Biosensors and Bioelectronics, volume 180, pages 113109

Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF

Guselnikova Olga 1, 2
Lim Hyun-Soo 3
Na Jongbeom 4, 5
Eguchi Miharu 6, 7
Svorcik Vaclav 9
Semyonov Oleg 10
Miliutina E 1, 2
Lyutakov Oleksiy 1, 2
3
 
Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia
4
 
Brisbane QLD 4072 Australia
5
 
Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland
7
 
Australian Institute for Bioengineering and Nanotechnology (AIBN) the University of Queensland Brisbane Qld 4072 Australia
8
 
Surface Technology Group, Korea Institute of Industrial Technology (KITECH), Incheon 21999, Republic of Korea
Publication typeJournal Article
Publication date2021-05-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor12.6
ISSN09565663, 18734235
General Medicine
Biophysics
Electrochemistry
Biotechnology
Biomedical Engineering
Abstract
Here, we present a new family of hierarchical porous hybrid materials as an innovative tool for ultrasensitive and selective sensing of enantiomeric drugs in complex biosamples via chiral surface-enhanced Raman spectroscopy (SERS). Hierarchical porous hybrid films were prepared by the combination of mesoporous plasmonic Au films and microporous homochiral metal-organic frameworks (HMOFs). The proposed hierarchical porous substrates enable extremely low limit of detection values (10 −12 M) for pseudoephedrine in undiluted blood plasma due to dual enhancement mechanisms (physical enhancement by the mesoporous Au nanostructures and chemical enhancement by HMOF), chemical recognition by HMOF, and a discriminant function for bio-samples containing large biomolecules, such as blood components. We demonstrate the effect of each component (mesoporous Au and microporous AlaZnCl (HMOF)) on the analytical performance for sensing. The growth of AlaZnCl leads to an increase in the SERS signal (by around 17 times), while the use of mesoporous Au leads to an increase in the signal (by up to 40%). In the presence of a complex biomatrix (blood serum or plasma), the hybrid hierarchical porous substrate provides control over the transport of the molecules inside the pores and prevents blood protein infiltration, provoking competition with existing plasmonic materials at the limit of detection and enantioselectivity in the presence of a multicomponent biomatrix. • Porous SERS senor discriminates chiral drug in the complex biomatrix. • Hierarchical porous sensor consists of mesoporous gold film and nanoporous chiral MOF. • Sensor distinguish two pseudoephedrine (PE) enantiomers with high enantioselectivity and sensitivity. • Sensor provide 10 −12 M LOD for PE in undiluted blood plasma. • Chiral MOF layer provide additional chemical SERS enhancement with chemical recognition and discriminant function.

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Guselnikova O. et al. Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF // Biosensors and Bioelectronics. 2021. Vol. 180. p. 113109.
GOST all authors (up to 50) Copy
Guselnikova O., Lim H., Na J., Eguchi M., Kim H., Elashnikov R., Postnikov P. S., Svorcik V., Semyonov O., Miliutina E., Lyutakov O., YAMAUCHI Y. Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF // Biosensors and Bioelectronics. 2021. Vol. 180. p. 113109.
RIS |
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TY - JOUR
DO - 10.1016/j.bios.2021.113109
UR - https://doi.org/10.1016%2Fj.bios.2021.113109
TI - Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF
T2 - Biosensors and Bioelectronics
AU - Guselnikova, Olga
AU - Lim, Hyun-Soo
AU - Na, Jongbeom
AU - Eguchi, Miharu
AU - Kim, Hyun-Jong
AU - Elashnikov, Roman
AU - Postnikov, Pavel S.
AU - Svorcik, Vaclav
AU - Semyonov, Oleg
AU - Miliutina, E
AU - Lyutakov, Oleksiy
AU - YAMAUCHI, Yusuke
PY - 2021
DA - 2021/05/01 00:00:00
PB - Elsevier
SP - 113109
VL - 180
SN - 0956-5663
SN - 1873-4235
ER -
BibTex
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BibTex Copy
@article{2021_Guselnikova
author = {Olga Guselnikova and Hyun-Soo Lim and Jongbeom Na and Miharu Eguchi and Hyun-Jong Kim and Roman Elashnikov and Pavel S. Postnikov and Vaclav Svorcik and Oleg Semyonov and E Miliutina and Oleksiy Lyutakov and Yusuke YAMAUCHI},
title = {Enantioselective SERS sensing of pseudoephedrine in blood plasma biomatrix by hierarchical mesoporous Au films coated with a homochiral MOF},
journal = {Biosensors and Bioelectronics},
year = {2021},
volume = {180},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016%2Fj.bios.2021.113109},
pages = {113109},
doi = {10.1016/j.bios.2021.113109}
}
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