Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, volume 1861, issue 2, pages 178-189
One signal stimulates different transcriptional activation mechanisms
Mazina Marina Yu
1
,
Kovalenko Elena
1
,
Derevyanko Polina K
1
,
Nikolenko J V.
2
,
Krasnov Aleksey N.
2
,
Publication type: Journal Article
Publication date: 2018-02-06
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 4.7
ISSN: 18749399, 18764320
Biochemistry
Molecular Biology
Genetics
Structural Biology
Biophysics
Abstract
Transcriptional activation is often represented as a "one-step process" that involves the simultaneous recruitment of co-activator proteins, leading to a change in gene status. Using Drosophila developmental ecdysone-dependent genes as a model, we demonstrated that activation of transcription is instead a continuous process that consists of a number of steps at which different phases of transcription (initiation or elongation) are stimulated. Thorough evaluation of the behaviour of multiple transcriptional complexes during the early activation process has shown that the pathways by which activation proceeds for different genes may vary considerably, even in response to the same induction signal. RNA polymerase II recruitment is an important step that is involved in one of the pathways. RNA polymerase II recruitment is accompanied by the recruitment of a significant number of transcriptional coactivators as well as slight changes in the chromatin structure. The second pathway involves the stimulation of transcriptional elongation as its key step. The level of coactivator binding to the promoter shows almost no increase, whereas chromatin modification levels change significantly.
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Citations by publishers
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5 publications, 33.33%
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1 publication, 6.67%
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1 publication, 6.67%
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Mazina M. Yu. et al. One signal stimulates different transcriptional activation mechanisms // Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2018. Vol. 1861. No. 2. pp. 178-189.
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Mazina M. Yu., Kovalenko E., Derevyanko P. K., Nikolenko J. V., Krasnov A. N., Vorobyeva N. E. One signal stimulates different transcriptional activation mechanisms // Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 2018. Vol. 1861. No. 2. pp. 178-189.
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TY - JOUR
DO - 10.1016/j.bbagrm.2018.01.016
UR - https://doi.org/10.1016%2Fj.bbagrm.2018.01.016
TI - One signal stimulates different transcriptional activation mechanisms
T2 - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
AU - Mazina, Marina Yu
AU - Kovalenko, Elena
AU - Derevyanko, Polina K
AU - Nikolenko, J V.
AU - Krasnov, Aleksey N.
AU - Vorobyeva, N. E.
PY - 2018
DA - 2018/02/06 00:00:00
PB - Elsevier
SP - 178-189
IS - 2
VL - 1861
SN - 1874-9399
SN - 1876-4320
ER -
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@article{2018_Mazina,
author = {Marina Yu Mazina and Elena Kovalenko and Polina K Derevyanko and J V. Nikolenko and Aleksey N. Krasnov and N. E. Vorobyeva},
title = {One signal stimulates different transcriptional activation mechanisms},
journal = {Biochimica et Biophysica Acta - Gene Regulatory Mechanisms},
year = {2018},
volume = {1861},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.bbagrm.2018.01.016},
number = {2},
pages = {178--189},
doi = {10.1016/j.bbagrm.2018.01.016}
}
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Mazina, Marina Yu., et al. “One signal stimulates different transcriptional activation mechanisms.” Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, vol. 1861, no. 2, Feb. 2018, pp. 178-189. https://doi.org/10.1016%2Fj.bbagrm.2018.01.016.
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