Open Access
Protein and Cell, volume 5, issue 3, pages 194-202
Telomere regulation in pluripotent stem cells
Publication type: Journal Article
Publication date: 2014-02-22
Journal:
Protein and Cell
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 21.1
ISSN: 1674800X, 16748018
PubMed ID:
24563217
Drug Discovery
Biochemistry
Cell Biology
Biotechnology
Abstract
Pluripotent stem cells (PSCs) have the potential to produce any types of cells from all three basic germ layers and the capacity to self-renew and proliferate indefinitely in vitro. The two main types of PSCs, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), share common features such as colony morphology, high expression of Oct4 and Nanog, and strong alkaline phosphatase activity. In recent years, increasing evidences suggest that telomere length represents another important internal factor in maintaining stem cell pluripotency. Telomere length homeostasis and its structural integrity help to protect chromosome ends from recombination, end fusion, and DNA damage responses, ensuring the divisional ability of mammalian cells. PSCs generally exhibit high telomerase activity to maintain their extremely long and stable telomeres, and emerging data indicate the alternative lengthening of telomeres (ALT) pathway may play an important role in telomere functions too. Such characteristics are likely key to their abilities to differentiate into diverse cell types in vivo. In this review, we will focus on the function and regulation of telomeres in ESCs and iPSCs, thereby shedding light on the importance of telomere length to pluripotency and the mechanisms that regulate telomeres in PSCs.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Huang Y. et al. Telomere regulation in pluripotent stem cells // Protein and Cell. 2014. Vol. 5. No. 3. pp. 194-202.
GOST all authors (up to 50)
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Huang Y., Liang P., Liu D., Huang J., Zhou S. Telomere regulation in pluripotent stem cells // Protein and Cell. 2014. Vol. 5. No. 3. pp. 194-202.
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TY - JOUR
DO - 10.1007/s13238-014-0028-1
UR - https://doi.org/10.1007%2Fs13238-014-0028-1
TI - Telomere regulation in pluripotent stem cells
T2 - Protein and Cell
AU - Liang, Puping
AU - Huang, Junjiu
AU - Zhou, Songyang
AU - Huang, Yan
AU - Liu, Dan
PY - 2014
DA - 2014/02/22 00:00:00
PB - Springer Nature
SP - 194-202
IS - 3
VL - 5
PMID - 24563217
SN - 1674-800X
SN - 1674-8018
ER -
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@article{2014_Huang,
author = {Puping Liang and Junjiu Huang and Songyang Zhou and Yan Huang and Dan Liu},
title = {Telomere regulation in pluripotent stem cells},
journal = {Protein and Cell},
year = {2014},
volume = {5},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007%2Fs13238-014-0028-1},
number = {3},
pages = {194--202},
doi = {10.1007/s13238-014-0028-1}
}
Cite this
MLA
Copy
Huang, Yan, et al. “Telomere regulation in pluripotent stem cells.” Protein and Cell, vol. 5, no. 3, Feb. 2014, pp. 194-202. https://doi.org/10.1007%2Fs13238-014-0028-1.