Cancer Letters, volume 450, pages 98-109

A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA

He Jia ¹

Zuo Qiaozhu ¹

Bo Hu 胡波 ²

Jin Haojie ¹

Wang Cun Yu ¹

Cheng Zhuoan ³

Deng Xuan ⁴

Yang Chen ⁴

Ruan Haoyu ⁴

Yu Chengtao ³

Zhao Fangyu ¹

Yao Ming ¹

Fang Jing-Yuan ¹

Gu Jianren ¹

Zhou Jian ²

Jia Fan ²

Qin Wen-Xin ¹

Yang Xinrong ²

Wang Hui ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200032, China |

Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai, 200032, China. |

School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China |

⁴

Shanghai Medical College of Fudan University,Shanghai 200032,China) |

Publication type: Journal Article

Publication date: 2019-05-01

Elsevier

Journal: Cancer Letters

Quartile SCImago

Quartile WOS

Impact factor: 9.7

ISSN: 03043835, 18727980

DOI: 10.1016/j.canlet.2019.02.033

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Cancer Research

Oncology

Abstract

Long noncoding RNAs (lncRNAs) are implicated as novel drivers in hepatocellular carcinoma (HCC), but the underlying mechanisms of this relationship with hepatocarcinogenesis are unknown. We report a novel, liver-specific lncRNA LINC01093 that shows significant downregulation in HCC tissues. LINC01093 expression is inversely correlated with cancer embolus and HCC TNM stage and as a prognostic predictor for HCC patients. LINC01093 overexpression significantly suppresses HCC cell proliferation and metastasis in vitro and in vivo. Conversely, its knockdown promotes HCC progression. Mechanistic analyses indicate that LINC01093 directly binds insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), interfering with interaction between IGF2BP1 and glioma-associated oncogene homolog 1 (GLI1) mRNA. The result is degradation of GLI1 mRNA, further affecting expression of GLI1 downstream molecules involved in HCC progression. The liver-enriched lncRNA LINC01093 is a promising prognostic indicator for HCC patients, and the newly identified LINC01093-IGF2BP1-GLI1 axis shows potential for therapeutic targets in HCC.

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Citations by journals

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BioMed Research International	BioMed Research International, 2, 2.27% BioMed Research International 2 publications, 2.27%
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Molecular Medicine Reports	Molecular Medicine Reports, 1, 1.14% Molecular Medicine Reports 1 publication, 1.14%
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Citations by publishers

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Springer Nature	Springer Nature, 23, 26.14% Springer Nature 23 publications, 26.14%
Elsevier	Elsevier, 21, 23.86% Elsevier 21 publications, 23.86%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 7, 7.95% Multidisciplinary Digital Publishing Institute (MDPI) 7 publications, 7.95%
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Bentham Science	Bentham Science, 1, 1.14% Bentham Science 1 publication, 1.14%
PeerJ	PeerJ, 1, 1.14% PeerJ 1 publication, 1.14%
Tech Science Press	Tech Science Press, 1, 1.14% Tech Science Press 1 publication, 1.14%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 1.14% Public Library of Science (PLoS) 1 publication, 1.14%
Taylor & Francis	Taylor & Francis, 1, 1.14% Taylor & Francis 1 publication, 1.14%
American Association for Cancer Research (AACR)	American Association for Cancer Research (AACR), 1, 1.14% American Association for Cancer Research (AACR) 1 publication, 1.14%
SAGE	SAGE, 1, 1.14% SAGE 1 publication, 1.14%
	5 10 15 20 25

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GOST Copy

He J. et al. A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA // Cancer Letters. 2019. Vol. 450. pp. 98-109.

GOST all authors (up to 50) Copy

He J., Zuo Q., Bo Hu 胡., Jin H., Wang C. Yu., Cheng Z., Deng X., Yang C., Ruan H., Yu C., Zhao F., Yao M., Fang J., Gu J., Zhou J., Jia F., Qin W., Yang X., Wang H. A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA // Cancer Letters. 2019. Vol. 450. pp. 98-109.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.canlet.2019.02.033

UR - https://doi.org/10.1016%2Fj.canlet.2019.02.033

TI - A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA

T2 - Cancer Letters

AU - He, Jia

AU - Zuo, Qiaozhu

AU - Bo Hu, 胡波

AU - Jin, Haojie

AU - Wang, Cun Yu

AU - Cheng, Zhuoan

AU - Deng, Xuan

AU - Yang, Chen

AU - Ruan, Haoyu

AU - Yu, Chengtao

AU - Zhao, Fangyu

AU - Yao, Ming

AU - Fang, Jing-Yuan

AU - Gu, Jianren

AU - Zhou, Jian

AU - Jia, Fan

AU - Qin, Wen-Xin

AU - Yang, Xinrong

AU - Wang, Hui

PY - 2019

DA - 2019/05/01 00:00:00

PB - Elsevier

SP - 98-109

VL - 450

SN - 0304-3835

SN - 1872-7980

ER -

BibTex

Cite this

BibTex Copy

@article{2019_He,

author = {Jia He and Qiaozhu Zuo and 胡波 Bo Hu and Haojie Jin and Cun Yu Wang and Zhuoan Cheng and Xuan Deng and Chen Yang and Haoyu Ruan and Chengtao Yu and Fangyu Zhao and Ming Yao and Jing-Yuan Fang and Jianren Gu and Jian Zhou and Fan Jia and Wen-Xin Qin and Xinrong Yang and Hui Wang},

title = {A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA},

journal = {Cancer Letters},

year = {2019},

volume = {450},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016%2Fj.canlet.2019.02.033},

pages = {98--109},

doi = {10.1016/j.canlet.2019.02.033}

}

Found error?

Publisher

Elsevier

Journal

Cancer Letters

Quartile SCImago

Quartile WOS

Impact factor

9.7

ISSN

03043835 (Print)
18727980 (Electronic)