Open Access
Protein and Cell, volume 10, issue 9, pages 631-648
Mitochondrion-processed TERC regulates senescence without affecting telomerase activities
Zheng Qian
1
,
Liu Peipei
1
,
Gao Ge
1
,
Yuan Jiapei
1
,
Wang Pengfeng
2
,
Huang Jinliang
1
,
Xie Leiming
1
,
Lu Xinping
1
,
Di Fan
1
,
Tong Tanjun
2, 3
,
Chen Jun
2, 3
,
Lü Zhi
1
,
Guan Jisong
1
,
Wang Geng
1
Publication type: Journal Article
Publication date: 2019-02-20
Journal:
Protein and Cell
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 21.1
ISSN: 1674800X, 16748018
PubMed ID:
30788732
Drug Discovery
Biochemistry
Cell Biology
Biotechnology
Abstract
Mitochondrial dysfunctions play major roles in ageing. How mitochondrial stresses invoke downstream responses and how specificity of the signaling is achieved, however, remains unclear. We have previously discovered that the RNA component of Telomerase TERC is imported into mitochondria, processed to a shorter form TERC-53, and then exported back to the cytosol. Cytosolic TERC-53 levels respond to mitochondrial functions, but have no direct effect on these functions, suggesting that cytosolic TERC-53 functions downstream of mitochondria as a signal of mitochondrial functions. Here, we show that cytosolic TERC-53 plays a regulatory role on cellular senescence and is involved in cognition decline in 10 months old mice, independent of its telomerase function. Manipulation of cytosolic TERC-53 levels affects cellular senescence and cognition decline in 10 months old mouse hippocampi without affecting telomerase activity, and most importantly, affects cellular senescence in terc−/− cells. These findings uncover a senescence-related regulatory pathway with a non-coding RNA as the signal in mammals.
Citations by journals
1
2
3
|
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Biomedicines
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|
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1 publication, 3.03%
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Journal of Clinical Medicine
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1 publication, 3.03%
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1 publication, 3.03%
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1 publication, 3.03%
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1 publication, 3.03%
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|
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1 publication, 3.03%
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|
Cancer Letters
1 publication, 3.03%
|
BioEssays
|
BioEssays
1 publication, 3.03%
|
Journal of Extracellular Vesicles
|
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1 publication, 3.03%
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RNA Biology
|
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1 publication, 3.03%
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Pharmacological Research
|
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1 publication, 3.03%
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Nucleic Acids Research
|
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1 publication, 3.03%
|
Proceedings of the National Academy of Sciences of the United States of America
|
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1 publication, 3.03%
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Cellular and Molecular Biology Letters
|
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1 publication, 3.03%
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1
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3
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Citations by publishers
2
4
6
8
10
12
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Elsevier
|
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12 publications, 36.36%
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
9 publications, 27.27%
|
Frontiers Media S.A.
|
Frontiers Media S.A.
3 publications, 9.09%
|
Wiley
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Wiley
2 publications, 6.06%
|
The Royal Society
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The Royal Society
1 publication, 3.03%
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Taylor & Francis
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Taylor & Francis
1 publication, 3.03%
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Oxford University Press
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Oxford University Press
1 publication, 3.03%
|
Proceedings of the National Academy of Sciences (PNAS)
|
Proceedings of the National Academy of Sciences (PNAS)
1 publication, 3.03%
|
Springer Nature
|
Springer Nature
1 publication, 3.03%
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2
4
6
8
10
12
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Zheng Q. et al. Mitochondrion-processed TERC regulates senescence without affecting telomerase activities // Protein and Cell. 2019. Vol. 10. No. 9. pp. 631-648.
GOST all authors (up to 50)
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Zheng Q., Liu P., Gao G., Yuan J., Wang P., Huang J., Xie L., Lu X., Di F., Tong T., Chen J., Lü Z., Guan J., Wang G. Mitochondrion-processed TERC regulates senescence without affecting telomerase activities // Protein and Cell. 2019. Vol. 10. No. 9. pp. 631-648.
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TY - JOUR
DO - 10.1007/s13238-019-0612-5
UR - https://doi.org/10.1007%2Fs13238-019-0612-5
TI - Mitochondrion-processed TERC regulates senescence without affecting telomerase activities
T2 - Protein and Cell
AU - Zheng, Qian
AU - Liu, Peipei
AU - Gao, Ge
AU - Yuan, Jiapei
AU - Wang, Pengfeng
AU - Huang, Jinliang
AU - Xie, Leiming
AU - Lu, Xinping
AU - Di, Fan
AU - Tong, Tanjun
AU - Chen, Jun
AU - Lü, Zhi
AU - Guan, Jisong
AU - Wang, Geng
PY - 2019
DA - 2019/02/20 00:00:00
PB - Springer Nature
SP - 631-648
IS - 9
VL - 10
PMID - 30788732
SN - 1674-800X
SN - 1674-8018
ER -
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@article{2019_Zheng
author = {Qian Zheng and Peipei Liu and Ge Gao and Jiapei Yuan and Pengfeng Wang and Jinliang Huang and Leiming Xie and Xinping Lu and Fan Di and Tanjun Tong and Jun Chen and Zhi Lü and Jisong Guan and Geng Wang},
title = {Mitochondrion-processed TERC regulates senescence without affecting telomerase activities},
journal = {Protein and Cell},
year = {2019},
volume = {10},
publisher = {Springer Nature},
month = {feb},
url = {https://doi.org/10.1007%2Fs13238-019-0612-5},
number = {9},
pages = {631--648},
doi = {10.1007/s13238-019-0612-5}
}
Cite this
MLA
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Zheng, Qian, et al. “Mitochondrion-processed TERC regulates senescence without affecting telomerase activities.” Protein and Cell, vol. 10, no. 9, Feb. 2019, pp. 631-648. https://doi.org/10.1007%2Fs13238-019-0612-5.