The Lancet Infectious Diseases, volume 18, issue 3, pages 318-327
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
Tacconelli Evelina
,
Carrara Elena
,
Savoldi Alessia
,
Harbarth S
,
Mendelson Marc
,
Monnet Dominique L.
,
Pulcini Céline
,
KAHLMETER GUNNAR
,
Kluytmans Jan A.J.W.
,
Carmeli Yehuda
,
Ouellette Marc
,
Outterson Kevin
,
Patel Jean
,
Cavaleri Marco
,
Cox Edward M
,
Grayson M. L.
,
Hansen Paul
,
Singh Nalini
,
Theuretzbacher Ursula
,
Magrini Nicola
,
Aboderin A O
,
Al-Abri Seif S.
,
Awang Jalil Nordiah
,
Benzonana Nur
,
Bhattacharya Sanjay
,
Brink Adrian J.
,
Burkert Francesco Robert
,
Cars Otto
,
Cornaglia Giuseppe
,
Dyar Oliver
,
Friedrich Alexander W.
,
Gales Ana C.
,
Gandra Sumanth
,
Giske Christian G.
,
Goff Debra A.
,
Goossens Herman
,
Gottlieb Thomas
,
Guzman-Blanco Manuel
,
Hryniewicz Waleria
,
Kattula Deepthi
,
Jinks Timothy
,
Kerr Lawrence
,
Kieny Marie Paule
,
Kim Yang Soo
,
KOZLOV ROMAN S.
,
Labarca Jaime
,
Laxminarayan Ramanan
,
Leder Karin
,
Leibovici L.
,
Levy Hara Gabriel
,
Littman Jasper
,
Malhotra-Kumar Surbhi
,
Manchanda Vikas
,
Moja Lorenzo
,
Ndoye Babacar
,
Pan Angelo
,
Paterson David A.
,
Paul Mical
,
Qiu Haibo
,
Pardo Pilar Ramon
,
Rodríguez-Baño Jesús
,
Sengupta Sharmila
,
Sharland Mike
,
Si Mehand Massinissa
,
Silver Lynn
,
Song Wonkeung
,
Steinbakk Martin
,
Thomsen Jens
,
Thwaites G. E.
,
van der Meer J.
,
Van Kinh Nguyen
,
Vega Silvio
,
Villegas María Angeles
,
Wechsler-Fördös Agnes
,
Wertheim Heiman FL
,
Wesangula Evelyn
,
Woodford Neil
,
Yilmaz Fidan O
,
Zorzet Anna
Publication type: Journal Article
Publication date: 2018-03-01
Journal:
The Lancet Infectious Diseases
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 56.3
ISSN: 14733099, 14744457
Infectious Diseases
Abstract
BACKGROUND
The spread of antibiotic-resistant bacteria poses a substantial threat to morbidity and mortality worldwide. Due to its large public health and societal implications, multidrug-resistant tuberculosis has been long regarded by WHO as a global priority for investment in new drugs. In 2016, WHO was requested by member states to create a priority list of other antibiotic-resistant bacteria to support research and development of effective drugs.
METHODS
We used a multicriteria decision analysis method to prioritise antibiotic-resistant bacteria; this method involved the identification of relevant criteria to assess priority against which each antibiotic-resistant bacterium was rated. The final priority ranking of the antibiotic-resistant bacteria was established after a preference-based survey was used to obtain expert weighting of criteria.
FINDINGS
We selected 20 bacterial species with 25 patterns of acquired resistance and ten criteria to assess priority: mortality, health-care burden, community burden, prevalence of resistance, 10-year trend of resistance, transmissibility, preventability in the community setting, preventability in the health-care setting, treatability, and pipeline. We stratified the priority list into three tiers (critical, high, and medium priority), using the 33rd percentile of the bacterium's total scores as the cutoff. Critical-priority bacteria included carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, and carbapenem-resistant and third-generation cephalosporin-resistant Enterobacteriaceae. The highest ranked Gram-positive bacteria (high priority) were vancomycin-resistant Enterococcus faecium and meticillin-resistant Staphylococcus aureus. Of the bacteria typically responsible for community-acquired infections, clarithromycin-resistant Helicobacter pylori, and fluoroquinolone-resistant Campylobacter spp, Neisseria gonorrhoeae, and Salmonella typhi were included in the high-priority tier.
