Mendeleev Communications, volume 31, issue 1, pages 42-45

Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors

Publication typeJournal Article
Publication date2021-01-01
Quartile SCImago
Q3
Quartile WOS
Q3
Impact factor1.9
ISSN09599436, 1364551X
General Chemistry
Abstract
A simple and effective protocol for the synthesis of 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides includes a transformation of accessible 3,4-diacetyl-5-methyl-1H-pyrazoles into the corresponding 1,4-dioximes followed by their N2O4- mediated oxidative cyclization. All transformations proceed under mild conditions in good to high yields. According to the Griess assay, synthesized 2H-pyrazolo[3,4-d]pyridazine 5,6-dioxides showed promising NO-donor profiles producing NO in a wide range of concentrations.

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GOST Copy
Kulikov A. et al. Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors // Mendeleev Communications. 2021. Vol. 31. No. 1. pp. 42-45.
GOST all authors (up to 50) Copy
Kulikov A., Epishina M. A., Zhilin E. S., Shuvaev A. D., Fershtat L. L., Makhova N. N. Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors // Mendeleev Communications. 2021. Vol. 31. No. 1. pp. 42-45.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/J.MENCOM.2021.01.012
UR - https://doi.org/10.1016%2FJ.MENCOM.2021.01.012
TI - Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors
T2 - Mendeleev Communications
AU - Kulikov, Alexander
AU - Epishina, Margarita A.
AU - Zhilin, Egor S
AU - Shuvaev, Alexander D
AU - Fershtat, Leonid L.
AU - Makhova, Nina N.
PY - 2021
DA - 2021/01/01 00:00:00
PB - Elsevier
SP - 42-45
IS - 1
VL - 31
SN - 0959-9436
SN - 1364-551X
ER -
BibTex |
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BibTex Copy
@article{2021_Kulikov
author = {Alexander Kulikov and Margarita A. Epishina and Egor S Zhilin and Alexander D Shuvaev and Leonid L. Fershtat and Nina N. Makhova},
title = {Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors},
journal = {Mendeleev Communications},
year = {2021},
volume = {31},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2FJ.MENCOM.2021.01.012},
number = {1},
pages = {42--45},
doi = {10.1016/J.MENCOM.2021.01.012}
}
MLA
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MLA Copy
Kulikov, Alexander, et al. “Design and synthesis of pyrazolo[3,4-d]pyridazine 5,6-dioxides as novel NO-donors.” Mendeleev Communications, vol. 31, no. 1, Jan. 2021, pp. 42-45. https://doi.org/10.1016%2FJ.MENCOM.2021.01.012.
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