Oncology
AU - Fukuhara, Hideo
AU - Yamamoto, Shinkuro
AU - Karashima, Takashi
AU - Inoue, Keiji
PY - 2020
DA - 2020/05/26 00:00:00
PB - Springer Nature
SP - 18-25
IS - 1
VL - 26
SN - 1341-9625
SN - 1437-7772
ER -
BibTex |
Cite this
BibTex Copy
@article{2020_Fukuhara
author = {Hideo Fukuhara and Shinkuro Yamamoto and Takashi Karashima and Keiji Inoue},
title = {Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy},
journal = {International Journal of Clinical Oncology},
year = {2020},
volume = {26},
publisher = {Springer Nature},
month = {may},
url = {https://doi.org/10.1007%2Fs10147-020-01704-y},
number = {1},
pages = {18--25},
doi = {10.1007/s10147-020-01704-y}
}
MLA
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MLA Copy
Fukuhara, Hideo, et al. “Photodynamic diagnosis and therapy for urothelial carcinoma and prostate cancer: new imaging technology and therapy.” International Journal of Clinical Oncology, vol. 26, no. 1, May. 2020, pp. 18-25. https://doi.org/10.1007%2Fs10147-020-01704-y.
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