INTERPRETATION
Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria. The global strategy should include antibiotic-resistant bacteria responsible for community-acquired infections such as Salmonella spp, Campylobacter spp, N gonorrhoeae, and H pylori.
FUNDING
World Health Organization.
Citations by journals
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Antibiotics
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Antibiotics
184 publications, 5.51%
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Frontiers in Microbiology
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Frontiers in Microbiology
126 publications, 3.78%
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Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy
70 publications, 2.1%
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Microorganisms
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Microorganisms
69 publications, 2.07%
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Microbiology spectrum
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Microbiology spectrum
65 publications, 1.95%
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Scientific Reports
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Scientific Reports
53 publications, 1.59%
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Journal of Antimicrobial Chemotherapy
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Journal of Antimicrobial Chemotherapy
53 publications, 1.59%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
51 publications, 1.53%
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Infection and Drug Resistance
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Infection and Drug Resistance
47 publications, 1.41%
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Frontiers in Cellular and Infection Microbiology
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Frontiers in Cellular and Infection Microbiology
46 publications, 1.38%
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Journal of Global Antimicrobial Resistance
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Journal of Global Antimicrobial Resistance
39 publications, 1.17%
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International Journal of Antimicrobial Agents
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International Journal of Antimicrobial Agents
38 publications, 1.14%
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ACS Infectious Diseases
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ACS Infectious Diseases
35 publications, 1.05%
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mBio
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mBio
31 publications, 0.93%
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Pathogens
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Pathogens
29 publications, 0.87%
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PLoS ONE
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PLoS ONE
29 publications, 0.87%
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Molecules
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Molecules
28 publications, 0.84%
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Clinical Microbiology and Infection
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Clinical Microbiology and Infection
27 publications, 0.81%
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Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry
26 publications, 0.78%
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Microbial genomics
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Microbial genomics
25 publications, 0.75%
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Nature Communications
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Nature Communications
25 publications, 0.75%
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Antimicrobial Resistance and Infection Control
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Antimicrobial Resistance and Infection Control
24 publications, 0.72%
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Clinical Infectious Diseases
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Clinical Infectious Diseases
23 publications, 0.69%
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Pharmaceutics
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Pharmaceutics
21 publications, 0.63%
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Frontiers in Immunology
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Frontiers in Immunology
19 publications, 0.57%
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Pharmaceuticals
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Pharmaceuticals
19 publications, 0.57%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
19 publications, 0.57%
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European Journal of Clinical Microbiology and Infectious Diseases
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European Journal of Clinical Microbiology and Infectious Diseases
18 publications, 0.54%
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Expert Review of Anti-Infective Therapy
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Expert Review of Anti-Infective Therapy
16 publications, 0.48%
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Citations by publishers
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100
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700
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Elsevier
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Elsevier
645 publications, 19.33%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
552 publications, 16.54%
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Springer Nature
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Springer Nature
402 publications, 12.05%
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Frontiers Media S.A.
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Frontiers Media S.A.
