Chemistry of Natural Compounds, volume 56, issue 5, pages 892-895
Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines
Publication type: Journal Article
Publication date: 2020-09-12
Journal:
Chemistry of Natural Compounds
Quartile SCImago
Q3
Quartile WOS
Q4
Impact factor: 0.8
ISSN: 00093130, 15738388
General Chemistry
General Biochemistry, Genetics and Molecular Biology
Plant Science
Abstract
Cytotoxicities of the quinolizidine alkaloid (–)-cytisine and 19 of its derivatives with substituents in the 3-, 9-, and 11-positions were assessed against A431 (epidermal carcinoma), A375 (melanoma), and HCT 116 (colorectal carcinoma) tumor cell lines using the MTT assay (etoposide reference drug). Practically all synthesized compounds at a concentration of 30 μM possessed slight ability to inhibit metabolic activity of these cell lines except benzylcytisine 4, methylcytisines 18 and 19, which contained a phenylurea fragment in the 9- or 11-position of the 2-pyridone core, and 11-chloro adamantylthiocarboxamide 16. Thiocarboxamide 16 reduced A431 cell survival up to 56.06% under the experimental conditions; derivatives 4, 18, and 19, of HCT 116 cell line by 57.52, 58.84, and 56.34%, respectively.
Citations by journals
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1
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Bioorganic and Medicinal Chemistry Letters
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Bioorganic and Medicinal Chemistry Letters
1 publication, 50%
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Chemistry of Natural Compounds
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Chemistry of Natural Compounds
1 publication, 50%
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1
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Citations by publishers
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Elsevier
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Elsevier
1 publication, 50%
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Springer Nature
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Springer Nature
1 publication, 50%
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1
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Petrova P. R. et al. Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines // Chemistry of Natural Compounds. 2020. Vol. 56. No. 5. pp. 892-895.
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Petrova P. R., Koval′skaya A. V., Tsypysheva I. P., Bunev A. S. Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines // Chemistry of Natural Compounds. 2020. Vol. 56. No. 5. pp. 892-895.
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TY - JOUR
DO - 10.1007/s10600-020-03177-x
UR - https://doi.org/10.1007%2Fs10600-020-03177-x
TI - Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines
T2 - Chemistry of Natural Compounds
AU - Petrova, P R
AU - Koval′skaya, A V
AU - Bunev, A S
AU - Tsypysheva, I P
PY - 2020
DA - 2020/09/12 00:00:00
PB - Springer Nature
SP - 892-895
IS - 5
VL - 56
SN - 0009-3130
SN - 1573-8388
ER -
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@article{2020_Petrova,
author = {P R Petrova and A V Koval′skaya and A S Bunev and I P Tsypysheva},
title = {Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines},
journal = {Chemistry of Natural Compounds},
year = {2020},
volume = {56},
publisher = {Springer Nature},
month = {sep},
url = {https://doi.org/10.1007%2Fs10600-020-03177-x},
number = {5},
pages = {892--895},
doi = {10.1007/s10600-020-03177-x}
}
Cite this
MLA
Copy
Petrova, P. R., et al. “Synthesis of Several Cytisine Derivatives and their Cytotoxicities against A431, A375, and HCT 116 Tumor Cell Lines.” Chemistry of Natural Compounds, vol. 56, no. 5, Sep. 2020, pp. 892-895. https://doi.org/10.1007%2Fs10600-020-03177-x.
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