pages 221-234
Manipulating redox active metal metabolism to enhance cancer therapy
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Department of Radiation Oncology, The University of Iowa, Iowa City, IA, United States
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Publication type: Book Chapter
Publication date: 2020-01-24
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Abstract
Redox active metals, including iron, play essential roles in regulating cellular growth and metabolism. Approximately 2% of cellular iron is unbound and can participate in redox reactions. This labile iron pool (LIP) is tightly regulated by cells as excess LIP can participate in Fenton chemistry reactions generating reactive oxygen species. Many malignancies have increased iron uptake resulting in increased LIPs that contribute to cancer proliferation. Iron chelation therapy reduces LIPs and slows cancer progression. Alternatively, treatment with pharmacological ascorbate further increases cancer cell LIPs thereby increasing oxidative stress. Currently multiple clinical trials are combining pharmacological ascorbate with radiation and chemotherapy in a variety of cancers. Drugs containing redox active catalytic metals are also reducing radiation and chemotherapy-induced toxicity. The superoxide dismutase mimetic, GC4419, contains a catalytically active Mn2 + ion that dismutes superoxide radicals and protects against radiation and chemotherapy induced mucositis in head and neck cancer patients.
Citations by journals
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1
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ACS Applied Bio Materials
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ACS Applied Bio Materials
1 publication, 100%
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1
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Citations by publishers
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1
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 100%
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1
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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