Open Access

Biomaterials, volume 183, pages 1-9

2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy.

Xiao Wanyue ¹

Wang Peng ¹

Ou Changjin ¹

Huang Xiaoyu ¹

TANG YUNYUN ¹

Wu Meiyan ¹

Si Weili ¹

Shao Jinjun ¹

Huang Wei

Dong Xiaochen ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211800, China |

Publication type: Journal Article

Publication date: 2018-11-01

Elsevier

Journal: Biomaterials

Quartile SCImago

Quartile WOS

Impact factor: 14

ISSN: 01429612, 18785905

DOI: 10.1016/j.biomaterials.2018.08.034

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Ceramics and Composites

Biophysics

Bioengineering

Biomaterials

Mechanics of Materials

Abstract

To overcome irradiation-dependence of cancer phototherapy, a near infrared aza-BODIPY-based photothermogenic photosensitizer BDY with 2-Pyridone group has been synthesized for imaging-guided photothermal synergistic sustainable photodynamic therapy. Multifunctional water-soluble BDY nanoparticles (NPs), with high photothermal conversion efficiency of 35.7% and excellent singlet oxygen (1O2) generation ability, are prepared by self-assembling. The reversible transformation between 2-pyridone moiety and its endoperoxide form endows BDY with continuous 1O2 generation ability under illumination and non-illumination conditions. Simultaneously, BDY NPs exhibit excellent tumor targeting properties by enhanced permeability and retention (EPR) effect and photoacoustic imaging (PAI) ability. Furthermore, the photothermal assisted sustainable photodynamic therapy can significantly inhibit tumor growth (93.4% inhibition) with almost no side effects by intermittent laser illumination. The finding highlights that this photothermal synergistic sustainable phototherapy presents great potential for clinical applications.

By date By citations

Citations by journals

	1 2 3 4 5 6 7
Dyes and Pigments	Dyes and Pigments, 7, 7.45% Dyes and Pigments 7 publications, 7.45%
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 6, 6.38% Coordination Chemistry Reviews 6 publications, 6.38%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 4, 4.26% Angewandte Chemie - International Edition 4 publications, 4.26%
Angewandte Chemie	Angewandte Chemie, 4, 4.26% Angewandte Chemie 4 publications, 4.26%
Small	Small, 3, 3.19% Small 3 publications, 3.19%
ACS applied materials & interfaces	ACS applied materials & interfaces, 3, 3.19% ACS applied materials & interfaces 3 publications, 3.19%
ACS Nano	ACS Nano, 3, 3.19% ACS Nano 3 publications, 3.19%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 3, 3.19% Journal of Materials Chemistry B 3 publications, 3.19%
Journal of Porphyrins and Phthalocyanines	Journal of Porphyrins and Phthalocyanines, 2, 2.13% Journal of Porphyrins and Phthalocyanines 2 publications, 2.13%
Nanomaterials	Nanomaterials, 2, 2.13% Nanomaterials 2 publications, 2.13%
Chinese Chemical Letters	Chinese Chemical Letters, 2, 2.13% Chinese Chemical Letters 2 publications, 2.13%
Journal of Hazardous Materials	Journal of Hazardous Materials, 2, 2.13% Journal of Hazardous Materials 2 publications, 2.13%
Photodiagnosis and Photodynamic Therapy	Photodiagnosis and Photodynamic Therapy, 2, 2.13% Photodiagnosis and Photodynamic Therapy 2 publications, 2.13%
Journal of Controlled Release	Journal of Controlled Release, 2, 2.13% Journal of Controlled Release 2 publications, 2.13%
Advanced Materials	Advanced Materials, 2, 2.13% Advanced Materials 2 publications, 2.13%
Journal of Organic Chemistry	Journal of Organic Chemistry, 2, 2.13% Journal of Organic Chemistry 2 publications, 2.13%
Chemical Science	Chemical Science, 2, 2.13% Chemical Science 2 publications, 2.13%
Applied Physics Reviews	Applied Physics Reviews, 1, 1.06% Applied Physics Reviews 1 publication, 1.06%
Journal of Innovative Optical Health Sciences	Journal of Innovative Optical Health Sciences, 1, 1.06% Journal of Innovative Optical Health Sciences 1 publication, 1.06%
Nano LIFE	Nano LIFE, 1, 1.06% Nano LIFE 1 publication, 1.06%
Pharmaceutics	Pharmaceutics, 1, 1.06% Pharmaceutics 1 publication, 1.06%
Photochemical and Photobiological Sciences	Photochemical and Photobiological Sciences, 1, 1.06% Photochemical and Photobiological Sciences 1 publication, 1.06%
Science China Chemistry	Science China Chemistry, 1, 1.06% Science China Chemistry 1 publication, 1.06%
Acta Pharmaceutica Sinica B	Acta Pharmaceutica Sinica B, 1, 1.06% Acta Pharmaceutica Sinica B 1 publication, 1.06%
Materials Today Bio	Materials Today Bio, 1, 1.06% Materials Today Bio 1 publication, 1.06%
Materials Science and Engineering C	Materials Science and Engineering C, 1, 1.06% Materials Science and Engineering C 1 publication, 1.06%
Advanced Science	Advanced Science, 1, 1.06% Advanced Science 1 publication, 1.06%
Biomaterials	Biomaterials, 1, 1.06% Biomaterials 1 publication, 1.06%
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 1, 1.06% Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy 1 publication, 1.06%
Tetrahedron	Tetrahedron, 1, 1.06% Tetrahedron 1 publication, 1.06%
	1 2 3 4 5 6 7

