Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression
Xiaotao Hu
1, 2
,
Xianggang Hu
1, 2
,
Tong Chen
1, 2
,
Tong Chen
1, 2
,
Pu Guo
2, 3
,
Pengju Guo
2, 3
,
Qing Wang
1, 2
,
Aiwu Ding
2
,
Aoxue Ding
2
,
GUO-QING QIN
2
,
Wang Wen Qiong
2
,
Lijiang Xuan
1, 2, 3
Publication type: Journal Article
Publication date: 2024-06-01
scimago Q2
wos Q3
SJR: 0.537
CiteScore: 3.9
Impact factor: 2.6
ISSN: 0367326X, 18736971
PubMed ID:
38583637
Drug Discovery
General Medicine
Pharmacology
Abstract
Four undescribed amide alkaloids hongkongensines A-C and 1-(1-oxo-6-hydroxy-2E,4E-dodecadienyl)-piperidine, five known amide alkaloids, and three known neolignans were isolated from the aerial part of Piper hongkongense. The planar structures of these compounds were determined by detailed analyses of HR-ESI-MS and NMR data. The absolute configurations of hongkongensines A-C were elucidated by single-crystal X-ray diffraction analysis and ECD calculations. Moreover, the inhibitory activities of PCSK9 expression in vitro for all compounds were assessed by PCSK9 AlphaLISA screening. Kadsurenone (10) displayed a significant inhibitory activity at 5 μM with an inhibition rate of 51.98%, compared with 55.55% of berberine (BBR 5 μM).
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Hu X. et al. Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression // Fitoterapia. 2024. Vol. 175. p. 105951.
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Hu X., Hu X., Chen T., Chen T., Guo P., Guo P., Wang Q., Ding A., Ding A., QIN G., Wen Qiong W., Xuan L. Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression // Fitoterapia. 2024. Vol. 175. p. 105951.
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TY - JOUR
DO - 10.1016/j.fitote.2024.105951
UR - https://linkinghub.elsevier.com/retrieve/pii/S0367326X24001345
TI - Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression
T2 - Fitoterapia
AU - Hu, Xiaotao
AU - Hu, Xianggang
AU - Chen, Tong
AU - Chen, Tong
AU - Guo, Pu
AU - Guo, Pengju
AU - Wang, Qing
AU - Ding, Aiwu
AU - Ding, Aoxue
AU - QIN, GUO-QING
AU - Wen Qiong, Wang
AU - Xuan, Lijiang
PY - 2024
DA - 2024/06/01
PB - Elsevier
SP - 105951
VL - 175
PMID - 38583637
SN - 0367-326X
SN - 1873-6971
ER -
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@article{2024_Hu,
author = {Xiaotao Hu and Xianggang Hu and Tong Chen and Tong Chen and Pu Guo and Pengju Guo and Qing Wang and Aiwu Ding and Aoxue Ding and GUO-QING QIN and Wang Wen Qiong and Lijiang Xuan},
title = {Amide alkaloids and neolignans from Piper hongkongense and their inhibitory activities of PCSK9 expression},
journal = {Fitoterapia},
year = {2024},
volume = {175},
publisher = {Elsevier},
month = {jun},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0367326X24001345},
pages = {105951},
doi = {10.1016/j.fitote.2024.105951}
}