Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphile.
Pavel A Puchkov
1
,
Elena Shmendel
1
,
Anastasya S Luneva
1
,
Nina G. Morozova
1
,
М. А. Зенкова
2
,
Publication type: Journal Article
Publication date: 2016-12-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
27836397
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A novel redox-sensitive polycationic amphiphile (2S3) with disulphide linkers for nucleic acid delivery was developed. Cationic liposomes formed by 2S3 and the helper lipid DOPE demonstrated effective DNA delivery into HEK293 cells with a maximal transfection activity that is superior than both nonredox-sensitive cationic liposomes and Lipofectamine® 2000 at an N/P ratio of 6/1. Redox-sensitivity was tested by experiments with extracellular glutathione which shown the ability of disulphide linker degradation. Our results suggest that polycationic amphiphile 2S3 is a promising candidate for nucleic acid delivery.
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Total citations:
18
Citations from 2024:
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GOST
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Puchkov P. A. et al. Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphile. // Bioorganic and Medicinal Chemistry Letters. 2016. Vol. 26. No. 24. pp. 5911-5915.
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Puchkov P. A., Shmendel E., Luneva A. S., Morozova N. G., Зенкова М. А., Maslov M. Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphile. // Bioorganic and Medicinal Chemistry Letters. 2016. Vol. 26. No. 24. pp. 5911-5915.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2016.11.005
UR - https://linkinghub.elsevier.com/retrieve/pii/S0960894X16311453
TI - Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphile.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Puchkov, Pavel A
AU - Shmendel, Elena
AU - Luneva, Anastasya S
AU - Morozova, Nina G.
AU - Зенкова, М. А.
AU - Maslov, Michael
PY - 2016
DA - 2016/12/01
PB - Elsevier
SP - 5911-5915
IS - 24
VL - 26
PMID - 27836397
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2016_Puchkov,
author = {Pavel A Puchkov and Elena Shmendel and Anastasya S Luneva and Nina G. Morozova and М. А. Зенкова and Michael Maslov},
title = {Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphile.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2016},
volume = {26},
publisher = {Elsevier},
month = {dec},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0960894X16311453},
number = {24},
pages = {5911--5915},
doi = {10.1016/j.bmcl.2016.11.005}
}
Cite this
MLA
Copy
Puchkov, Pavel A., et al. “Design, synthesis and transfection efficiency of a novel redox-sensitive polycationic amphiphile..” Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 24, Dec. 2016, pp. 5911-5915. https://linkinghub.elsevier.com/retrieve/pii/S0960894X16311453.
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