Citations by publishers

	5 10 15 20 25 30
Elsevier	Elsevier, 28, 29.79% Elsevier 28 publications, 29.79%
Wiley	Wiley, 21, 22.34% Wiley 21 publications, 22.34%
American Chemical Society (ACS)	American Chemical Society (ACS), 20, 21.28% American Chemical Society (ACS) 20 publications, 21.28%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 13, 13.83% Royal Society of Chemistry (RSC) 13 publications, 13.83%
World Scientific	World Scientific, 4, 4.26% World Scientific 4 publications, 4.26%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 4, 4.26% Multidisciplinary Digital Publishing Institute (MDPI) 4 publications, 4.26%
Springer Nature	Springer Nature, 3, 3.19% Springer Nature 3 publications, 3.19%
American Institute of Physics (AIP)	American Institute of Physics (AIP), 1, 1.06% American Institute of Physics (AIP) 1 publication, 1.06%
	5 10 15 20 25 30

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Xiao W. et al. 2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy. // Biomaterials. 2018. Vol. 183. pp. 1-9.

GOST all authors (up to 50) Copy

Xiao W., Wang P., Ou C., Huang X., TANG Y., Wu M., Si W., Shao J., Huang W., Dong X. 2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy. // Biomaterials. 2018. Vol. 183. pp. 1-9.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.biomaterials.2018.08.034

UR - https://doi.org/10.1016%2Fj.biomaterials.2018.08.034

TI - 2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy.

T2 - Biomaterials

AU - Xiao, Wanyue

AU - Wang, Peng

AU - Ou, Changjin

AU - Huang, Xiaoyu

AU - TANG, YUNYUN

AU - Wu, Meiyan

AU - Si, Weili

AU - Shao, Jinjun

AU - Huang, Wei

AU - Dong, Xiaochen

PY - 2018

DA - 2018/11/01 00:00:00

PB - Elsevier

SP - 1-9

VL - 183

SN - 0142-9612

SN - 1878-5905

ER -

BibTex

Cite this

BibTex Copy

@article{2018_Xiao,

author = {Wanyue Xiao and Peng Wang and Changjin Ou and Xiaoyu Huang and YUNYUN TANG and Meiyan Wu and Weili Si and Jinjun Shao and Wei Huang and Xiaochen Dong},

title = {2-Pyridone-functionalized Aza-BODIPY photosensitizer for imaging-guided sustainable phototherapy.},

journal = {Biomaterials},

year = {2018},

volume = {183},

publisher = {Elsevier},

month = {nov},

url = {https://doi.org/10.1016%2Fj.biomaterials.2018.08.034},

pages = {1--9},

doi = {10.1016/j.biomaterials.2018.08.034}

}

Found error?

Publisher

Elsevier

Journal

Biomaterials

Quartile SCImago

Quartile WOS

Impact factor

ISSN

01429612 (Print)
18785905 (Electronic)