Brain Research, volume 1661, pages 1-14
Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs
Publication type: Journal Article
Publication date: 2017-04-01
Journal:
Brain Research
Quartile SCImago
Q2
Quartile WOS
Q3
Impact factor: 2.9
ISSN: 00068993, 18726240
Molecular Biology
Developmental Biology
General Neuroscience
Neurology (clinical)
Abstract
Changes in rhythmic activity can serve as early biomarkers of pathological alterations, but it remains unclear how different types of rhythmic activity are altered during neurodegenerative processes. Glutamatergic neurotoxicity, evoked by kainic acid (KA), causes hyperexcitation and acute seizures that result in delayed brain damage. We employed wide frequency range (0.1-300Hz) local field potential recordings in guinea pigs to study the oscillatory activity of the hippocampus, entorhinal cortex, medial septum, and amygdala in healthy animals for three months after KA introduction. To clarify whether the activation of endocannabinoid (eCB) system can influence toxic KA action, AM404, an eCB reuptake inhibitor, and URB597, an inhibitor of fatty acid amide hydrolase, were applied. The cannabinoid CB1 receptor antagonist AM251 was also tested. Coadministration of AM404 or URB597 with KA reduced acute behavioral seizures, but electrographic seizures were still registered. During the three months following KA injection, various trends in the oscillatory activities were observed, including an increase in activity power at all frequency bands in the hippocampus and a progressive long-term decrease in the medial septum. In the KA- and KA/AM251-treated animals, disturbances of the oscillatory activities were accompanied by cell loss in the dorsal hippocampus and mossy fiber sprouting in the dentate gyrus. Injections of AM404 or URB597 softened alterations in electrical activity of the brain and prevented hippocampal neuron loss and synaptic reorganization. Our results demonstrate the protective potential of the eCB system during excitotoxic influences.
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Shubina L., Aliev R., Kitchigina V. Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs // Brain Research. 2017. Vol. 1661. pp. 1-14.
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Shubina L., Aliev R., Kitchigina V. Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs // Brain Research. 2017. Vol. 1661. pp. 1-14.
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TY - JOUR
DO - 10.1016/j.brainres.2017.02.003
UR - https://doi.org/10.1016%2Fj.brainres.2017.02.003
TI - Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs
T2 - Brain Research
AU - Shubina, Liubov
AU - Kitchigina, V.F.
AU - Aliev, Rubin
PY - 2017
DA - 2017/04/01 00:00:00
PB - Elsevier
SP - 1-14
VL - 1661
SN - 0006-8993
SN - 1872-6240
ER -
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@article{2017_Shubina,
author = {Liubov Shubina and V.F. Kitchigina and Rubin Aliev},
title = {Endocannabinoid-dependent protection against kainic acid-induced long-term alteration of brain oscillations in guinea pigs},
journal = {Brain Research},
year = {2017},
volume = {1661},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016%2Fj.brainres.2017.02.003},
pages = {1--14},
doi = {10.1016/j.brainres.2017.02.003}
}
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