Bioorganic and Medicinal Chemistry Letters, volume 30, issue 3, pages 126894
Design and synthesis of a novel BODIPY-labeled PSMA inhibitor
Son Sang Hoo
1
,
Kwon Hongmok
1
,
Ahn Hye Kyung
2
,
Nam Hwanhee
3, 4
,
Kim Kyul
1
,
Nam Sang Yong
1
,
Choi Doyoung
1
,
Ha Hyunsoo
1
,
Minn Il
3
,
Byun Youngjoo
5
1
College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong, 30019, Republic of Korea.
|
5
College of Pharmacy, Korea University, 2511 Sejong-ro, Sejong 30019, Republic of Korea
|
Publication type: Journal Article
Publication date: 2020-02-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Prostate-specific membrane antigen (PSMA) is a zinc-bound metalloprotease which is highly expressed in metastatic prostate cancer. It has been considered an excellent target protein for prostate cancer imaging and targeted therapy because it is a membrane protein and its active site is located in the extracellular region. We successfully synthesized and evaluated a novel PSMA ligand conjugated with BODIPY650/665. Compound 1 showed strong PSMA-inhibitory activity and selective uptake into PSMA-expressing tumors. Compound 1 has the potential to be utilized as a near infrared (NIR) optical imaging probe targeting PSMA-expressing cancers.
Citations by journals
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1
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Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry
1 publication, 16.67%
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European Journal of Medicinal Chemistry
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European Journal of Medicinal Chemistry
1 publication, 16.67%
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Current Medicinal Chemistry
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Current Medicinal Chemistry
1 publication, 16.67%
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Frontiers in Oncology
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Frontiers in Oncology
1 publication, 16.67%
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Bioorganic Chemistry
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Bioorganic Chemistry
1 publication, 16.67%
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ChemMedChem
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ChemMedChem
1 publication, 16.67%
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1
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Citations by publishers
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1
2
|
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Elsevier
|
Elsevier
2 publications, 33.33%
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|
American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 16.67%
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Bentham Science
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Bentham Science
1 publication, 16.67%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 16.67%
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Wiley
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Wiley
1 publication, 16.67%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Son S. H. et al. Design and synthesis of a novel BODIPY-labeled PSMA inhibitor // Bioorganic and Medicinal Chemistry Letters. 2020. Vol. 30. No. 3. p. 126894.
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Son S. H., Kwon H., Ahn H. K., Nam H., Kim K., Nam S. Y., Choi D., Ha H., Minn I., Byun Y. Design and synthesis of a novel BODIPY-labeled PSMA inhibitor // Bioorganic and Medicinal Chemistry Letters. 2020. Vol. 30. No. 3. p. 126894.
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TY - JOUR
DO - 10.1016/j.bmcl.2019.126894
UR - https://doi.org/10.1016%2Fj.bmcl.2019.126894
TI - Design and synthesis of a novel BODIPY-labeled PSMA inhibitor
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Son, Sang Hoo
AU - Kwon, Hongmok
AU - Ahn, Hye Kyung
AU - Nam, Hwanhee
AU - Kim, Kyul
AU - Nam, Sang Yong
AU - Choi, Doyoung
AU - Ha, Hyunsoo
AU - Minn, Il
AU - Byun, Youngjoo
PY - 2020
DA - 2020/02/01 00:00:00
PB - Elsevier
SP - 126894
IS - 3
VL - 30
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2020_Son,
author = {Sang Hoo Son and Hongmok Kwon and Hye Kyung Ahn and Hwanhee Nam and Kyul Kim and Sang Yong Nam and Doyoung Choi and Hyunsoo Ha and Il Minn and Youngjoo Byun},
title = {Design and synthesis of a novel BODIPY-labeled PSMA inhibitor},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2020},
volume = {30},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016%2Fj.bmcl.2019.126894},
number = {3},
pages = {126894},
doi = {10.1016/j.bmcl.2019.126894}
}
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MLA
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Son, Sang Hoo, et al. “Design and synthesis of a novel BODIPY-labeled PSMA inhibitor.” Bioorganic and Medicinal Chemistry Letters, vol. 30, no. 3, Feb. 2020, p. 126894. https://doi.org/10.1016%2Fj.bmcl.2019.126894.