Open Access

Biomaterials, volume 240, pages 119850

Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy.

Liang Shuang ^{1, 2}

Sun Chunqiang

Yang Piaoping ³

Ma Ping'an ^{1, 2}

Huang Shanshan ⁴

Cheng Zi-Yong ^{1, 2}

Yu Xifei ^{5, 6}

Lin Jun ^{7, 8}

Hide authors affiliations Show authors affiliations: 8 affiliations

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China |

University of Science and Technology of China, Hefei, 230026, China. |

Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering, Harbin Engineering University, Harbin, 150001, China |

⁴

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Changchun, 130022, China. |

⁵

University of Science and Technology of China, Hefei, 230026, China |

⁶

The Polymer Composites Engineering Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China. |

⁷

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China |

⁸

UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA, HEFEI 230026, CHINA |

Publication type: Journal Article

Publication date: 2020-05-01

Elsevier

Journal: Biomaterials

Quartile SCImago

Quartile WOS

Impact factor: 14

ISSN: 01429612, 18785905

DOI: 10.1016/j.biomaterials.2020.119850

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Ceramics and Composites

Biophysics

Bioengineering

Biomaterials

Mechanics of Materials

Abstract

Recently, photodynamic therapy (PDT) has been deemed to be the most promising strategy for cancer treatment. To improve the efficacy for PDT, nanocarriers are expected to target mitochondria that are vulnerable to toxic reactive oxygen species (ROS). Moreover, overcoming tumor hypoxia is also conducive to enhance the PDT efficacy. Upconversion nanoparticles (UCNPs) can convert near infrared (NIR) light to visible light, thus stimulating photosensitizers to effectively produce cytotoxic ROS and achieving a high tissue penetration depth. In this study, a multifunctional nanocarrier UCNPs@G4/Ce6/CAT-CTPP was synthesized by a novel thiol-ene and azide-acetylene click reaction route to connect the original oleic acid ligands and dendrimers. Interestingly, the constructed and hydrophilic pockets around one single upconversion nanoparticle can simultaneously load hydrophobic photosensitizer Chlorin e6 (Ce6) and hydrophilic catalase (CTA) for catalytic enhanced PDT activated by NIR laser. Also, the mitochondrial targeting molecules (3-carboxypropyl) triphenylphosphonium bromide (CTPP) were modified outside of the dendrimers to efficiently target mitochondria. Both the catalytic degradation of hydrogen peroxide (H2O2) by catalase to overcome tumor hypoxia and mitochondrial targeting greatly enhance the efficacy of PDT. More importantly, this system provides a new paradigm for designing inorganic nanocrystal core and dendrimer shell for cargo delivery.