244 publications, 7.31%
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American Society for Microbiology
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American Society for Microbiology
240 publications, 7.19%
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Wiley
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Wiley
181 publications, 5.42%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
153 publications, 4.58%
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Oxford University Press
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Oxford University Press
136 publications, 4.08%
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Taylor & Francis
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Taylor & Francis
84 publications, 2.52%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
69 publications, 2.07%
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Dove Medical Press
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Dove Medical Press
51 publications, 1.53%
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Public Library of Science (PLoS)
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Public Library of Science (PLoS)
50 publications, 1.5%
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Microbiology Society
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Microbiology Society
49 publications, 1.47%
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Wolters Kluwer Health
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Wolters Kluwer Health
31 publications, 0.93%
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Mary Ann Liebert
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Mary Ann Liebert
22 publications, 0.66%
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Bentham Science
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Bentham Science
21 publications, 0.63%
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Hindawi Limited
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Hindawi Limited
13 publications, 0.39%
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SAGE
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SAGE
12 publications, 0.36%
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Thieme
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Thieme
12 publications, 0.36%
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Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS)
12 publications, 0.36%
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Future Medicine
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Future Medicine
11 publications, 0.33%
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American Society for Biochemistry and Molecular Biology
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American Society for Biochemistry and Molecular Biology
10 publications, 0.3%
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Pleiades Publishing
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Pleiades Publishing
10 publications, 0.3%
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American Association for the Advancement of Science (AAAS)
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American Association for the Advancement of Science (AAAS)
8 publications, 0.24%
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PeerJ
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PeerJ
7 publications, 0.21%
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F1000 Research
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F1000 Research
6 publications, 0.18%
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eLife Sciences Publications
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eLife Sciences Publications
5 publications, 0.15%
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Centers for Disease Control and Prevention (CDC)
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Centers for Disease Control and Prevention (CDC)
4 publications, 0.12%
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Portland Press
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Portland Press
4 publications, 0.12%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Tacconelli E. et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis // The Lancet Infectious Diseases. 2018. Vol. 18. No. 3. pp. 318-327.
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Tacconelli E. et al. Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis // The Lancet Infectious Diseases. 2018. Vol. 18. No. 3. pp. 318-327.
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TY - JOUR
DO - 10.1016/S1473-3099(17)30753-3
UR - https://doi.org/10.1016%2FS1473-3099%2817%2930753-3
TI - Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis
T2 - The Lancet Infectious Diseases
AU - Tacconelli, Evelina
AU - Carrara, Elena
AU - Savoldi, Alessia
AU - Harbarth, S
AU - Mendelson, Marc
AU - Monnet, Dominique L.
AU - Pulcini, Céline
AU - KAHLMETER, GUNNAR
AU - Kluytmans, Jan A.J.W.
AU - Carmeli, Yehuda
AU - Ouellette, Marc
AU - Outterson, Kevin
AU - Patel, Jean
AU - Cavaleri, Marco
AU - Cox, Edward M
AU - Houchens, Christopher R
AU - Grayson, M. L.
AU - Hansen, Paul
AU - Singh, Nalini
AU - Theuretzbacher, Ursula
AU - Magrini, Nicola
AU - Aboderin, A O
AU - Al-Abri, Seif S.
AU - Awang Jalil, Nordiah
AU - Benzonana, Nur
AU - Bhattacharya, Sanjay
AU - Brink, Adrian J.
AU - Burkert, Francesco Robert
AU - Cars, Otto
AU - Cornaglia, Giuseppe
AU - Dyar, Oliver
AU - Friedrich, Alexander W.
AU - Gales, Ana C.
AU - Gandra, Sumanth
AU - Giske, Christian G.
AU - Goff, Debra A.
AU - Goossens, Herman
AU - Gottlieb, Thomas
AU - Guzman-Blanco, Manuel
AU - Hryniewicz, Waleria
AU - Kattula, Deepthi
AU - Jinks, Timothy
AU - Kanj, Souha S.
AU - Kerr, Lawrence
AU - Kieny, Marie Paule
AU - Kim, Yang Soo
AU - KOZLOV, ROMAN S.
AU - Labarca, Jaime
AU - Laxminarayan, Ramanan
AU - Leder, Karin
AU - Leibovici, L.
