Biochemical Pharmacology, volume 169, pages 113638

Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics

Ning Baitang ¹

Yu Dianke ²

Yu Ai-Ming ³

Hide authors affiliations Show authors affiliations: 3 affiliations

National Center for Toxicological Research (NCTR), US Food and Drug Administration, Jefferson, AR 72079, USA |

School of Public health, Qingdao University, Qingdao, China |

Department of Biochemistry and Molecular Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA |

Publication type: Journal Article

Publication date: 2019-11-01

Elsevier

Journal: Biochemical Pharmacology

Quartile SCImago

Quartile WOS

Impact factor: 5.8

ISSN: 00062952, 18732968

DOI: 10.1016/j.bcp.2019.113638

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PubMed ID: 31518552

Biochemistry

Pharmacology

Abstract

Accumulating evidence has demonstrated that genome-derived noncoding RNAs (ncRNAs) play important roles in modulating inter-individual variations observed in drug metabolism and disposition by controlling the expression of genes coding drug metabolizing enzymes and transporters (DMETs) and relevant nuclear receptors (NRs). With the understanding of novel ncRNA regulatory mechanisms and significance in the control of disease initiation and progression, RNA-based therapies are under active investigation that may expand the druggable targets from conventional proteins to RNAs and the genome for the treatment of human diseases. Herein we provide an overview of research strategies, approaches and their limitations in biochemical and pharmacological studies pertaining to ncRNA functions in the regulation of drug and nutrient metabolism and disposition, and discussion on the promise and challenges in developing RNA therapeutics.

By date By citations

Citations by journals

	1 2 3 4
Frontiers in Genetics	Frontiers in Genetics, 4, 10.81% Frontiers in Genetics 4 publications, 10.81%
Genes	Genes, 3, 8.11% Genes 3 publications, 8.11%
Nucleic Acids Research	Nucleic Acids Research, 3, 8.11% Nucleic Acids Research 3 publications, 8.11%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 2, 5.41% International Journal of Molecular Sciences 2 publications, 5.41%
Journal of Cancer Research and Clinical Oncology	Journal of Cancer Research and Clinical Oncology, 1, 2.7% Journal of Cancer Research and Clinical Oncology 1 publication, 2.7%
Drug Metabolism and Disposition	Drug Metabolism and Disposition, 1, 2.7% Drug Metabolism and Disposition 1 publication, 2.7%
Molecular Pharmacology	Molecular Pharmacology, 1, 2.7% Molecular Pharmacology 1 publication, 2.7%
Non-coding RNA	Non-coding RNA, 1, 2.7% Non-coding RNA 1 publication, 2.7%
Cancers	Cancers, 1, 2.7% Cancers 1 publication, 2.7%
Pharmaceutics	Pharmaceutics, 1, 2.7% Pharmaceutics 1 publication, 2.7%
Antioxidants	Antioxidants, 1, 2.7% Antioxidants 1 publication, 2.7%
Frontiers in Immunology	Frontiers in Immunology, 1, 2.7% Frontiers in Immunology 1 publication, 2.7%
Frontiers in Oncology	Frontiers in Oncology, 1, 2.7% Frontiers in Oncology 1 publication, 2.7%
Archives of Toxicology	Archives of Toxicology, 1, 2.7% Archives of Toxicology 1 publication, 2.7%
Current Clinical Microbiology Reports	Current Clinical Microbiology Reports, 1, 2.7% Current Clinical Microbiology Reports 1 publication, 2.7%
Advanced Drug Delivery Reviews	Advanced Drug Delivery Reviews, 1, 2.7% Advanced Drug Delivery Reviews 1 publication, 2.7%
Life Sciences	Life Sciences, 1, 2.7% Life Sciences 1 publication, 2.7%
Pharmacology and Therapeutics	Pharmacology and Therapeutics, 1, 2.7% Pharmacology and Therapeutics 1 publication, 2.7%
Molecular Therapy - Oncolytics	Molecular Therapy - Oncolytics, 1, 2.7% Molecular Therapy - Oncolytics 1 publication, 2.7%
Expert Opinion on Drug Metabolism and Toxicology	Expert Opinion on Drug Metabolism and Toxicology, 1, 2.7% Expert Opinion on Drug Metabolism and Toxicology 1 publication, 2.7%
Drug Metabolism Reviews	Drug Metabolism Reviews, 1, 2.7% Drug Metabolism Reviews 1 publication, 2.7%
Toxicological Sciences	Toxicological Sciences, 1, 2.7% Toxicological Sciences 1 publication, 2.7%
Journal of Thoracic Disease	Journal of Thoracic Disease, 1, 2.7% Journal of Thoracic Disease 1 publication, 2.7%
Experimental and Therapeutic Medicine	Experimental and Therapeutic Medicine, 1, 2.7% Experimental and Therapeutic Medicine 1 publication, 2.7%
Non-coding RNA Research	Non-coding RNA Research, 1, 2.7% Non-coding RNA Research 1 publication, 2.7%
Annual Review of Pharmacology and Toxicology	Annual Review of Pharmacology and Toxicology, 1, 2.7% Annual Review of Pharmacology and Toxicology 1 publication, 2.7%
Biochimica et Biophysica Acta - Reviews on Cancer	Biochimica et Biophysica Acta - Reviews on Cancer, 1, 2.7% Biochimica et Biophysica Acta - Reviews on Cancer 1 publication, 2.7%
	1 2 3 4

