The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.
Elena Matyugina
1
,
Larisa Chernousova
3
,
Sofia Andreevskaya
3
,
Tatiana Smirnova
3
,
A. O. Chizhov
4
,
И. Л. Карпенко
2
,
С. Н. Кочетков
2
,
Ludmila Alexandrova
2
Publication type: Journal Article
Publication date: 2012-11-01
scimago Q2
wos Q1
SJR: 0.608
CiteScore: 6.7
Impact factor: 3.0
ISSN: 09680896, 14643391
PubMed ID:
23062712
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A series of new carbocyclic uracil derivatives were synthesized and evaluated as potential antituberculosis agents. Racemic 1-[4'-hydroxy-2'-cyclopenten-1'-yl]-5-tetradecynyluracil completely inhibited the growth of Mycobacterium tuberculosis H37Rv in vitro at a concentration of 10 μg/ml. Individual (+) and (-) isomers of the above uracil derivative were isolated and showed the same level of activity against two strains of Mycobacterium tuberculosis: laboratory sensitive (H37Rv) and clinical resistant to five top antituberculosis drugs (MS-115).
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48
Total citations:
48
Citations from 2024:
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(4%)
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GOST
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Matyugina E. et al. The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives. // Bioorganic and Medicinal Chemistry. 2012. Vol. 20. No. 22. pp. 6680-6686.
GOST all authors (up to 50)
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Matyugina E., Khandazhinskaya A., Chernousova L., Andreevskaya S., Smirnova T., Chizhov A. O., Карпенко И. Л., Кочетков С. Н., Alexandrova L. The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives. // Bioorganic and Medicinal Chemistry. 2012. Vol. 20. No. 22. pp. 6680-6686.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmc.2012.09.019
UR - https://doi.org/10.1016/j.bmc.2012.09.019
TI - The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.
T2 - Bioorganic and Medicinal Chemistry
AU - Matyugina, Elena
AU - Khandazhinskaya, Anastasia
AU - Chernousova, Larisa
AU - Andreevskaya, Sofia
AU - Smirnova, Tatiana
AU - Chizhov, A. O.
AU - Карпенко, И. Л.
AU - Кочетков, С. Н.
AU - Alexandrova, Ludmila
PY - 2012
DA - 2012/11/01
PB - Elsevier
SP - 6680-6686
IS - 22
VL - 20
PMID - 23062712
SN - 0968-0896
SN - 1464-3391
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Matyugina,
author = {Elena Matyugina and Anastasia Khandazhinskaya and Larisa Chernousova and Sofia Andreevskaya and Tatiana Smirnova and A. O. Chizhov and И. Л. Карпенко and С. Н. Кочетков and Ludmila Alexandrova},
title = {The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.},
journal = {Bioorganic and Medicinal Chemistry},
year = {2012},
volume = {20},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.bmc.2012.09.019},
number = {22},
pages = {6680--6686},
doi = {10.1016/j.bmc.2012.09.019}
}
Cite this
MLA
Copy
Matyugina, Elena, et al. “The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives..” Bioorganic and Medicinal Chemistry, vol. 20, no. 22, Nov. 2012, pp. 6680-6686. https://doi.org/10.1016/j.bmc.2012.09.019.