BioNanoScience, volume 7, issue 4, pages 600-607

Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes

Nikitina Liliya E 1
Kiselev Sergei V 1
Bodrov Andrei V 1
Startseva Valeriya A 1
Artemova Nadezhda P 1
Klochkov Vladimir V 2
Galiullina Leisan F 2
Aganova Oksana V 2
Khaliullina Aliya V 1, 2
Lodochnikova Olga A 3
Azizova Zulfiya R 1
Rakhmatullina Adel A 1, 4
Publication typeJournal Article
Publication date2017-07-19
Journal: BioNanoScience
Quartile SCImago
Q3
Quartile WOS
Impact factor2.9
ISSN21911630, 21911649
Bioengineering
Biomedical Engineering
Abstract
It was shown that the synthesized camphene sulfone, in contrast to acetylsalicylic acid and clopidogrel, completely inhibits the activation of platelets induced by adrenaline and arachidonic acid, and reduces the influence of ADP, collagen, and ristocetin. Detailed NMR studies and molecular dynamics simulations using model SDS membranes indicated that the sulfone is embedded by its bicyclic part inside the SDS micelle, whereas -SO2(CH2)2OH fragment of sulfone is located on the outer part of the micelle and accessible for solvent. It was ascertained that hemocoagulant activity of sulfone is caused by its capability of inhibition of platelet activation and suppression of catalytic activity of phospholipid surface participating in formation of coagulation complexes of clotting factors.

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Nikitina L. E. et al. Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes // BioNanoScience. 2017. Vol. 7. No. 4. pp. 600-607.
GOST all authors (up to 50) Copy
Nikitina L. E., Kiselev S. V., Bodrov A. V., Startseva V. A., Artemova N. P., Klochkov V. V., Galiullina L. F., Aganova O. V., Khaliullina A. V., Lodochnikova O. A., Azizova Z. R., Rakhmatullina A. A. Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes // BioNanoScience. 2017. Vol. 7. No. 4. pp. 600-607.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1007/s12668-017-0432-0
UR - https://doi.org/10.1007%2Fs12668-017-0432-0
TI - Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes
T2 - BioNanoScience
AU - Nikitina, Liliya E
AU - Kiselev, Sergei V
AU - Bodrov, Andrei V
AU - Startseva, Valeriya A
AU - Artemova, Nadezhda P
AU - Klochkov, Vladimir V
AU - Galiullina, Leisan F
AU - Aganova, Oksana V
AU - Khaliullina, Aliya V
AU - Lodochnikova, Olga A
AU - Azizova, Zulfiya R
AU - Rakhmatullina, Adel A
PY - 2017
DA - 2017/07/19 00:00:00
PB - Springer Nature
SP - 600-607
IS - 4
VL - 7
SN - 2191-1630
SN - 2191-1649
ER -
BibTex |
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BibTex Copy
@article{2017_Nikitina,
author = {Liliya E Nikitina and Sergei V Kiselev and Andrei V Bodrov and Valeriya A Startseva and Nadezhda P Artemova and Vladimir V Klochkov and Leisan F Galiullina and Oksana V Aganova and Aliya V Khaliullina and Olga A Lodochnikova and Zulfiya R Azizova and Adel A Rakhmatullina},
title = {Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes},
journal = {BioNanoScience},
year = {2017},
volume = {7},
publisher = {Springer Nature},
month = {jul},
url = {https://doi.org/10.1007%2Fs12668-017-0432-0},
number = {4},
pages = {600--607},
doi = {10.1007/s12668-017-0432-0}
}
MLA
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MLA Copy
Nikitina, Liliya E., et al. “Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes.” BioNanoScience, vol. 7, no. 4, Jul. 2017, pp. 600-607. https://doi.org/10.1007%2Fs12668-017-0432-0.
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