Citations by publishers

	1 2 3 4 5 6 7 8 9
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 9, 24.32% Multidisciplinary Digital Publishing Institute (MDPI) 9 publications, 24.32%
Frontiers Media S.A.	Frontiers Media S.A., 6, 16.22% Frontiers Media S.A. 6 publications, 16.22%
Elsevier	Elsevier, 5, 13.51% Elsevier 5 publications, 13.51%
Oxford University Press	Oxford University Press, 4, 10.81% Oxford University Press 4 publications, 10.81%
Springer Nature	Springer Nature, 3, 8.11% Springer Nature 3 publications, 8.11%
American Society for Pharmacology and Experimental Therapeutics	American Society for Pharmacology and Experimental Therapeutics, 2, 5.41% American Society for Pharmacology and Experimental Therapeutics 2 publications, 5.41%
Taylor & Francis	Taylor & Francis, 2, 5.41% Taylor & Francis 2 publications, 5.41%
AME Publishing Company	AME Publishing Company, 1, 2.7% AME Publishing Company 1 publication, 2.7%
Spandidos Publications	Spandidos Publications, 1, 2.7% Spandidos Publications 1 publication, 2.7%
KeAi Communications Co.	KeAi Communications Co., 1, 2.7% KeAi Communications Co. 1 publication, 2.7%
Annual Reviews	Annual Reviews, 1, 2.7% Annual Reviews 1 publication, 2.7%
	1 2 3 4 5 6 7 8 9

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Ning B., Yu D., Yu A. Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics // Biochemical Pharmacology. 2019. Vol. 169. p. 113638.

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Ning B., Yu D., Yu A. Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics // Biochemical Pharmacology. 2019. Vol. 169. p. 113638.

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RIS Copy

TY - JOUR

DO - 10.1016/j.bcp.2019.113638

UR - https://doi.org/10.1016%2Fj.bcp.2019.113638

TI - Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics

T2 - Biochemical Pharmacology

AU - Ning, Baitang

AU - Yu, Dianke

AU - Yu, Ai-Ming

PY - 2019

DA - 2019/11/01 00:00:00

PB - Elsevier

SP - 113638

VL - 169

PMID - 31518552

SN - 0006-2952

SN - 1873-2968

ER -

BibTex

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BibTex Copy

@article{2019_Ning,

author = {Baitang Ning and Dianke Yu and Ai-Ming Yu},

title = {Advances and challenges in studying noncoding RNA regulation of drug metabolism and development of RNA therapeutics},

journal = {Biochemical Pharmacology},

year = {2019},

volume = {169},

publisher = {Elsevier},

month = {nov},

url = {https://doi.org/10.1016%2Fj.bcp.2019.113638},

pages = {113638},

doi = {10.1016/j.bcp.2019.113638}

}

Found error?

Publisher

Elsevier

Journal

Biochemical Pharmacology

Quartile SCImago

Quartile WOS

Impact factor

5.8

ISSN

00062952 (Print)
18732968 (Electronic)