Progress in Biomaterials, volume 8, issue 3, pages 155-168

Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles

Hiremath Chinmay G ¹

Heggnnavar Geetha B ²

Kariduraganavar Mahadevappa Y ²

Hiremath Murigendra B. ¹

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Department of Biotechnology and Microbiology, Karnatak University, Dharwad, India |

Department of Chemistry, Karnatak University, Dharwad, India |

Publication type: Journal Article

Publication date: 2019-06-13

Springer Nature

Journal: Progress in Biomaterials

Quartile SCImago

Quartile WOS

Impact factor: 4.9

ISSN: 21940509, 21940517

DOI: 10.1007/s40204-019-0118-5

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PubMed ID: 31197663

General Medicine

Abstract

Active targeting of folic acid and passive targeting of magnetic nanoparticles to bring about co-delivery of hydrophobic chemotherapeutic agents were the focus of this work. Co-precipitation in alkaline environment was employed for synthesizing Fe3O4 nanoparticles and stabilized by oleic acid. Aqueous dispersibility of oleic acid coated nanoparticles was brought about by folic acid modified Pluronic F127 and Pluronic F127 mixture. Folic acid is used as a targeting agent which was joined to Pluronic F127 via diethylene glycol bis(3-aminopropyl) ether spacer. The nanocomposite was used to delivery hydrophobic anticancer drugs, paclitaxel, and curcumin. Successful modification at each step was confirmed by FTIR and NMR. Quantitative analysis of attached folic acid indicated a total of 84.34% amount of conjugation. Nanoparticles characterization revealed the hydrodynamic size of and nanocomposite to be 94.2 nm nanometres. Furthermore, transmission electron micrograph reveals the size of the nanoparticle to be 12.5 nm hence also shows the superparamagnetic activity. Drug encapsulation efficiency of 34.7% and 59.5% was noted for paclitaxel and curcumin, respectively. Cytotoxic property of drug-loaded nanocomposites was increased in case of folic acid functionalized nanoparticles and further increased in the presence of an external magnetic field. Cellular uptake increased in the folic acid conjugated sample. Further many folds in the presence of an external magnetic field.Graphic abstract

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Citations by journals

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Nanomaterials	Nanomaterials, 1, 3.23% Nanomaterials 1 publication, 3.23%
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Journal of Nanobiotechnology	Journal of Nanobiotechnology, 1, 3.23% Journal of Nanobiotechnology 1 publication, 3.23%
Journal of Nanoparticle Research	Journal of Nanoparticle Research, 1, 3.23% Journal of Nanoparticle Research 1 publication, 3.23%
Journal of Solid State Electrochemistry	Journal of Solid State Electrochemistry, 1, 3.23% Journal of Solid State Electrochemistry 1 publication, 3.23%
Chemico-Biological Interactions	Chemico-Biological Interactions, 1, 3.23% Chemico-Biological Interactions 1 publication, 3.23%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 1, 3.23% Colloids and Surfaces B: Biointerfaces 1 publication, 3.23%
Biomedical Materials (Bristol)	Biomedical Materials (Bristol), 1, 3.23% Biomedical Materials (Bristol) 1 publication, 3.23%
Materials Today Bio	Materials Today Bio, 1, 3.23% Materials Today Bio 1 publication, 3.23%
Life Sciences	Life Sciences, 1, 3.23% Life Sciences 1 publication, 3.23%
Materials Science and Engineering C	Materials Science and Engineering C, 1, 3.23% Materials Science and Engineering C 1 publication, 3.23%
Colloids and Surfaces A: Physicochemical and Engineering Aspects	Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1, 3.23% Colloids and Surfaces A: Physicochemical and Engineering Aspects 1 publication, 3.23%
Journal of Controlled Release	Journal of Controlled Release, 1, 3.23% Journal of Controlled Release 1 publication, 3.23%
Macromolecular Chemistry and Physics	Macromolecular Chemistry and Physics, 1, 3.23% Macromolecular Chemistry and Physics 1 publication, 3.23%
RSC Advances	RSC Advances, 1, 3.23% RSC Advances 1 publication, 3.23%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 3.23% Journal of Materials Chemistry B 1 publication, 3.23%
Pharmaceutical Development and Technology	Pharmaceutical Development and Technology, 1, 3.23% Pharmaceutical Development and Technology 1 publication, 3.23%
Drug Delivery	Drug Delivery, 1, 3.23% Drug Delivery 1 publication, 3.23%
Particuology	Particuology, 1, 3.23% Particuology 1 publication, 3.23%
Drug Development Research	Drug Development Research, 1, 3.23% Drug Development Research 1 publication, 3.23%
Materials	Materials, 1, 3.23% Materials 1 publication, 3.23%
Biomedicine and Pharmacotherapy	Biomedicine and Pharmacotherapy, 1, 3.23% Biomedicine and Pharmacotherapy 1 publication, 3.23%
Nanomedicine and Nanotoxicology	Nanomedicine and Nanotoxicology, 1, 3.23% Nanomedicine and Nanotoxicology 1 publication, 3.23%
International Journal of Nanomedicine	International Journal of Nanomedicine, 1, 3.23% International Journal of Nanomedicine 1 publication, 3.23%
International Journal of Biological Macromolecules	International Journal of Biological Macromolecules, 1, 3.23% International Journal of Biological Macromolecules 1 publication, 3.23%
Journal of Drug Delivery Science and Technology	Journal of Drug Delivery Science and Technology, 1, 3.23% Journal of Drug Delivery Science and Technology 1 publication, 3.23%
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Citations by publishers

