The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography

Publication typeJournal Article
Publication date1977-07-01
SJR
CiteScore
Impact factor
ISSN00052760
Biochemistry
Biophysics
Endocrinology
Abstract
Phosphatidylserine has been prepared from phosphatidylcholine by a one-step transphosphatidylation catalyzed by phospholipase D in the presence of L-serine. The resulting mixture of phosphatidylserine and phosphatidic acid is easily and rapidly separated by CM-cellulose column chromatography using step=wise elution with solvents containing increasing percentages of methanol in chloroform. The over-all yield of the procedure is 40-50% depending on the scale of the preparation. CM-Cellulose column chromatography proved to be extremely useful in separating phospholipid mixtures obtained by phosphatidyltransferase reactions of phospholipase D and is also suitable for fractionation of other lipid extracts.
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GOST |
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GOST Copy
Comfurius P., Zwaal R. F. A. The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography // Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1977. Vol. 488. No. 1. pp. 36-42.
GOST all authors (up to 50) Copy
Comfurius P., Zwaal R. F. A. The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography // Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1977. Vol. 488. No. 1. pp. 36-42.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/0005-2760(77)90120-5
UR - https://doi.org/10.1016/0005-2760(77)90120-5
TI - The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography
T2 - Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
AU - Comfurius, P.
AU - Zwaal, R F A
PY - 1977
DA - 1977/07/01
PB - Elsevier
SP - 36-42
IS - 1
VL - 488
PMID - 560868
SN - 0005-2760
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{1977_Comfurius,
author = {P. Comfurius and R F A Zwaal},
title = {The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography},
journal = {Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism},
year = {1977},
volume = {488},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/0005-2760(77)90120-5},
number = {1},
pages = {36--42},
doi = {10.1016/0005-2760(77)90120-5}
}
MLA
Cite this
MLA Copy
Comfurius, P., and R F A Zwaal. “The enzymatic synthesis of phosphatidylserine and purification by CM-cellulose column chromatography.” Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, vol. 488, no. 1, Jul. 1977, pp. 36-42. https://doi.org/10.1016/0005-2760(77)90120-5.