Clinica Chimica Acta, volume 495, pages 331-337

Liquid biopsy: Circulating exosomal long noncoding RNAs in cancer

Jiang Nan 1, 2
Pan Jinchang 1, 2
Fang Shuai 1, 2
Zhou Chengwei 1, 3
]han Ying 4
Chen Jun 4
Meng Xiao-Dan 1, 2
Jin Xiaofeng 1, 2
GONG ZHAOHUI 5
1
 
Department of Biochemistry and Molecular Biology, Medical School of Ningbo University, Ningbo 315211, China
2
 
Zhejiang Province Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China.
3
 
Department of Thoracic Surgery, The Affiliated Hospital of Medical School of Ningbo University, Ningbo 315020, China.
4
 
Department of Radiation Oncology, The Affiliated Yinzhou Renmin Hospital of Medical School of Ningbo University, Ningbo 315040, China
5
 
Zhejiang Province Key Laboratory of Pathophysiology, Ningbo University School of Medicine, Ningbo 315211, China
Publication typeJournal Article
Publication date2019-08-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5
ISSN00098981, 18733492
Biochemistry
General Medicine
Clinical Biochemistry
Biochemistry (medical)
Abstract
Despite many advances in diagnostics and multimodal treatment (surgery, radiotherapy, chemotherapy), cancer still remains one of the most important public health challenges worldwide because of the associated morbidity and mortality. Liquid biopsy has been developed to detect cancer at an early stage based on minimally invasive and serial body fluid tests with the advantage of following tumor evolution in real time. Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating cell-free noncoding RNAs (cfRNAs) and circulating exosomes represent the major components of liquid biopsy analysis. Liquid biopsy already has been implemented in cancer management, and most studies thus far are mainly focused on CTCs and ctDNA. In fact, the circulating long noncoding RNAs (lncRNAs) in exosomes have been discovered and confirmed to be closely related to tumorigenesis, metastasis and therapy. Thus this review is mainly focused on the clinical potential of circulating exosomal lncRNAs as a source of liquid biopsy biomarkers in cancer diagnosis, prognosis, and response to treatment, offering novel insights into the precision medicine of oncology.

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GOST Copy
Jiang N. et al. Liquid biopsy: Circulating exosomal long noncoding RNAs in cancer // Clinica Chimica Acta. 2019. Vol. 495. pp. 331-337.
GOST all authors (up to 50) Copy
Jiang N., Pan J., Fang S., Zhou C., ]han Y., Chen J., Meng X., Jin X., GONG Z. Liquid biopsy: Circulating exosomal long noncoding RNAs in cancer // Clinica Chimica Acta. 2019. Vol. 495. pp. 331-337.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.cca.2019.04.082
UR - https://doi.org/10.1016%2Fj.cca.2019.04.082
TI - Liquid biopsy: Circulating exosomal long noncoding RNAs in cancer
T2 - Clinica Chimica Acta
AU - Jiang, Nan
AU - Pan, Jinchang
AU - Fang, Shuai
AU - Zhou, Chengwei
AU - ]han, Ying
AU - Chen, Jun
AU - Meng, Xiao-Dan
AU - Jin, Xiaofeng
AU - GONG, ZHAOHUI
PY - 2019
DA - 2019/08/01 00:00:00
PB - Elsevier
SP - 331-337
VL - 495
SN - 0009-8981
SN - 1873-3492
ER -
BibTex
Cite this
BibTex Copy
@article{2019_Jiang
author = {Nan Jiang and Jinchang Pan and Shuai Fang and Chengwei Zhou and Ying ]han and Jun Chen and Xiao-Dan Meng and Xiaofeng Jin and ZHAOHUI GONG},
title = {Liquid biopsy: Circulating exosomal long noncoding RNAs in cancer},
journal = {Clinica Chimica Acta},
year = {2019},
volume = {495},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016%2Fj.cca.2019.04.082},
pages = {331--337},
doi = {10.1016/j.cca.2019.04.082}
}
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