Biochimie, volume 28, issue SUPPL. 3, pages 1827-1831
Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA
Petrenko Anatolii
1
,
Korolenkova L I
1
,
Skvortsov Dmitry
2
,
Fedorova M D
1
,
Skoblov M U
3
,
Baranova Ancha
3
,
Zvereva Maria
2
,
Rubtsova M. P.
2
,
Kisseljov F L
1
Publication type: Journal Article
Publication date: 2010-12-01
Biochemistry
General Medicine
Abstract
Cervical cancers are characterized by the persistence of human papilloma virus (HPV) genome that is found in tissue samples starting from the early stages of tumor progression. Just like in other tumors, the activation of telomerase was observed in cervical carcinomas, but information about its expression was controversial. The aim of this study is to find possible correlations between the presence of HPV sequences, activity of telomerase and expression of different spliced forms of hTERT RNA in cervical intraepithelial neoplasias (CIN). The results show that HPV DNA is present in 60% of normal tissue adjacent to CIN lesions and up to 84% in CIN samples. Telomerase activity was found in 28% of adjacent normal tissue and in 68% of CIN II-III. hTERT RNA that encodes an active enzyme was present almost in all CIN samples. Variations in levels of telomerase activity are possibly not regulated by the splicing forms of hTERT mRNA with deletions.
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- We do not take into account publications that without a DOI.
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Petrenko A. et al. Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA // Biochimie. 2010. Vol. 28. No. SUPPL. 3. pp. 1827-1831.
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Petrenko A., Korolenkova L. I., Skvortsov D., Fedorova M. D., Skoblov M. U., Baranova A., Zvereva M., Rubtsova M. P., Kisseljov F. L. Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA // Biochimie. 2010. Vol. 28. No. SUPPL. 3. pp. 1827-1831.
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TY - JOUR
DO - 10.1016/j.biochi.2010.07.015
UR - https://doi.org/10.1016%2Fj.biochi.2010.07.015
TI - Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA
T2 - Biochimie
AU - Petrenko, Anatolii
AU - Korolenkova, L I
AU - Skvortsov, Dmitry
AU - Fedorova, M D
AU - Skoblov, M U
AU - Baranova, Ancha
AU - Zvereva, Maria
AU - Rubtsova, M. P.
AU - Kisseljov, F L
PY - 2010
DA - 2010/12/01 00:00:00
PB - Elsevier
SP - 1827-1831
IS - SUPPL. 3
VL - 28
SN - 0300-9084
SN - 6183-1638
ER -
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@article{2010_Petrenko,
author = {Anatolii Petrenko and L I Korolenkova and Dmitry Skvortsov and M D Fedorova and M U Skoblov and Ancha Baranova and Maria Zvereva and M. P. Rubtsova and F L Kisseljov},
title = {Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA},
journal = {Biochimie},
year = {2010},
volume = {28},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.biochi.2010.07.015},
number = {SUPPL. 3},
pages = {1827--1831},
doi = {10.1016/j.biochi.2010.07.015}
}
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Petrenko, Anatolii, et al. “Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA.” Biochimie, vol. 28, no. SUPPL. 3, Dec. 2010, pp. 1827-1831. https://doi.org/10.1016%2Fj.biochi.2010.07.015.