By date By citations

Citations by journals

	1 2 3 4 5 6
Coordination Chemistry Reviews	Coordination Chemistry Reviews, 6, 7.23% Coordination Chemistry Reviews 6 publications, 7.23%
Advanced Materials	Advanced Materials, 5, 6.02% Advanced Materials 5 publications, 6.02%
Chemical Engineering Journal	Chemical Engineering Journal, 3, 3.61% Chemical Engineering Journal 3 publications, 3.61%
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology	Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 3, 3.61% Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 3 publications, 3.61%
Biomaterials Science	Biomaterials Science, 3, 3.61% Biomaterials Science 3 publications, 3.61%
ACS Applied Bio Materials	ACS Applied Bio Materials, 2, 2.41% ACS Applied Bio Materials 2 publications, 2.41%
Frontiers in Bioengineering and Biotechnology	Frontiers in Bioengineering and Biotechnology, 2, 2.41% Frontiers in Bioengineering and Biotechnology 2 publications, 2.41%
Biosensors	Biosensors, 2, 2.41% Biosensors 2 publications, 2.41%
Bioactive Materials	Bioactive Materials, 2, 2.41% Bioactive Materials 2 publications, 2.41%
Advanced healthcare materials	Advanced healthcare materials, 2, 2.41% Advanced healthcare materials 2 publications, 2.41%
Small	Small, 2, 2.41% Small 2 publications, 2.41%
ACS Biomaterials Science and Engineering	ACS Biomaterials Science and Engineering, 2, 2.41% ACS Biomaterials Science and Engineering 2 publications, 2.41%
ACS applied materials & interfaces	ACS applied materials & interfaces, 2, 2.41% ACS applied materials & interfaces 2 publications, 2.41%
Nanoscale	Nanoscale, 2, 2.41% Nanoscale 2 publications, 2.41%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 2, 2.41% Journal of Materials Chemistry B 2 publications, 2.41%
Accounts of Chemical Research	Accounts of Chemical Research, 1, 1.2% Accounts of Chemical Research 1 publication, 1.2%
Nanomedicine	Nanomedicine, 1, 1.2% Nanomedicine 1 publication, 1.2%
Acta Chimica Sinica	Acta Chimica Sinica, 1, 1.2% Acta Chimica Sinica 1 publication, 1.2%
Biomedicines	Biomedicines, 1, 1.2% Biomedicines 1 publication, 1.2%
Nanomaterials	Nanomaterials, 1, 1.2% Nanomaterials 1 publication, 1.2%
Pharmaceutics	Pharmaceutics, 1, 1.2% Pharmaceutics 1 publication, 1.2%
Frontiers in Pharmacology	Frontiers in Pharmacology, 1, 1.2% Frontiers in Pharmacology 1 publication, 1.2%
Frontiers in Chemistry	Frontiers in Chemistry, 1, 1.2% Frontiers in Chemistry 1 publication, 1.2%
Nanoscale Research Letters	Nanoscale Research Letters, 1, 1.2% Nanoscale Research Letters 1 publication, 1.2%
Nano Convergence	Nano Convergence, 1, 1.2% Nano Convergence 1 publication, 1.2%
Science China Chemistry	Science China Chemistry, 1, 1.2% Science China Chemistry 1 publication, 1.2%
Nano Today	Nano Today, 1, 1.2% Nano Today 1 publication, 1.2%
Chinese Chemical Letters	Chinese Chemical Letters, 1, 1.2% Chinese Chemical Letters 1 publication, 1.2%
Life Sciences	Life Sciences, 1, 1.2% Life Sciences 1 publication, 1.2%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10 12 14 16 18
Elsevier	Elsevier, 18, 21.69% Elsevier 18 publications, 21.69%
Wiley	Wiley, 16, 19.28% Wiley 16 publications, 19.28%
American Chemical Society (ACS)	American Chemical Society (ACS), 12, 14.46% American Chemical Society (ACS) 12 publications, 14.46%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 8, 9.64% Royal Society of Chemistry (RSC) 8 publications, 9.64%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 6, 7.23% Multidisciplinary Digital Publishing Institute (MDPI) 6 publications, 7.23%
Frontiers Media S.A.	Frontiers Media S.A., 4, 4.82% Frontiers Media S.A. 4 publications, 4.82%
Springer Nature	Springer Nature, 4, 4.82% Springer Nature 4 publications, 4.82%
KeAi Communications Co.	KeAi Communications Co., 2, 2.41% KeAi Communications Co. 2 publications, 2.41%
Future Medicine	Future Medicine, 1, 1.2% Future Medicine 1 publication, 1.2%
Shanghai Institute of Organic Chemistry	Shanghai Institute of Organic Chemistry, 1, 1.2% Shanghai Institute of Organic Chemistry 1 publication, 1.2%
IOP Publishing	IOP Publishing, 1, 1.2% IOP Publishing 1 publication, 1.2%
Dove Medical Press	Dove Medical Press, 1, 1.2% Dove Medical Press 1 publication, 1.2%
Pleiades Publishing	Pleiades Publishing, 1, 1.2% Pleiades Publishing 1 publication, 1.2%
	2 4 6 8 10 12 14 16 18

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Liang S. et al. Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy. // Biomaterials. 2020. Vol. 240. p. 119850.

GOST all authors (up to 50) Copy

Liang S., Sun C., Yang P., Ma P., Huang S., Cheng Z., Yu X., Lin J. Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy. // Biomaterials. 2020. Vol. 240. p. 119850.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.biomaterials.2020.119850

UR - https://doi.org/10.1016%2Fj.biomaterials.2020.119850

TI - Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy.

T2 - Biomaterials

AU - Liang, Shuang

AU - Sun, Chunqiang

AU - Yang, Piaoping

AU - Ma, Ping'an

AU - Huang, Shanshan

AU - Cheng, Zi-Yong

AU - Yu, Xifei

AU - Lin, Jun

PY - 2020

DA - 2020/05/01 00:00:00

PB - Elsevier

SP - 119850

VL - 240

SN - 0142-9612

SN - 1878-5905

ER -

BibTex

Cite this

BibTex Copy

@article{2020_Liang,

author = {Shuang Liang and Chunqiang Sun and Piaoping Yang and Ping'an Ma and Shanshan Huang and Zi-Yong Cheng and Xifei Yu and Jun Lin},

title = {Core-shell structured upconversion nanocrystal-dendrimer composite as a carrier for mitochondria targeting and catalase enhanced anti-cancer photodynamic therapy.},

journal = {Biomaterials},

year = {2020},

volume = {240},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016%2Fj.biomaterials.2020.119850},

pages = {119850},

doi = {10.1016/j.biomaterials.2020.119850}

}

Found error?

Publisher

Elsevier

Journal

Biomaterials

Quartile SCImago

Quartile WOS

Impact factor

ISSN

01429612 (Print)
18785905 (Electronic)