Open Access

Bioactive Materials, volume 4, pages 132-141

Surface bioactivation of PEEK by neutral atom beam technology

Khoury Joseph ¹

Selezneva Irina ²

Pestov Sergei ³

Tarassov Vadim ⁴

Ermakov Artem M. ²

Mikheev Andrey ²

Lazov Mikhail ³

Kirkpatrick Sean R ¹

Shashkov Dmitry ¹

Smolkov Alexandre ³

Hide authors affiliations Show authors affiliations: 4 affiliations

Exogenesis Corporation, Billerica, MA, USA. |

Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. |

“MIREA–Russian Technological University”, Moscow, Russia |

⁴

OAO Technotransservice Engineering, Moscow, Russia. |

Publication type: Journal Article

Publication date: 2019-12-01

KeAi Communications Co.

Journal: Bioactive Materials

Quartile SCImago

Quartile WOS

Impact factor: 18.9

ISSN: 2452199X

DOI: 10.1016/j.bioactmat.2019.02.001

Copy DOI

PubMed ID: 30873505

Biotechnology

Biomaterials

Biomedical Engineering

Abstract

Polyetheretherketone (PEEK) is an alternative to metallic implants and a material of choice in many applications, including orthopedic, spinal, trauma, and dental. While titanium (Ti) and Ti-alloys are widely used in many intraosseous implants due to its biocompatibility and ability to osseointegrate, negatives include stiffness which contributes to shear stress, radio-opacity, and Ti-sensitivity. Many surgeons prefer to use PEEK due to its biocompatibility, similar elasticity to bone, and radiolucency, however, due to its inert properties, it fails to fully integrate with bone. Accelerated Neutral Atom Beam (ANAB) technology has been successfully employed to demonstrate enhanced bioactivity of PEEK both in vitro and in vivo. In this study, we further characterize surfaces of PEEK modified by ANAB as well as elucidate attachment and genetic effects of dental pulp stem cells (DPSC) exposed to these surfaces. ANAB modification resulted in decreased contact angle at 72.9 ± 4.5° as compared to 92.4 ± 8.5° for control (p < 0.01) and a decreased average surface roughness, however with a nano-textured surface profile. ANAB treatment also increased the ability of DPSC attachment and proliferation with considerable genetic differences showing earlier progression towards osteogenic differentiation. This surface modification is achieved without adding a coating or changing the chemical composition of the PEEK material. Taken together, we show that ANAB processing of PEEK surface enhances the bioactivity of implantable medical devices without an additive or a coating.

