Bioorganic and Medicinal Chemistry Letters, volume 28, issue 3, pages 382-387
Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates
Ivanenkov Yan
2
,
Sergeeva Olga
2, 3
,
Saltykova Irina V
1
,
Kireev I.
4
,
Alieva Irina B.
4
,
Deyneka Ekaterina V.
5
,
Sofronova Alina A.
6
,
Aladinskaia Anastasiia V
5
,
Trofimenko Alexandre V
5
,
Yamidanov Renat S.
7
,
Kovalev Sergey
1
,
Kotelianski Victor E
8
,
Zatsepin Timofei S.
2, 3
,
Publication type: Journal Article
Publication date: 2018-02-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Asialoglycoprotein receptor (ASGP-R) is a promising biological target for drug delivery into hepatoma cells. Nevertheless, there are only few examples of small-molecule conjugates of ASGP-R selective ligand equipped by a therapeutic agent for the treatment of hepatocellular carcinoma (HCC). In the present work, we describe a convenient and versatile synthetic approach to novel mono- and multivalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose and anticancer drug - paclitaxel (PTX). Several molecules have demonstrated high affinity towards ASGP-R and good stability under physiological conditions, significant in vitro anticancer activity comparable to PTX, as well as good internalization via ASGP-R-mediated endocytosis. Therefore, the conjugates with the highest potency can be regarded as a promising therapeutic option against HCC.
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Citations by publishers
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1
2
3
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American Chemical Society (ACS)
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3 publications, 17.65%
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2 publications, 11.76%
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2 publications, 11.76%
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2 publications, 11.76%
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1 publication, 5.88%
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SAGE
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1 publication, 5.88%
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1 publication, 5.88%
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Wiley
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1 publication, 5.88%
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Multidisciplinary Digital Publishing Institute (MDPI)
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1 publication, 5.88%
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Moscow University Press
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Moscow University Press
1 publication, 5.88%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Maklakova S. et al. Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates // Bioorganic and Medicinal Chemistry Letters. 2018. Vol. 28. No. 3. pp. 382-387.
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Maklakova S., Ivanenkov Y., Petrov S. B., Sergeeva O., Yamansarov E. Yu., Saltykova I. V., Kireev I., Alieva I. B., Deyneka E. V., Sofronova A. A., Aladinskaia A. V., Trofimenko A. V., Yamidanov R. S., Kovalev S., Kotelianski V. E., Zatsepin T. S., Beloglazkina E. K., Majouga A. G. Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates // Bioorganic and Medicinal Chemistry Letters. 2018. Vol. 28. No. 3. pp. 382-387.
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TY - JOUR
DO - 10.1016/j.bmcl.2017.12.032
UR - https://doi.org/10.1016%2Fj.bmcl.2017.12.032
TI - Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Petrov, Stanislav B.
AU - Maklakova, Svetlana
AU - Ivanenkov, Yan
AU - Sergeeva, Olga
AU - Yamansarov, Emil Yu
AU - Saltykova, Irina V
AU - Kireev, I.
AU - Alieva, Irina B.
AU - Deyneka, Ekaterina V.
AU - Sofronova, Alina A.
AU - Aladinskaia, Anastasiia V
AU - Trofimenko, Alexandre V
AU - Yamidanov, Renat S.
AU - Kovalev, Sergey
AU - Kotelianski, Victor E
AU - Zatsepin, Timofei S.
AU - Beloglazkina, Elena K.
AU - Majouga, Alexander G.
PY - 2018
DA - 2018/02/01 00:00:00
PB - Elsevier
SP - 382-387
IS - 3
VL - 28
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2018_Maklakova,
author = {Stanislav B. Petrov and Svetlana Maklakova and Yan Ivanenkov and Olga Sergeeva and Emil Yu Yamansarov and Irina V Saltykova and I. Kireev and Irina B. Alieva and Ekaterina V. Deyneka and Alina A. Sofronova and Anastasiia V Aladinskaia and Alexandre V Trofimenko and Renat S. Yamidanov and Sergey Kovalev and Victor E Kotelianski and Timofei S. Zatsepin and Elena K. Beloglazkina and Alexander G. Majouga},
title = {Synthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2018},
volume = {28},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.bmcl.2017.12.032},
number = {3},
pages = {382--387},
doi = {10.1016/j.bmcl.2017.12.032}
}
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MLA
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Maklakova, Svetlana, et al. āSynthesis and biological evaluation of novel mono- and bivalent ASGP-R-targeted drug-conjugates.ā Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 3, Feb. 2018, pp. 382-387. https://doi.org/10.1016%2Fj.bmcl.2017.12.032.