Biochimie, volume 192, pages 63-71

Biological evaluation and spectral characterization of a novel tetracenomycin X congener

Alferova Vera A ^{1, 2}

Tashlitsky Vadim N. ³

Maviza Tinashe P ⁴

Biryukov Mikhail V

Zakalyukina Yuliya V ^{5, 6}

Lukianov Dmitrii A

Osterman Ilya A ^{4, 7}

Skvortsov Dmitry A.

Vasilyeva Lilia A ³

Skvortsov Dmitry ³

Polshakov Vladimir I. ⁸

Sergiev Petr V. ^{4, 9}

Korshun Vladimir A. ²

Hide authors affiliations Show authors affiliations: 9 affiliations

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, Moscow, 117997, Russia. |

Gause Institute of New Antibiotics, Bolshaya Pirogovskaya 11, Moscow, 119021, Russia |

Department of Chemistry, Lomonosov Moscow State University, Moscow 119992, Russia. |

⁴

Center of Life Sciences, Skolkovo Institute of Science and Technology, Skolkovo, 143028, Russia |

⁵

Department of Soil Science, Lomonosov Moscow State University, Moscow, 119234, Russia. |

⁶

Genetics and Life Sciences Research Center, Sirius University of Science and Technology, Sochi, 354340, Russia |

⁷

Department of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia |

⁸

Center for Magnetic Tomography and Spectroscopy, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow 119991, Russia |

⁹

Department of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia. |

Publication type: Journal Article

Publication date: 2022-01-01

Elsevier

Journal: Biochimie

Quartile SCImago

Quartile WOS

Impact factor: 3.9

ISSN: 03009084, 61831638

DOI: 10.1016/j.biochi.2021.09.014

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Biochemistry

General Medicine

Abstract

The aromatic polyketide tetracenomycin X (TcmX) was recently found to be a potent inhibitor of protein synthesis; its binding site is located in a unique locus within the tunnel of the large ribosomal subunit. The distinct mode of action makes this relatively narrow class of aromatic polyketides promising for drug development in our quest to prevent the spread of drug-resistant pathogens. Here we report the isolation and structure elucidation of a novel natural tetracenomycin X congener - 6-hydroxytetraceonomycin X (6-OH-TcmX). In contrast to TcmX, 6-OH-TcmX exhibited lower antimicrobial and cytotoxic activity, but comparable in vitro protein synthesis inhibition ability. A survey on spectral properties of tetracenomycins revealed profound differences in both UV-absorption and fluorescence spectra between TcmX and 6-OH-TcmX, suggesting a significant influence of 6-hydroxylation on the tetracenomycin X chromophore. Nonetheless, characteristic spectral properties of tetracenomycins make them suitable candidates for semi-synthetic drug development (e.g., for targeted delivery, chemical biology, or cell imaging).

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Antonie van Leeuwenhoek	Antonie van Leeuwenhoek, 1, 20% Antonie van Leeuwenhoek 1 publication, 20%
Biochimie	Biochimie, 1, 20% Biochimie 1 publication, 20%
Eurasian Soil Science	Eurasian Soil Science, 1, 20% Eurasian Soil Science 1 publication, 20%
ACS Omega	ACS Omega, 1, 20% ACS Omega 1 publication, 20%
International Journal of Molecular Sciences	International Journal of Molecular Sciences, 1, 20% International Journal of Molecular Sciences 1 publication, 20%
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Springer Nature	Springer Nature, 1, 20% Springer Nature 1 publication, 20%
Elsevier	Elsevier, 1, 20% Elsevier 1 publication, 20%
Pleiades Publishing	Pleiades Publishing, 1, 20% Pleiades Publishing 1 publication, 20%
American Chemical Society (ACS)	American Chemical Society (ACS), 1, 20% American Chemical Society (ACS) 1 publication, 20%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 1, 20% Multidisciplinary Digital Publishing Institute (MDPI) 1 publication, 20%
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Alferova V. A. et al. Biological evaluation and spectral characterization of a novel tetracenomycin X congener // Biochimie. 2022. Vol. 192. pp. 63-71.

GOST all authors (up to 50) Copy

Alferova V. A., Maviza T. P., Biryukov M. V., Zakalyukina Y. V., Lukianov D. A., Tashlitsky V. N., Osterman I. A., Skvortsov D. A., Vasilyeva L. A., Skvortsov D., Polshakov V. I., Sergiev P. V., Korshun V. A. Biological evaluation and spectral characterization of a novel tetracenomycin X congener // Biochimie. 2022. Vol. 192. pp. 63-71.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.biochi.2021.09.014

UR - https://doi.org/10.1016%2Fj.biochi.2021.09.014

TI - Biological evaluation and spectral characterization of a novel tetracenomycin X congener

T2 - Biochimie

AU - Alferova, Vera A

AU - Maviza, Tinashe P

AU - Biryukov, Mikhail V

AU - Zakalyukina, Yuliya V

AU - Lukianov, Dmitrii A

AU - Tashlitsky, Vadim N.

AU - Osterman, Ilya A

AU - Skvortsov, Dmitry A.

AU - Vasilyeva, Lilia A

AU - Skvortsov, Dmitry

AU - Polshakov, Vladimir I.

AU - Sergiev, Petr V.

AU - Korshun, Vladimir A.

PY - 2022

DA - 2022/01/01 00:00:00

PB - Elsevier

SP - 63-71

VL - 192

SN - 0300-9084

SN - 6183-1638

ER -

BibTex

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BibTex Copy

@article{2022_Alferova,

author = {Vera A Alferova and Tinashe P Maviza and Mikhail V Biryukov and Yuliya V Zakalyukina and Dmitrii A Lukianov and Vadim N. Tashlitsky and Ilya A Osterman and Dmitry A. Skvortsov and Lilia A Vasilyeva and Dmitry Skvortsov and Vladimir I. Polshakov and Petr V. Sergiev and Vladimir A. Korshun},

title = {Biological evaluation and spectral characterization of a novel tetracenomycin X congener},

journal = {Biochimie},

year = {2022},

volume = {192},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016%2Fj.biochi.2021.09.014},

pages = {63--71},

doi = {10.1016/j.biochi.2021.09.014}

}

Found error?

Publisher

Elsevier

Journal

Biochimie

Quartile SCImago

Quartile WOS

Impact factor

3.9

ISSN

03009084 (Print)
61831638 (Electronic)

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