Drug Discovery Today, volume 2, issue 9, pages 382-384
Reactive compounds and in vitro false positives in HTS
1
AMGEN, 1840 DeHavilland Drive, Thousand Oaks, CA 91320, USA. tel: +1 805 447 1064, fax: +1 805 499 5714
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Publication type: Journal Article
Publication date: 1997-09-01
Journal:
Drug Discovery Today
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 7.4
ISSN: 13596446, 18785832
Drug Discovery
Pharmacology
Abstract
An important component of the successful highthroughput screening (HTS) strategy in drug discovery is the ability to assess HTS structure-activity data, and to distinguish between promising drug leads and the many useless false positives that can plague screening efforts. The author discusses simple chemistry guidelines for the evaluation of ‘positives’ in biochemical screens, with the aim of selecting stable, non-covalent binders (ligands) and eliminating protein-reactive compounds (reagents) from consideration as drug leads at an early stage.
Citations by journals
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3 publications, 1.04%
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ACS Medicinal Chemistry Letters
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3 publications, 1.04%
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2 publications, 0.69%
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Nature Chemistry
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2 publications, 0.69%
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2 publications, 0.69%
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Angewandte Chemie
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Angewandte Chemie
2 publications, 0.69%
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Citations by publishers
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10
20
30
40
50
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70
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American Chemical Society (ACS)
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American Chemical Society (ACS)
66 publications, 22.92%
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Elsevier
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Elsevier
57 publications, 19.79%
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Springer Nature
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Wiley
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Wiley
35 publications, 12.15%
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SAGE
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SAGE
11 publications, 3.82%
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Taylor & Francis
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Future Medicine
3 publications, 1.04%
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, 2, 0.69%
2 publications, 0.69%
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American Society for Pharmacology and Experimental Therapeutics
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American Society for Pharmacology and Experimental Therapeutics
1 publication, 0.35%
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Bentham Science
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Bentham Science
1 publication, 0.35%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 0.35%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 0.35%
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Universidade De Sao Paulo
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Universidade De Sao Paulo, 1, 0.35%
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1 publication, 0.35%
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The Chemical Society of Japan
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1 publication, 0.35%
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Walter de Gruyter
1 publication, 0.35%
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American Association for the Advancement of Science (AAAS)
1 publication, 0.35%
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American Society for Microbiology
1 publication, 0.35%
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IGI Global
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1 publication, 0.35%
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Nippon Yakuri Gakkai, 1, 0.35%
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Thieme
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1 publication, 0.35%
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Oxford University Press
1 publication, 0.35%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Rishton G. M. Reactive compounds and in vitro false positives in HTS // Drug Discovery Today. 1997. Vol. 2. No. 9. pp. 382-384.
GOST all authors (up to 50)
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Rishton G. M. Reactive compounds and in vitro false positives in HTS // Drug Discovery Today. 1997. Vol. 2. No. 9. pp. 382-384.
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RIS
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TY - JOUR
DO - 10.1016/S1359-6446(97)01083-0
UR - https://doi.org/10.1016%2FS1359-6446%2897%2901083-0
TI - Reactive compounds and in vitro false positives in HTS
T2 - Drug Discovery Today
AU - Rishton, Gilbert M.
PY - 1997
DA - 1997/09/01 00:00:00
PB - Elsevier
SP - 382-384
IS - 9
VL - 2
SN - 1359-6446
SN - 1878-5832
ER -
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@article{1997_Rishton,
author = {Gilbert M. Rishton},
title = {Reactive compounds and in vitro false positives in HTS},
journal = {Drug Discovery Today},
year = {1997},
volume = {2},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2FS1359-6446%2897%2901083-0},
number = {9},
pages = {382--384},
doi = {10.1016/S1359-6446(97)01083-0}
}
Cite this
MLA
Copy
Rishton, Gilbert M.. “Reactive compounds and in vitro false positives in HTS.” Drug Discovery Today, vol. 2, no. 9, Sep. 1997, pp. 382-384. https://doi.org/10.1016%2FS1359-6446%2897%2901083-0.