Open Access

Chinese Herbal Medicines

, volume 10 , issue 1 , pages 73-79

Metabolite characterization of Penta- O -galloyl-β- D -glucose in rat biofluids by HPLC-QTOF-MS

Cui-xia Ma ¹

Xue Zhao ¹

Pei Wang ¹

Pu Jia ¹

Xin‐Feng Zhao ¹

Chao-Ni Xiao ¹

Xiaohui Zheng ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Key Laboratory of Resource Biology and Biotechnology in Western China,Ministry of Education,College of Life Sciences,Northwest University,Xi′an 710069,China) |

Publication type: Journal Article

Publication date: 2018-01-10

Elsevier

Chinese Herbal Medicines

scimago Q1

wos Q1

SJR: 0.900

CiteScore: 8.8

Impact factor: 8.9

ISSN: 16746384, 25893610

DOI: 10.1016/j.chmed.2018.01.002

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Pharmacology

Complementary and alternative medicine

Pharmacology (medical)

Abstract

Objective To understand the in vivo metabolic fate of 1,2,3,4,6-Penta-O-galloyl-β- d -glucose (PGG) naturally existed in many medicinal herbs and food plants such as Rhus chinensis, Paeonia suffruticosa, Paeonia lactiflora and Mango. Methods The metabolites of PGG in rat biofluids were characterized using high performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (HPLC-QTOF-MS). Results Ten metabolites in urine, five metabolites in feces and two metabolites in plasma, were observed when the rats were administrated with a single intravenous injection of PGG (20 mg/kg). Conclusion PGG is firstly metabolized to gallic acid, then gallic acid undergoes sulfation, glucuronidation and methylation by rat liver. The determination of metabolites and the proposed metabolic pathway of PGG in vivo will be benefit to gain deeper insights into its pharmacological activities.

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GOST |

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GOST Copy

Ma C. et al. Metabolite characterization of Penta- O -galloyl-β- D -glucose in rat biofluids by HPLC-QTOF-MS // Chinese Herbal Medicines. 2018. Vol. 10. No. 1. pp. 73-79.

GOST all authors (up to 50) Copy

Ma C., Zhao X., Wang P., Jia P., Zhao X., Xiao C., Zheng X. Metabolite characterization of Penta- O -galloyl-β- D -glucose in rat biofluids by HPLC-QTOF-MS // Chinese Herbal Medicines. 2018. Vol. 10. No. 1. pp. 73-79.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.chmed.2018.01.002

UR - https://doi.org/10.1016/j.chmed.2018.01.002

TI - Metabolite characterization of Penta- O -galloyl-β- D -glucose in rat biofluids by HPLC-QTOF-MS

T2 - Chinese Herbal Medicines

AU - Ma, Cui-xia

AU - Zhao, Xue

AU - Wang, Pei

AU - Jia, Pu

AU - Zhao, Xin‐Feng

AU - Xiao, Chao-Ni

AU - Zheng, Xiaohui

PY - 2018

DA - 2018/01/10

PB - Elsevier

SP - 73-79

IS - 1

VL - 10

SN - 1674-6384

SN - 2589-3610

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Ma,

author = {Cui-xia Ma and Xue Zhao and Pei Wang and Pu Jia and Xin‐Feng Zhao and Chao-Ni Xiao and Xiaohui Zheng},

title = {Metabolite characterization of Penta- O -galloyl-β- D -glucose in rat biofluids by HPLC-QTOF-MS},

journal = {Chinese Herbal Medicines},

year = {2018},

volume = {10},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/j.chmed.2018.01.002},

number = {1},

pages = {73--79},

doi = {10.1016/j.chmed.2018.01.002}

}

MLA

Cite this

MLA Copy

Ma, Cui-xia, et al. “Metabolite characterization of Penta- O -galloyl-β- D -glucose in rat biofluids by HPLC-QTOF-MS.” Chinese Herbal Medicines, vol. 10, no. 1, Jan. 2018, pp. 73-79. https://doi.org/10.1016/j.chmed.2018.01.002.

Publisher

Elsevier

Journal

Chinese Herbal Medicines

scimago Q1

wos Q1

SJR

0.900

CiteScore

8.8

Impact factor

8.9

ISSN

16746384 (Print)

25893610 (Electronic)