Phytochemistry

, volume 208 , pages 113609

Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity

Yu Fei Xi ^{1, 2, 3, 4}

Ming Bai ^{1, 2, 3, 4}

Xin Zhang ^{1, 2, 3, 4}

Zi Lin Hou ^{1, 2, 3, 4}

Bin Lin ⁵

Guo Dong Yao ^{1, 2, 3, 4}

Li-Li Lou ^{1, 2, 3, 4}

Xiaobo Wang ⁶

Shao-Jiang Song ^{1, 2, 3, 4}

Xiaoxiao Huang ^{1, 2, 3, 4}

Hide authors affiliations Show authors affiliations: 6 affiliations

Engineering Research Center of Natural Medicine Active Molecule Research & Development, Liaoning Province

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province

Key Laboratory of Natural Bioactive Compounds Discovery & Modification, Shenyang |

⁴

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China |

⁵

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China |

⁶

Chinese People's Liberation Army Logistics Support Force No. 967 Hospital, Dalian, 116021, China |

Publication type: Journal Article

Publication date: 2023-04-01

Elsevier

Phytochemistry

scimago Q1

wos Q1

SJR: 0.726

CiteScore: 6.9

Impact factor: 3.4

ISSN: 00319422, 18733700

DOI: 10.1016/j.phytochem.2023.113609

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PubMed ID: 36758886

Biochemistry

Molecular Biology

General Medicine

Plant Science

Horticulture

Abstract

Nine tetrahydrofuran lignans, including three undescribed spiro-lignans, were isolated from Isatis indigotica Fortune (Brassicaceae). Extensive spectroscopic analyses achieved the structure elucidation of these tetrahydrofuran lignans, and quantum chemical calculation combined with the MAEΔΔδ parameter. Notably, isatispironeols A-B have a unique spiro[dienone-tetrahydrofuran] molecular core. These spiro[dienone-tetrahydrofuran] lignans showed comparable neuroprotective effects as the positive control in the H2O2-induced SH-SY5Y cells model. In addition, (-)-(7R,8S,1'R,7'R,8'R)-isatispironeol A possessed more significant AChE inhibitory activity, further interact sites were also predicted by the in silico assay.

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GOST Copy

Xi Yu. F. et al. Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity // Phytochemistry. 2023. Vol. 208. p. 113609.

GOST all authors (up to 50) Copy

Xi Yu. F., Bai M., Zhang X., Hou Z. L., Lin B., Yao G. D., Lou L., Wang X., Song S., Huang X. Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity // Phytochemistry. 2023. Vol. 208. p. 113609.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.phytochem.2023.113609

UR - https://doi.org/10.1016/j.phytochem.2023.113609

TI - Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity

T2 - Phytochemistry

AU - Xi, Yu Fei

AU - Bai, Ming

AU - Zhang, Xin

AU - Hou, Zi Lin

AU - Lin, Bin

AU - Yao, Guo Dong

AU - Lou, Li-Li

AU - Wang, Xiaobo

AU - Song, Shao-Jiang

AU - Huang, Xiaoxiao

PY - 2023

DA - 2023/04/01

PB - Elsevier

SP - 113609

VL - 208

PMID - 36758886

SN - 0031-9422

SN - 1873-3700

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2023_Xi,

author = {Yu Fei Xi and Ming Bai and Xin Zhang and Zi Lin Hou and Bin Lin and Guo Dong Yao and Li-Li Lou and Xiaobo Wang and Shao-Jiang Song and Xiaoxiao Huang},

title = {Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity},

journal = {Phytochemistry},

year = {2023},

volume = {208},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.phytochem.2023.113609},

pages = {113609},

doi = {10.1016/j.phytochem.2023.113609}

}

Publisher

Elsevier

Journal

Phytochemistry

scimago Q1

wos Q1

SJR

0.726

CiteScore

6.9

Impact factor

3.4

ISSN

00319422 (Print)

18733700 (Electronic)

Profiles

Shao-Jiang Song