Carbohydrate Polymers, volume 303, pages 120472
Single-molecule AFM study of hyaluronic acid softening in electrolyte solutions
4
Institut de Sciences des Matériaux de Mulhouse − IS2M, CNRS UMR7361, 15 Jean Starcky, Mulhouse 68057, France
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Publication type: Journal Article
Publication date: 2023-03-01
Journal:
Carbohydrate Polymers
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 11.2
ISSN: 01448617, 18791344
Materials Chemistry
Organic Chemistry
Polymers and Plastics
Abstract
Investigation of hyaluronic acid (HA) morphology and mechanical properties at a single-molecule level is important for the development of HA based biomaterials. We have developed the atomic force microscopy (AFM) based approach for quantitative characterization of conformation of HA molecules. HA molecules adsorbed on a modified graphitic surface form oriented linear segments. Conformation of HA molecules can be considered as two-dimensional quasi-projection of a three-dimensional conformation locally straightened by a substrate. The persistence length and Young's modulus of biomolecules estimated using wormlike chain model decrease from 15.7 to 9.9 nm, and from ∼21 to ∼13 GPa, respectively, when KCl concentration increases from 0 to 100 mM. The dependence of the persistence length on ionic strength supports the Odijk-Skolnick-Fixman model of polyelectrolyte stiffening in electrolyte solution. The obtained results represent a new insight into the conformation and mechanical characteristics of HA molecules and complement the characterization of this biopolymer by bulk methods.
Citations by journals
1
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International Journal of Biological Macromolecules
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International Journal of Biological Macromolecules
1 publication, 20%
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MRS Communications
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MRS Communications
1 publication, 20%
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Carbohydrate Polymers
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Carbohydrate Polymers
1 publication, 20%
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Langmuir
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Langmuir
1 publication, 20%
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1
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Citations by publishers
1
2
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Elsevier
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Elsevier
2 publications, 40%
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Cambridge University Press
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Cambridge University Press
1 publication, 20%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 20%
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1
2
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Dubrovin E. V. et al. Single-molecule AFM study of hyaluronic acid softening in electrolyte solutions // Carbohydrate Polymers. 2023. Vol. 303. p. 120472.
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Dubrovin E. V., Barinov N. A., Ivanov D. A., Klinov D. V. Single-molecule AFM study of hyaluronic acid softening in electrolyte solutions // Carbohydrate Polymers. 2023. Vol. 303. p. 120472.
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TY - JOUR
DO - 10.1016/j.carbpol.2022.120472
UR - https://doi.org/10.1016%2Fj.carbpol.2022.120472
TI - Single-molecule AFM study of hyaluronic acid softening in electrolyte solutions
T2 - Carbohydrate Polymers
AU - Dubrovin, Evgeniy V
AU - Barinov, Nikolay A
AU - Ivanov, Dmitry A.
AU - Klinov, Dmitry V.
PY - 2023
DA - 2023/03/01 00:00:00
PB - Elsevier
SP - 120472
VL - 303
SN - 0144-8617
SN - 1879-1344
ER -
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@article{2023_Dubrovin
author = {Evgeniy V Dubrovin and Nikolay A Barinov and Dmitry A. Ivanov and Dmitry V. Klinov},
title = {Single-molecule AFM study of hyaluronic acid softening in electrolyte solutions},
journal = {Carbohydrate Polymers},
year = {2023},
volume = {303},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016%2Fj.carbpol.2022.120472},
pages = {120472},
doi = {10.1016/j.carbpol.2022.120472}
}
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