Open Access
Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition
Toru Imai
1
,
Yasuhiro Kosuge
1
,
Hiroaki Saito
2
,
Taketo Uchiyama
2
,
Taira Wada
3
,
Shigeki Shimba
3
,
Kumiko Ishige
1
,
Shinichi Miyairi
2
,
Makoto Makishima
4
,
Yoshihisa ITO
1
Publication type: Journal Article
Publication date: 2016-03-14
scimago Q2
wos Q2
SJR: 0.814
CiteScore: 6.2
Impact factor: 2.9
ISSN: 13478613, 13478648
PubMed ID:
27032909
Pharmacology
Molecular Medicine
Abstract
S-allyl-l-cysteine (SAC) is known to have neuroprotective properties. We synthesized various SAC derivatives and tested their effects on endoplasmic reticulum stress-induced neurotoxicity in cultured hippocampal neurons (HPNs). Among the compounds tested, S-propyl-l-cysteine (SPC) exhibited the strongest neuroprotective activity in HPNs, followed by S-ethyl-l-cysteine (SEC) and S-methyl-l-cysteine (SMC). Unlike SAC and SMC, SPC and SEC did not have inhibitory activity on μ-calpain, suggesting that the mechanism underlying the protective activity of SPC and SEC differs from that of SAC.
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Metrics
14
Total citations:
14
Citations from 2024:
2
(14%)
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GOST
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Imai T. et al. Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition // Journal of Pharmacological Sciences. 2016. Vol. 130. No. 3. pp. 185-188.
GOST all authors (up to 50)
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Imai T., Kosuge Y., Saito H., Uchiyama T., Wada T., Shimba S., Ishige K., Miyairi S., Makishima M., ITO Y. Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition // Journal of Pharmacological Sciences. 2016. Vol. 130. No. 3. pp. 185-188.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.jphs.2016.03.004
UR - https://doi.org/10.1016/j.jphs.2016.03.004
TI - Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition
T2 - Journal of Pharmacological Sciences
AU - Imai, Toru
AU - Kosuge, Yasuhiro
AU - Saito, Hiroaki
AU - Uchiyama, Taketo
AU - Wada, Taira
AU - Shimba, Shigeki
AU - Ishige, Kumiko
AU - Miyairi, Shinichi
AU - Makishima, Makoto
AU - ITO, Yoshihisa
PY - 2016
DA - 2016/03/14
PB - Elsevier
SP - 185-188
IS - 3
VL - 130
PMID - 27032909
SN - 1347-8613
SN - 1347-8648
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Imai,
author = {Toru Imai and Yasuhiro Kosuge and Hiroaki Saito and Taketo Uchiyama and Taira Wada and Shigeki Shimba and Kumiko Ishige and Shinichi Miyairi and Makoto Makishima and Yoshihisa ITO},
title = {Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition},
journal = {Journal of Pharmacological Sciences},
year = {2016},
volume = {130},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.jphs.2016.03.004},
number = {3},
pages = {185--188},
doi = {10.1016/j.jphs.2016.03.004}
}
Cite this
MLA
Copy
Imai, Toru, et al. “Neuroprotective effect of S-allyl-l-cysteine derivatives against endoplasmic reticulum stress-induced cytotoxicity is independent of calpain inhibition.” Journal of Pharmacological Sciences, vol. 130, no. 3, Mar. 2016, pp. 185-188. https://doi.org/10.1016/j.jphs.2016.03.004.