Bioorganic and Medicinal Chemistry Letters, volume 25, issue 2, pages 404-409
Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors
Ivanenkov Yan
1, 2
,
Vasilevski Sergei V
1
,
Beloglazkina Elena K.
1, 3
,
Kukushkin Maksim E
1
,
Machulkin Alexey E.
1, 4
,
Veselov Mark S.
5
,
Chufarova Nina V
2, 6
,
Chernyaginab Elizaveta S
5
,
Vanzcool Anton S
7
,
Zyk Nikolay V.
1
,
Skvortsov Dmitry
1
,
Khutornenko Anastasia A.
8
,
Rusanov Alexander L.
9
,
Tonevitsky Alexander
10, 11
,
Dontsova Olga A.
1, 8
,
Majouga Alexander G.
1, 12
1
7
ChemDiv, Inc., 6605 Nancy Ridge Drive, San Diego, CA 92121, USA.
|
10
SRC Bioclinicum, Ugreshskaya str 2/85, Moscow 115088, Russia
|
11
Publication type: Journal Article
Publication date: 2015-01-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Regioselective synthesis, biological evaluation and 3D-molecular modeling for a series of novel diastereomeric 2-thioxo-5H-dispiro[imidazolidine-4,3-pyrrolidine-2,3-indole]-2,5(1H)-diones are described. The studied compounds have been tentatively identified as potent small molecule MDM2/p53 PPI inhibitors and can therefore be reasonably regarded as promising anticancer therapeutics.
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1
2
3
4
5
6
7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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GOST
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Ivanenkov Y. et al. Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 2. pp. 404-409.
GOST all authors (up to 50)
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Ivanenkov Y., Vasilevski S. V., Beloglazkina E. K., Kukushkin M. E., Machulkin A. E., Veselov M. S., Chufarova N. V., Chernyaginab E. S., Vanzcool A. S., Zyk N. V., Skvortsov D., Khutornenko A. A., Rusanov A. L., Tonevitsky A., Dontsova O. A., Majouga A. G. Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 2. pp. 404-409.
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TY - JOUR
DO - 10.1016/j.bmcl.2014.09.070
UR - https://doi.org/10.1016%2Fj.bmcl.2014.09.070
TI - Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Ivanenkov, Yan
AU - Vasilevski, Sergei V
AU - Kukushkin, Maksim E
AU - Machulkin, Alexey E.
AU - Veselov, Mark S.
AU - Chufarova, Nina V
AU - Chernyaginab, Elizaveta S
AU - Vanzcool, Anton S
AU - Zyk, Nikolay V.
AU - Khutornenko, Anastasia A.
AU - Rusanov, Alexander L.
AU - Dontsova, Olga A.
AU - Beloglazkina, Elena K.
AU - Skvortsov, Dmitry
AU - Tonevitsky, Alexander
AU - Majouga, Alexander G.
PY - 2015
DA - 2015/01/01 00:00:00
PB - Elsevier
SP - 404-409
IS - 2
VL - 25
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2015_Ivanenkov,
author = {Yan Ivanenkov and Sergei V Vasilevski and Maksim E Kukushkin and Alexey E. Machulkin and Mark S. Veselov and Nina V Chufarova and Elizaveta S Chernyaginab and Anton S Vanzcool and Nikolay V. Zyk and Anastasia A. Khutornenko and Alexander L. Rusanov and Olga A. Dontsova and Elena K. Beloglazkina and Dmitry Skvortsov and Alexander Tonevitsky and Alexander G. Majouga},
title = {Design, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2015},
volume = {25},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.bmcl.2014.09.070},
number = {2},
pages = {404--409},
doi = {10.1016/j.bmcl.2014.09.070}
}
Cite this
MLA
Copy
Ivanenkov, Yan, et al. āDesign, synthesis and biological evaluation of novel potent MDM2/p53 small-molecule inhibitors.ā Bioorganic and Medicinal Chemistry Letters, vol. 25, no. 2, Jan. 2015, pp. 404-409. https://doi.org/10.1016%2Fj.bmcl.2014.09.070.