Open Access
Open access
Protein and Cell, volume 10, issue 9, pages 631-648

Mitochondrion-processed TERC regulates senescence without affecting telomerase activities

Publication typeJournal Article
Publication date2019-02-20
Journal: Protein and Cell
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor21.1
ISSN1674800X, 16748018
Drug Discovery
Biochemistry
Cell Biology
Biotechnology
Abstract
Mitochondrial dysfunctions play major roles in ageing. How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc−/− cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals.

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GOST |
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GOST Copy
Zheng Q. et al. Mitochondrion-processed TERC regulates senescence without affecting telomerase activities // Protein and Cell. 2019. Vol. 10. No. 9. pp. 631-648.
GOST all authors (up to 50) Copy
Zheng Q., Liu P., Gao G., Yuan J., Wang P., Huang J., Xie L., Lu X., Di F., Tong T., Chen J., Lü Z., Guan J., Wang G. Mitochondrion-processed TERC regulates senescence without affecting telomerase activities // Protein and Cell. 2019. Vol. 10. No. 9. pp. 631-648.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1007/s13238-019-0612-5
UR - https://doi.org/10.1007%2Fs13238-019-0612-5
TI - Mitochondrion-processed TERC regulates senescence without affecting telomerase activities
T2 - Protein and Cell
AU - Zheng, Qian
AU - Liu, Peipei
AU - Gao, Ge
AU - Yuan, Jiapei
AU - Wang, Pengfeng
AU - Huang, Jinliang
AU - Xie, Leiming
AU - Lu, Xinping
AU - Di, Fan
AU - Tong, Tanjun
AU - Chen, Jun
AU - Lü, Zhi
AU - Guan, Jisong
AU - Wang, Geng
PY - 2019
DA - 2019/02/20 00:00:00
PB - Springer Nature
SP - 631-648
IS - 9
VL - 10
PMID - 30788732
SN - 1674-800X
SN - 1674-8018
ER -
BibTex |
Cite this
BibTex Copy
@article{2019_Zheng
author = {Qian Zheng and Peipei Liu and Ge Gao and Jiapei Yuan and Pengfeng Wang and Jinliang Huang and Leiming Xie and Xinping Lu and Fan Di and Tanjun Tong and Jun Chen and Zhi Lü and Jisong Guan and Geng Wang},
title = {Mitochondrion-processed TERC regulates senescence without affecting telomerase activities},
journal = {Protein and Cell},
year = {2019},
volume = {10},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007%2Fs13238-019-0612-5},
number = {9},
pages = {631--648},
doi = {10.1007/s13238-019-0612-5}
}
MLA
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MLA Copy
Zheng, Qian, et al. “Mitochondrion-processed TERC regulates senescence without affecting telomerase activities.” Protein and Cell, vol. 10, no. 9, Feb. 2019, pp. 631-648. https://doi.org/10.1007%2Fs13238-019-0612-5.
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