Open Access
Indian Journal of Microbiology, volume 57, issue 4, pages 371-377
Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis
Publication type: Journal Article
Publication date: 2017-10-24
Journal:
Indian Journal of Microbiology
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor: 3
ISSN: 00468991, 09737715
PubMed ID:
29151636
Microbiology
Abstract
Tuberculosis (TB) is a deadly bacterial infectious disease caused by intra-cellular pathogen Mycobacterium tuberculosis (Mtb). There were an estimated 1.4 million TB deaths in 2015 and an additional 0.4 million deaths resulting from TB among individuals with HIV. Drug-discovery for its cure is very slow in comparison with the causative organism’s fast pace of mutations conferring drug resistance. Moreover, the field of drug-discovery of anti-TB drugs is constantly being challenged by the drug resistant strains of Mtb. Several molecules/inhibitors are being tested across the pharmaceutical industry and research centres for their suitability as drug candidate. It takes immense effort, high costs and a whole lot of screening to bring a single molecule to the clinics for patient cure. In last 60 years, hundreds of molecules have been patented for their probable use to develop drug for treatment of TB. However, only one drug has been successfully approved that is bedaquiline (1-(6-bromo-2 -methoxy-quinolin-3-yl)-4-dimethylamino-2-naphtalen-1-yl-1-phenyl-butan-2-ol). This is a brief review about bedaquiline (BDQ), the only drug in last 45 years approved for curing drug-resistant pulmonary TB, its development, action mechanism and development of resistance against it.
Citations by journals
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2
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Indian Journal of Microbiology
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Indian Journal of Microbiology
2 publications, 16.67%
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Molecular Diversity
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Molecular Diversity
1 publication, 8.33%
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Microbial genomics
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Microbial genomics
1 publication, 8.33%
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Frontiers in Pharmacology
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Frontiers in Pharmacology
1 publication, 8.33%
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Indian Journal of Tuberculosis
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Indian Journal of Tuberculosis, 1, 8.33%
Indian Journal of Tuberculosis
1 publication, 8.33%
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Journal of Proteomics
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Journal of Proteomics
1 publication, 8.33%
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WIREs Mechanisms of Disease
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WIREs Mechanisms of Disease
1 publication, 8.33%
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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
1 publication, 8.33%
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Postgraduate Medical Journal
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Postgraduate Medical Journal
1 publication, 8.33%
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Journal of Natural Products
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Journal of Natural Products
1 publication, 8.33%
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1
2
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Citations by publishers
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1
2
3
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Springer Nature
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Springer Nature
3 publications, 25%
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Microbiology Society
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Microbiology Society
1 publication, 8.33%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 8.33%
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Tuberculosis Association of India
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Tuberculosis Association of India, 1, 8.33%
Tuberculosis Association of India
1 publication, 8.33%
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Elsevier
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Elsevier
1 publication, 8.33%
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Wiley
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Wiley
1 publication, 8.33%
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American Society for Microbiology
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American Society for Microbiology
1 publication, 8.33%
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Oxford University Press
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Oxford University Press
1 publication, 8.33%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 8.33%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Singh P., Kumari R., Lal R. Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis // Indian Journal of Microbiology. 2017. Vol. 57. No. 4. pp. 371-377.
GOST all authors (up to 50)
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Singh P., Kumari R., Lal R. Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis // Indian Journal of Microbiology. 2017. Vol. 57. No. 4. pp. 371-377.
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TY - JOUR
DO - 10.1007/s12088-017-0674-0
UR - https://doi.org/10.1007%2Fs12088-017-0674-0
TI - Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis
T2 - Indian Journal of Microbiology
AU - Singh, Priya
AU - Kumari, Rashmi
AU - Lal, Rup
PY - 2017
DA - 2017/10/24 00:00:00
PB - Springer Nature
SP - 371-377
IS - 4
VL - 57
PMID - 29151636
SN - 0046-8991
SN - 0973-7715
ER -
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@article{2017_Singh,
author = {Priya Singh and Rashmi Kumari and Rup Lal},
title = {Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis},
journal = {Indian Journal of Microbiology},
year = {2017},
volume = {57},
publisher = {Springer Nature},
month = {oct},
url = {https://doi.org/10.1007%2Fs12088-017-0674-0},
number = {4},
pages = {371--377},
doi = {10.1007/s12088-017-0674-0}
}
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MLA
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Singh, Priya, et al. “Bedaquiline: Fallible Hope Against Drug Resistant Tuberculosis.” Indian Journal of Microbiology, vol. 57, no. 4, Oct. 2017, pp. 371-377. https://doi.org/10.1007%2Fs12088-017-0674-0.