AU - Levy Hara, Gabriel
AU - Littman, Jasper
AU - Malhotra-Kumar, Surbhi
AU - Manchanda, Vikas
AU - Moja, Lorenzo
AU - Ndoye, Babacar
AU - Pan, Angelo
AU - Paterson, David A.
AU - Paul, Mical
AU - Qiu, Haibo
AU - Pardo, Pilar Ramon
AU - Rodríguez-Baño, Jesús
AU - Sanguinetti, Maurizio
AU - Sengupta, Sharmila
AU - Sharland, Mike
AU - Si Mehand, Massinissa
AU - Silver, Lynn
AU - Song, Wonkeung
AU - Steinbakk, Martin
AU - Thomsen, Jens
AU - Thwaites, G. E.
AU - van der Meer, J.
AU - Van Kinh, Nguyen
AU - Vega, Silvio
AU - Villegas, María Angeles
AU - Wechsler-Fördös, Agnes
AU - Wertheim, Heiman FL
AU - Wesangula, Evelyn
AU - Woodford, Neil
AU - Yilmaz, Fidan O
AU - Zorzet, Anna
PY - 2018
DA - 2018/03/01 00:00:00
PB - Elsevier
SP - 318-327
IS - 3
VL - 18
SN - 1473-3099
SN - 1474-4457
ER -
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@article{2018_Tacconelli,
author = {Evelina Tacconelli and Elena Carrara and Alessia Savoldi and S Harbarth and Marc Mendelson and Dominique L. Monnet and Céline Pulcini and GUNNAR KAHLMETER and Jan A.J.W. Kluytmans and Yehuda Carmeli and Marc Ouellette and Kevin Outterson and Jean Patel and Marco Cavaleri and Edward M Cox and Christopher R Houchens and M. L. Grayson and Paul Hansen and Nalini Singh and Ursula Theuretzbacher and Nicola Magrini and A O Aboderin and Seif S. Al-Abri and Nordiah Awang Jalil and Nur Benzonana and Sanjay Bhattacharya and Adrian J. Brink and Francesco Robert Burkert and Otto Cars and Giuseppe Cornaglia and Oliver Dyar and Alexander W. Friedrich and Ana C. Gales and Sumanth Gandra and Christian G. Giske and Debra A. Goff and Herman Goossens and Thomas Gottlieb and Manuel Guzman-Blanco and Waleria Hryniewicz and Deepthi Kattula and Timothy Jinks and Souha S. Kanj and Lawrence Kerr and Marie Paule Kieny and Yang Soo Kim and ROMAN S. KOZLOV and Jaime Labarca and Ramanan Laxminarayan and Karin Leder and L. Leibovici and Gabriel Levy Hara and Jasper Littman and Surbhi Malhotra-Kumar and Vikas Manchanda and Lorenzo Moja and Babacar Ndoye and Angelo Pan and David A. Paterson and Mical Paul and Haibo Qiu and Pilar Ramon Pardo and Jesús Rodríguez-Baño and Maurizio Sanguinetti and Sharmila Sengupta and Mike Sharland and Massinissa Si Mehand and Lynn Silver and Wonkeung Song and Martin Steinbakk and Jens Thomsen and G. E. Thwaites and J. van der Meer and Nguyen Van Kinh and Silvio Vega and María Angeles Villegas and Agnes Wechsler-Fördös and Heiman FL Wertheim and Evelyn Wesangula and Neil Woodford and Fidan O Yilmaz and Anna Zorzet},
title = {Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis},
journal = {The Lancet Infectious Diseases},
year = {2018},
volume = {18},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016%2FS1473-3099%2817%2930753-3},
number = {3},
pages = {318--327},
doi = {10.1016/S1473-3099(17)30753-3}
}
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Tacconelli, Evelina, et al. “Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.” The Lancet Infectious Diseases, vol. 18, no. 3, Mar. 2018, pp. 318-327. https://doi.org/10.1016%2FS1473-3099%2817%2930753-3.