BioMetals, volume 29, issue 3, pages 365-376
Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms
1
MedInsight Research Institute, Baltimore, USA
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Publication type: Journal Article
Publication date: 2016-04-06
PubMed ID:
27053146
Metals and Alloys
General Biochemistry, Genetics and Molecular Biology
Biomaterials
General Agricultural and Biological Sciences
Abstract
Gadolinium chelates are widely used as contrast media for magnetic resonance imaging. The approved gadolinium-based contrast agents (GBCAs) have historically been considered safe and well tolerated when used at recommended dosing levels. However, for nearly a decade, an association between GBCA administration and the development of nephrogenic systemic fibrosis (NSF) has been recognized in patients with severe renal impairment. This has led to modifications in clinical practices aimed at reducing the potential and incidence of NSF development. Newer reports have emerged regarding the accumulation of gadolinium in various tissues of patients who do not have renal impairment, including bone, brain, and kidneys. Despite the observations of gadolinium accumulation in tissues regardless of renal function, very limited clinical data regarding the potential for and mechanisms of toxicity is available. This significant gap in knowledge warrants retrospective cohort study efforts, as well as prospective studies that involve gadolinium ion (Gd3+) testing in patients exposed to GBCA. This review examines the potential biochemical and molecular basis of gadolinium toxicity, possible clinical significance of gadolinium tissue retention and accumulation, and methods that can limit gadolinium body burden.
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Rogosnitzky M., Branch S. Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms // BioMetals. 2016. Vol. 29. No. 3. pp. 365-376.
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Rogosnitzky M., Branch S. Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms // BioMetals. 2016. Vol. 29. No. 3. pp. 365-376.
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TY - JOUR
DO - 10.1007/s10534-016-9931-7
UR - https://doi.org/10.1007%2Fs10534-016-9931-7
TI - Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms
T2 - BioMetals
AU - Rogosnitzky, Moshe
AU - Branch, Stacy
PY - 2016
DA - 2016/04/06 00:00:00
PB - Springer Nature
SP - 365-376
IS - 3
VL - 29
PMID - 27053146
SN - 0966-0844
SN - 1572-8773
ER -
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@article{2016_Rogosnitzky
author = {Moshe Rogosnitzky and Stacy Branch},
title = {Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms},
journal = {BioMetals},
year = {2016},
volume = {29},
publisher = {Springer Nature},
month = {apr},
url = {https://doi.org/10.1007%2Fs10534-016-9931-7},
number = {3},
pages = {365--376},
doi = {10.1007/s10534-016-9931-7}
}
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MLA
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Rogosnitzky, Moshe, et al. “Gadolinium-based contrast agent toxicity: a review of known and proposed mechanisms.” BioMetals, vol. 29, no. 3, Apr. 2016, pp. 365-376. https://doi.org/10.1007%2Fs10534-016-9931-7.