By date By citations

Citations by journals

	1 2 3 4 5 6
Polymers	Polymers, 6, 15% Polymers 6 publications, 15%
Materials	Materials, 2, 5% Materials 2 publications, 5%
Materials Today Bio	Materials Today Bio, 2, 5% Materials Today Bio 2 publications, 5%
Materials and Design	Materials and Design, 2, 5% Materials and Design 2 publications, 5%
European Polymer Journal	European Polymer Journal, 2, 5% European Polymer Journal 2 publications, 5%
Biomaterials Science	Biomaterials Science, 2, 5% Biomaterials Science 2 publications, 5%
Journal of Composites Science	Journal of Composites Science, 1, 2.5% Journal of Composites Science 1 publication, 2.5%
Engineered Regeneration	Engineered Regeneration, 1, 2.5% Engineered Regeneration 1 publication, 2.5%
Smart Materials in Medicine	Smart Materials in Medicine, 1, 2.5% Smart Materials in Medicine 1 publication, 2.5%
Dental Materials	Dental Materials, 1, 2.5% Dental Materials 1 publication, 2.5%
Biomedical Materials (Bristol)	Biomedical Materials (Bristol), 1, 2.5% Biomedical Materials (Bristol) 1 publication, 2.5%
Progress in Biomaterials	Progress in Biomaterials, 1, 2.5% Progress in Biomaterials 1 publication, 2.5%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 1, 2.5% Colloids and Surfaces B: Biointerfaces 1 publication, 2.5%
Materials Science and Engineering C	Materials Science and Engineering C, 1, 2.5% Materials Science and Engineering C 1 publication, 2.5%
Bioactive Materials	Bioactive Materials, 1, 2.5% Bioactive Materials 1 publication, 2.5%
Journal of Proteomics	Journal of Proteomics, 1, 2.5% Journal of Proteomics 1 publication, 2.5%
The Innovation	The Innovation, 1, 2.5% The Innovation 1 publication, 2.5%
Journal of Materials Science and Technology	Journal of Materials Science and Technology, 1, 2.5% Journal of Materials Science and Technology 1 publication, 2.5%
Journal of Applied Polymer Science	Journal of Applied Polymer Science, 1, 2.5% Journal of Applied Polymer Science 1 publication, 2.5%
Polymers for Advanced Technologies	Polymers for Advanced Technologies, 1, 2.5% Polymers for Advanced Technologies 1 publication, 2.5%
Biomolecules	Biomolecules, 1, 2.5% Biomolecules 1 publication, 2.5%
Macromolecular Bioscience	Macromolecular Bioscience, 1, 2.5% Macromolecular Bioscience 1 publication, 2.5%
Regenerative Biomaterials	Regenerative Biomaterials, 1, 2.5% Regenerative Biomaterials 1 publication, 2.5%
Journal of Zhejiang University: Science B	Journal of Zhejiang University: Science B, 1, 2.5% Journal of Zhejiang University: Science B 1 publication, 2.5%
Advances in Polymer Technology	Advances in Polymer Technology, 1, 2.5% Advances in Polymer Technology 1 publication, 2.5%
Coatings	Coatings, 1, 2.5% Coatings 1 publication, 2.5%
ACS Biomaterials Science and Engineering	ACS Biomaterials Science and Engineering, 1, 2.5% ACS Biomaterials Science and Engineering 1 publication, 2.5%
ACS Applied Polymer Materials	ACS Applied Polymer Materials, 1, 2.5% ACS Applied Polymer Materials 1 publication, 2.5%
Frontiers in Mechanical Engineering	Frontiers in Mechanical Engineering, 1, 2.5% Frontiers in Mechanical Engineering 1 publication, 2.5%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10 12 14
Elsevier	Elsevier, 13, 32.5% Elsevier 13 publications, 32.5%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 11, 27.5% Multidisciplinary Digital Publishing Institute (MDPI) 11 publications, 27.5%
Wiley	Wiley, 4, 10% Wiley 4 publications, 10%
Springer Nature	Springer Nature, 2, 5% Springer Nature 2 publications, 5%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 2, 5% Royal Society of Chemistry (RSC) 2 publications, 5%
American Chemical Society (ACS)	American Chemical Society (ACS), 2, 5% American Chemical Society (ACS) 2 publications, 5%
IOP Publishing	IOP Publishing, 1, 2.5% IOP Publishing 1 publication, 2.5%
KeAi Communications Co.	KeAi Communications Co., 1, 2.5% KeAi Communications Co. 1 publication, 2.5%
Oxford University Press	Oxford University Press, 1, 2.5% Oxford University Press 1 publication, 2.5%
Zhejiang University Press	Zhejiang University Press, 1, 2.5% Zhejiang University Press 1 publication, 2.5%
Frontiers Media S.A.	Frontiers Media S.A., 1, 2.5% Frontiers Media S.A. 1 publication, 2.5%
	2 4 6 8 10 12 14

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Khoury J. et al. Surface bioactivation of PEEK by neutral atom beam technology // Bioactive Materials. 2019. Vol. 4. pp. 132-141.

GOST all authors (up to 50) Copy

Khoury J., Selezneva I., Pestov S., Tarassov V., Ermakov A. M., Mikheev A., Lazov M., Kirkpatrick S. R., Shashkov D., Smolkov A. Surface bioactivation of PEEK by neutral atom beam technology // Bioactive Materials. 2019. Vol. 4. pp. 132-141.

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RIS Copy

TY - JOUR

DO - 10.1016/j.bioactmat.2019.02.001

UR - https://doi.org/10.1016%2Fj.bioactmat.2019.02.001

TI - Surface bioactivation of PEEK by neutral atom beam technology

T2 - Bioactive Materials

AU - Khoury, Joseph

AU - Selezneva, Irina

AU - Pestov, Sergei

AU - Tarassov, Vadim

AU - Ermakov, Artem M.

AU - Mikheev, Andrey

AU - Lazov, Mikhail

AU - Kirkpatrick, Sean R

AU - Shashkov, Dmitry

AU - Smolkov, Alexandre

PY - 2019

DA - 2019/12/01 00:00:00

PB - KeAi Communications Co.

SP - 132-141

VL - 4

PMID - 30873505

SN - 2452-199X

ER -

BibTex

Cite this

BibTex Copy

@article{2019_Khoury,

author = {Joseph Khoury and Irina Selezneva and Sergei Pestov and Vadim Tarassov and Artem M. Ermakov and Andrey Mikheev and Mikhail Lazov and Sean R Kirkpatrick and Dmitry Shashkov and Alexandre Smolkov},

title = {Surface bioactivation of PEEK by neutral atom beam technology},

journal = {Bioactive Materials},

year = {2019},

volume = {4},

publisher = {KeAi Communications Co.},

month = {dec},

url = {https://doi.org/10.1016%2Fj.bioactmat.2019.02.001},

pages = {132--141},

doi = {10.1016/j.bioactmat.2019.02.001}

}

Found error?

Publisher

KeAi Communications Co.

Journal

Bioactive Materials

Quartile SCImago

Quartile WOS

Impact factor

18.9

ISSN

2452199X (Print)

Labs

Laboratory of Cell and Tissue Growth

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