	2 4 6 8 10 12
Elsevier	Elsevier, 11, 35.48% Elsevier 11 publications, 35.48%
Springer Nature	Springer Nature, 5, 16.13% Springer Nature 5 publications, 16.13%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 12.9% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 12.9%
Frontiers Media S.A.	Frontiers Media S.A., 2, 6.45% Frontiers Media S.A. 2 publications, 6.45%
Wiley	Wiley, 2, 6.45% Wiley 2 publications, 6.45%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 6.45% Royal Society of Chemistry (RSC) 2 publications, 6.45%
Taylor & Francis	Taylor & Francis, 2, 6.45% Taylor & Francis 2 publications, 6.45%
IOP Publishing	IOP Publishing, 1, 3.23% IOP Publishing 1 publication, 3.23%
Dove Medical Press	Dove Medical Press, 1, 3.23% Dove Medical Press 1 publication, 3.23%
	2 4 6 8 10 12

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Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Hiremath C. G. et al. Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles // Progress in Biomaterials. 2019. Vol. 8. No. 3. pp. 155-168.

GOST all authors (up to 50) Copy

Hiremath C. G., Heggnnavar G. B., Kariduraganavar M. Y., Hiremath M. B. Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles // Progress in Biomaterials. 2019. Vol. 8. No. 3. pp. 155-168.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1007/s40204-019-0118-5

UR - https://doi.org/10.1007%2Fs40204-019-0118-5

TI - Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles

T2 - Progress in Biomaterials

AU - Hiremath, Chinmay G

AU - Heggnnavar, Geetha B

AU - Kariduraganavar, Mahadevappa Y

AU - Hiremath, Murigendra B.

PY - 2019

DA - 2019/06/13 00:00:00

PB - Springer Nature

SP - 155-168

IS - 3

VL - 8

PMID - 31197663

SN - 2194-0509

SN - 2194-0517

ER -

BibTex |

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BibTex Copy

@article{2019_Hiremath,

author = {Chinmay G Hiremath and Geetha B Heggnnavar and Mahadevappa Y Kariduraganavar and Murigendra B. Hiremath},

title = {Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles},

journal = {Progress in Biomaterials},

year = {2019},

volume = {8},

publisher = {Springer Nature},

month = {jun},

url = {https://doi.org/10.1007%2Fs40204-019-0118-5},

number = {3},

pages = {155--168},

doi = {10.1007/s40204-019-0118-5}

}

MLA

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MLA Copy

Hiremath, Chinmay G., et al. “Co-delivery of paclitaxel and curcumin to foliate positive cancer cells using Pluronic-coated iron oxide nanoparticles.” Progress in Biomaterials, vol. 8, no. 3, Jun. 2019, pp. 155-168. https://doi.org/10.1007%2Fs40204-019-0118-5.

Found error?

Publisher

Springer Nature

Journal

Progress in Biomaterials

Quartile SCImago

Quartile WOS

Impact factor

4.9

ISSN

21940509 (Print)
21940517 (Electronic)